Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
권호 표지
DOI QR코드

DOI QR Code

Association of Metabolic Syndrome and Biochemical Examination of the Gallbladder Polyp

담낭 용종의 대사성 증후군 및 생화학적 검사의 연관성

  • 박영준 (의정부척병원 영상의학과)
  • Received : 2015.08.26
  • Accepted : 2015.09.15
  • Published : 2015.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

The gallbladder(GB) polyps have malignant potential and nowadays are increasing due to the extended use of ultrasonography. Even though there are various reports on the risk of GB polyps, there is few study on the relationship between the presence of metabolic syndrome including serum biochemistry, lifestyle and the development of gallbladder polyps in korean population. The aim of this study is to establish a relationship between the presence of metabolic syndrome including serum biochemistry and the development of gallbladder polyps in korean population. This study conducted on 151 men and 167 women who visited a musculoskeletal hospital in Gyeonggido to have an ultrasound scan of the abdomen from November 2, 2012 to January 31, 2014. They are randomly selected to evaluate the prevalence risk factors were analyzed by comparing various variables between the GB polyp positive and negative. The collected data were analyzed using the personal computer program SPSS version 20.0 for windows. The mean size of the GB polyps was 3.92mm in diameter. Size of GB polyps were less than 10mm in diameter. As to frequency in the people with the GB polyps, the number of patients with the GB polyps was 184(57.9%): the number of metabolic syndrome of them was 114(26.4%); these results showed that risk of the GB polyps got higher at patients with metabolic syndrome. As to the risk of the GB polyps, people with the GB polyps had significantly higher risk than those without the GB polyps, as follows: The risk was significantly 1.061 times higher by weight; 1.186 by BMI; 1.060 by systolic blood pressure; 1.030 by diastolic blood pressure; 1,009 by Total cholesterol; 2.736 by metabolic syndrome; 1.011 by blood sugar on an empty stomach; 1.064 by ESR. The risk factors of GB polyps were found to be weight, BMI, total cholesterol, Triglycerol, Glucose, systolic blood pressure, diastolic blood pressure, ESR and metabolic syndrome. This study has a possibility to be used an indicator to identify the GB polyps, and in the future larger-scale study will have to be conducted to objectify it.

최근, 초음파검사로 인해 악성잠재력을 지닌 담낭용종의 발견률이 높아지고 있다. 담낭용종의 위험인자에 대한 다양한 연구가 보고 되었지만 혈청 생화학, 생활습관을 포함한 대사증후군과 담낭용종과의 관계에 대한 연구는 미흡한 실정이다. 본 연구의 목적은 한국에서의 생활습관, 생화학적 혈액검사를 포함한 대사성증후군과 담낭용종인 자간의 상관관계를 알아보는데 있다. 2012년11월2일부터 2014년1월31일까지 경기도내 2차병원을 방문한 151명 남성과 167명 여성을 대상으로 검사를 실행하였다. 이들은 무작위로 차출되었고, 담낭용종 유무에 따른 다양한 변수를 비교하였으며, 수집된 데이터는 Windows 프로그램 SPSS version 20.0을 사용하여 분석하였다. 평균 담낭용종의 크기는 직경이 3.92mm이고 용종의 크기는 직경이 10mm 이하였다. 담낭용종이 발견된 사람은 총184명(57.9%), 그 중 대사성증후군 발견된 사람은 114명(26.4%)으로, 대사성증후군을 가진 사람들에게서 담낭용종의 발생률이 높아짐을 알 수 있었다. 담낭용종에 대한 위험요소에서 체중 1.061배, BMI에서 1.186배, 수축기혈압에서 1.060배, 이완기혈압에서 1.030배, 총콜레스테롤에서 1.009배, 대사성증후군에서 2.736배, 당뇨에서 1.011배, 적혈구침강속도ESR에서 1.064배 높음을 알 수 있었다. 담낭용종의 위험인자는 체중, BMI, 총콜레스테롤, 중성지방, 당뇨, 수축기혈압, 이완기혈압, 적혈구침강속도ESR, 그리고 대사성증후군임을 알 수 있었다. 이 연구는 담낭용종에 대한 연구의 중요한 연구 자료로 사용되고, 차후에 좀 더 대규모의 연구가 이루어져야 할 것이다.

Keywords

References

  1. kim Sang Myeong: The Relationship between the Factions of Metabolic Syndrome and Lifestyle in Adults of a Rural Community, 2008
  2. Statistics Korea: 2014 Cause of Death Statistics (www.kostat.go.kr)
  3. Kuriyama S, Tsubono Y, Hozawa A, Shimazu T, Suzuki Y, Koizumi Y, et al.: Obesity and risk of cancer in Japan. Int J Cancer, Vol.113, 148-57, 2005 https://doi.org/10.1002/ijc.20529
  4. Wolin KY, Carson K, Colditz GA: Obesity and cancer, Oncologist 2010.
  5. Lim SH, Kim DH, Park MJ, et al.: Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?, Gut Liver, Vol.1, 138-44, 2007 https://doi.org/10.5009/gnl.2007.1.2.138
  6. Christensen AH, Ishak KG: Benign tumors and pseudotumors of the gallbladder. Report of 180 cases, Arch Pathol, Vol.90, 423-32, 1970
  7. Kozuka S, Tsubone N, Yasui A, Hachisuka K: Relation of adenoma to carcinoma in the gallbladder, Cancer, Vol:50, 2226-34, 1982 https://doi.org/10.1002/1097-0142(19821115)50:10<2226::AID-CNCR2820501043>3.0.CO;2-3
  8. Kim SY, Lee HS, Lee YS, Chung KW, Jang BK, Chung WJ, et al.: Prevalence and risk factors of gallbladder polyp in adults living in Daegu and Gyeongbuk Provinces. Korean J Gastroenterol, Vol:48, 344-50, 2006
  9. Chen CY, Lu CL, Chang FY, Lee SD: Risk factors for gallbladder polyps in the Chinese population. Am J Gastroenterol Vol:92, 2066-8, 1997
  10. Seo M.J., Seong J.W., Sohn K.J., KO B.J., Han J.H. SM K: Prevalence of the metabolic syndrome in Korean Children and Adolescents: Korea National Health and Nutrition Survey 2001, J korean Acad Fam Med, Vol:27, 798-806, 2006
  11. Segawa K, Arisawa T, Niwa Y, Suzuki T, Tsukamoto Y, Goto H, et al.: Prevalence of gallbladder polyps among apparently healthy Japanese: ultrasonographic study. Am J Gastroenterol, Vol:87, 630-3, 1992
  12. Jorgensen T, Jensen KH: Polyps in the gallbladder. A prevalence study, Scand J Gastroenterol Vol:25, 281-6, 1990
  13. Shim SG, Lee KT, Lee JK, Park JH, Ryu KH, Rhee PL, et al.: Prevalence and risk factors of gallbladder polyps in health screening subjects. Korean J Med Vol:57, 1014-20, 1999
  14. Park mu sin: Clinical characteristics of polypoid lesions of gall bladder, 2011
  15. HJ CH, KY NA, YS KIM, DW CHAE, SW KIM, The impact of uric acid and metabolic syndrome on the incidence of hypertention in a Korean population, koreran Journal of Medicine, Vol:73, 58-66, 2007
  16. Salmenkivi K: Cholesterolosis of the gall-bladder. A clinical study based on 269 cholecystectomies. Acta Chir Scand Vol:105, 1S-93S, 1964
  17. RS, Aro J, Strandberg TE, Lempinen M, Miettinen TA: Lipid composition of bile and gallbladder mucosa in patients with acalculous cholesterolosis. Gastroenterology, Vol:82, 607-15, 1982
  18. Im MY, Lee YR, Han SJ, Cho CMl:The Effects of Lifestyle Factors on Metabolic Syndrome among Korean Adults. Journal of Korean Academy of Community Health Nursing. Vol:23, 13-21, 2012 https://doi.org/10.12799/jkachn.2012.23.1.13
  19. Ministry of Health and Welfare Repulic of korea, Korea Centers for Disease Control and Prevention, 2007-2010(www.mw.go.kr)
  20. Lin WR, Lin DY, Tai DI, et al: Prevalence of and risk factors for gallbladder polyps detected by ultrasonography among healthy Chinese: analysis of 34 669 cases. J Gastroenterol Hepatol, Vol:23, 965-9, 2008 https://doi.org/10.1111/j.1440-1746.2007.05071.x