Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Growth Hormone 1 T1663A Polymorphism, Recreational Physical Activity and BMI, and Breast Cancer Risk in Chinese Women

  • Gao, Chang-Ming (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Ding, Jian-Hua (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Wu, Jian-Shong (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Cao, Hai-Xia (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Li, Su-Ping (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Liu, Yan-Ting (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Tang, Jin-Hai (Division of Epidemiology, Jiangsu Province Institute of Cancer Research) ;
  • Tajima, Kazuo (Dept. of Public Health & Occupational Medicine, Mie University Graduate School of Medicine)
  • Published : 2015.08.03
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Abstract

To evaluate the relationship between the growth hormone 1 (GH1) T1663A polymorphism, recreational physical activity and body mass index (BMI) with reference to breast cancer, we conducted a case-control study with 669 cases of breast cancer and 682 population-based controls in Jiangsu Province, China. A structured questionnaire was used to elicit detailed information. All subjects completed an in-person interview. GH1 genotypes were identified using PCR-RFLP methods. Odds ratios (ORs) were estimated with an unconditional logistic model. The distribution of GH1 genotypes was not significantly different between controls and cases ($x^2$=2.576, P=0.276). Results of stratified analysis by the participation status of the recreational physical activity showed that the persons with GH1 A allele were at a decreased risk of breast cancer (adjusted-OR=0.66; 95% CI, 0.50-0.87) only among inactive individuals. Stratified analysis by BMI showed that the genotype A/A was associated with a decreased risk of breast cancer only among individuals of the BMI <25 (adjusted-OR=0.80; 95% CI, 0.66-0.98). The findings of this study suggest that recreational physical activity and BMI may modify any association between the GH1 T1663A polymorphism and breast cancer risk.

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References

  1. Ahmad T, Geffner M, Parks J, et al (2011). Short stature and metabolic abnormalities in two sisters with a 7.6-kb GH1 gene deletion. Growth Horm IGF Res, 21, 37-43. https://doi.org/10.1016/j.ghir.2010.12.003
  2. Allen NE, Roddam AW, Allen DS, et al (2005). A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk. Br J Cancer, 92, 1283-7. https://doi.org/10.1038/sj.bjc.6602471
  3. Al-Zahrani A, Sandhu MS, Luben RN, et al (2005). IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer. Hum Mol Genet, 15, 1-10. https://doi.org/10.1093/hmg/ddi398
  4. Cianfarani S, Tedeschi B, Germani D et al (1998). In vitro effects of growth hormone (GH) and insulin-like growth factor I and II (IGF-I and-II) on chromosome fragility and p53 protein expression in human lymphocytes. Eur J Clin Invest, 28, 41-7. https://doi.org/10.1046/j.1365-2362.1998.00247.x
  5. Fletcher O, Gibson L, Johnson N, et al (2005). Polymorphisms and circulating levels in the insulinlike growth factor system and risk of breast cancer: a systematic review. Cancer Epidemiol Biomarkers Prev, 14, 2-19,
  6. Florini JR, Ewton DZ, Coolican SA (1996). Growth hormone and the insulin-like growth factor system in myogenesis. Endocr Rev, 17, 481-517.
  7. Gao CM, Gong JP, Wu JZ, et al (2010). Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer. J Human Genetics. 55, 163-6. https://doi.org/10.1038/jhg.2010.3
  8. Gao CM, Tajima K, Ding JH, et al (2009). Body size, physical activity and risk of breast cancer-A case control study in Jangsu Province of China. Asian Pac J Cancer Prev, 10, 877-881.
  9. Hardin DS, Adams-Huet B, Brown D, et al (2006). Growth hormone treatment improves growth and clinical status in prepubertal children with cystic fibrosis: results of a multicenter randomized controlled trial. J Clin Endocrinol Metab, 91, 4925-9. https://doi.org/10.1210/jc.2006-1101
  10. Hasegawa Y, Fujii K, Yamada M, et al (2000). Identification of novel human GH-1 gene polymorphisms that are associated with growth hormone secretion and height. J Clin Endocrinol Metab, 85, 1290-5.
  11. Horan M, Millar DS, Hedderich J, et al (2003). Human growth hormone 1 (GH1) gene expression: complex haplotype-dependent influence of polymorphic variation in the proximal promoter and locus control region. Hum Mutat, 21, 408-23. https://doi.org/10.1002/humu.10167
  12. Jones JI, Clemmons DR (1995). Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev, 16, 3-34.
  13. Kaaks R, Lundin E, Rinaldi S, et al (2002). Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden. Cancer Causes Control, 13, 307-316. https://doi.org/10.1023/A:1015270324325
  14. Khoury-Shakour S, Gruber SB, Lejbkowicz F, et al (2008). Recreational physical activity modifies the association between a common GH1 polymorphism and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev, 17, 3314-8. https://doi.org/10.1158/1055-9965.EPI-08-0062
  15. Laban C, Bustin SA, Jenkins PJ (2003). The GH-IGF-I axis and breast cancer. Trends Endocrinol Metab, 14, 28-34. https://doi.org/10.1016/S1043-2760(02)00003-6
  16. Le Marchand L, Donlon T, Seifried A, et al (2002). Kaaks, R., Rinaldi, S., and Wilkens, L. R. Association of a common polymorphism in the human GH1 gene with colorectal neoplasia. J Natl Cancer Inst, 94, 454-60. https://doi.org/10.1093/jnci/94.6.454
  17. Lukanova A, Toniolo P, Zeleniuch-Jacquotte A, et al (2006). Insulin-like growth factor I in pregnancy and maternal risk of breast cancer. Cancer Epidemiol Biomarkers Prev, 15, 2489-93. https://doi.org/10.1158/1055-9965.EPI-06-0625
  18. Raccurt M, Lobie PE, Moudilou E, et al (2002). High stromal and epithelial human gh gene expression is associated with proliferative disorders of the mammary gland. J Endocrinol, 175, 307-18. https://doi.org/10.1677/joe.0.1750307
  19. Ren Z, Cai Q, Shu XO, et al (2004). Genetic polymorphisms in the human growth hormone-1 gene (GH1) and the risk of breast carcinoma. Cancer, 101, 251-7. https://doi.org/10.1002/cncr.20375
  20. Sachdev D, Yee D (2001). The IGF system and breast cancer. Endocr Relat Cancer, 8, 197-209. https://doi.org/10.1677/erc.0.0080197
  21. Saggese G, Baroncelli GI (2002). Bone status in children and adolescents with growth hormone deficiency: effect of growth hormone treatment. Int J Clin Pract, 126, 18-21.
  22. Schernhammer ES, Holly JM, Pollak MN, et al (2005). Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk. Cancer Epidemiol Biomarkers Prev, 14, 699-704. https://doi.org/10.1158/1055-9965.EPI-04-0561
  23. Schernhammer ES, Holly JM, Hunter DJ, et al (2006). Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II. Endocr Relat Cancer, 13, 583-92. https://doi.org/10.1677/erc.1.01149
  24. Shi J, Tong JH, Cai S(2014). GH1 T1663A polymorphism and cancer risk: a meta-analysis of case-control studies. Tumour Biol, 35, 4529-38. https://doi.org/10.1007/s13277-013-1596-z
  25. Sugiyama M, Takenaga F, Kitani Y, et al (2012). Homozygous and heterozygous GH transgenesis alters fatty acid composition and content in the liver of Amago salmon (Oncorhynchus masou ishikawae). Biol Open, 1, 1035-42. https://doi.org/10.1242/bio.20121263
  26. van Heemst D, Beekman M, Mooijaart SP, et al (2005). Reduced insulin/IGF-1 signalling and human longevity. Aging Cell, 4, 79-85. https://doi.org/10.1111/j.1474-9728.2005.00148.x
  27. Wagner K, Hemminki K, Forsti A (2007). The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development. Breast Cancer Res Treat, 104, 233-48. https://doi.org/10.1007/s10549-006-9411-9
  28. Wolk A, Mantzoros CS, Andersson SO, et al (1998). Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. J Natl Cancer Inst, 90, 911-5. https://doi.org/10.1093/jnci/90.12.911
  29. Wood TL, Yee D (2000). Introduction: IGFs and IGFBPs in the normal mammary gland and in breast cancer. J Mammary Gland Biol Neoplasia, 5, 1-5. https://doi.org/10.1023/A:1009580913795
  30. Yang XF, Beamer WG, Huynh H, et al (1996). Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation. Cancer Res, 56, 1509-11.
  31. Yu H, Rohan T (2000). Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst, 92, 1472-89. https://doi.org/10.1093/jnci/92.18.1472