Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Factors Prognostic for Survival in Japanese Patients Treated with Sunitinib as First-line Therapy for Metastatic Clear Cell Renal Cell Cancer

  • Kawai, Y (Department of Urology, Graduate School of Medicine, Yamaguchi University) ;
  • Osawa, T (Department of Urology, Hokkaido Cancer Center) ;
  • Kobayashi, K (Department of Urology, Graduate School of Medicine, Yamaguchi University) ;
  • Inoue, R (Department of Urology, Graduate School of Medicine, Yamaguchi University) ;
  • Yamamoto, Y (Department of Urology, Graduate School of Medicine, Yamaguchi University) ;
  • Matsumoto, H (Department of Urology, Graduate School of Medicine, Yamaguchi University) ;
  • Nagao, K (Department of Urology, Graduate School of Medicine, Yamaguchi University) ;
  • Hara, T (Department of Urology, Graduate School of Medicine, Yamaguchi University) ;
  • Sakano, S (Department of Urology, Graduate School of Medicine, Yamaguchi University) ;
  • Nagamori, S (Department of Urology, Hokkaido Cancer Center) ;
  • Matsuyama, H (Department of Urology, Graduate School of Medicine, Yamaguchi University)
  • Published : 2015.09.02
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Abstract

Background: Factors predictive of survival have been identified in Western patients with metastatic clear cell renal cell carcinoma (mCCRCC) treated with sunitinib. Less is known, however, about factors predictive of survival in Japanese patients. This study evaluated factors prognostic of survival in Japanese patients with mCCRCC treated with first-line sunitinib. Materials and Methods: This retrospective study evaluated 46 consecutive Japanese mCCRCC patients treated with sunitinib as first line therapy. Clinical and biochemical markers associated with progression-free survival (PFS) were analyzed, with prognostic factors selected by uniand multivariate Cox regression analyses. Results: Univariate analysis showed that factors significantly associated with poor PFS included Memorial Sloan-Kettering Cancer Center poor risk scores, International Metastatic RCC Database Consortium poor risk and high (>0.5 mg/dl) serum C-reactive protein (CRP) concentrations (p<0.001 each). Multivariate analysis showed that high serum CRP was independently associated with poorer PFS (p=0.040). Six month disease control rate (complete response, partial response and stable disease) in response to sunitinib was significantly higher in patients with normal (${\leq}0.5mg/dl$) than elevated baseline CRP (p<0.001). Conclusions: CRP is a significant independent predictor of PFS for Japanese patients with mCCRCC treated with first-line sunitinib. Pretreatment CRP concentration may be a useful biomarker predicting response to sunitinib treatment.

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References

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