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Peptide H reduces Il-6 expression in human breast cancer MDA-MB-231 cells

인간유방암 MDA-MB-231세포에서 peptide H에 의한 TNFα 발현 억제

  • Sung, Dae Il (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University) ;
  • Park, Jameon (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University) ;
  • Kang, Choong Kyung (Department of Nanobiotronics, Bioconvergence Lab, Hoseo University) ;
  • Kim, Han Bok (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
  • 성대일 (호서대학교 생명공학과 기초과학연구소) ;
  • 박잠언 (호서대학교 생명공학과 기초과학연구소) ;
  • 강충경 (호서대학교 나노바이오트로닉스학과 바이오융합연구소) ;
  • 김한복 (호서대학교 생명공학과 기초과학연구소)
  • Received : 2015.07.28
  • Accepted : 2015.09.12
  • Published : 2015.09.30

Abstract

Chungkookjang (fermented soybeans) contains diverse peptides. Human breast cancer MDA-MB-231 cells were treated with peptide H derived from Chungkookjang, and $TNF{\alpha}$ expression in the cells was conspicuously repressed, suggesting peptide H's regulation of IL6 since IL6 is induced by $TNF{\alpha}$. The structure of peptide H was different from those of glucocorticoid and dexamethasone, suggesting different mechanisms of $TNF{\alpha}$ expression suppression. Peptide H which reduces $TNF{\alpha}$ expression can be developed as drugs for cancer, rheumatoid arthritis and Crohn's disease, after more investigation.

청국장은 다양한 peptide류를 포함한다. 청국장 유래의 peptide H를 인간유방암 MDA-MB-231 세포에 처리했을 때, $TNF{\alpha}$ 발현은 뚜렷하게 억제되었다. $TNF{\alpha}$에 의해 유도되는 IL6 발현 역시, peptide H에 의해 감소될 수 있음을 시사해 준다. Peptide H구조는 glucocorticoid, dexamethasone과 전혀 유사하지 않아 그들과 다른 기작으로 $TNF{\alpha}$ 발현억제에 작용할 것을 시사해 준다. Peptide H는 $TNF{\alpha}$ 발현 억제 효과가 있으므로 보다 깊이 있는 연구를 바탕으로, 류마티스 관절염, 크론병 등의 치료제로 개발될 수 있기를 기대해 본다.

Keywords

References

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