Asian Pacific Journal of Cancer Prevention

  • 제16권5호
  • /
  • Pages.2055-2060
  • /
  • 2015
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Treatment Outcomes and Survival Study of Gastric Cancer Patients: A Retrospective Analysis in an Endemic Region

  • Basaran, Hamit (Department of Radiation Oncology, Erzurum Regional Training and Research Hospital) ;
  • Koca, Timur (Department of Radiation Oncology, Erzurum Regional Training and Research Hospital) ;
  • Cerkesli, Arda Kaymak (Department of Radiation Oncology, Erzurum Regional Training and Research Hospital) ;
  • Arslan, Deniz (Department of Medical Oncology, Erzurum Regional Training and Research Hospital) ;
  • Karaca, Sibel (Department of Radiation Oncology, Erzurum Regional Training and Research Hospital)
  • 발행 : 2015.03.18
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: To present information about prognostic factors of gastric cancer patients treated in our Erzurum center including age, gender, tumour location, pathological grade, stage and the effect of treatment on survival. Materials and Methods: This retrospective study was performed on patients who applied to our clinic and diagnosed as gastric cancer. Age and gender of the patients, primary location, histopathological characteristics, TNM stage of the gastric cancers (GCs), treatment applied, oncological treatment modalities and survival outcomes were studied. A univariate analysis of potential prognostic factors was performed with the log-rank test for categorical factors and parameters with a p value < 0.05 at the univariate step were included in the multivariate regression. Results: A total of 228 patients with a confirmed diagnosis of gastric cancer were included in the study with a male/female ratio of 1.47. Median follow-up period was estimated as 22.3 (range, 3 to 96) months. When diagnosis of the patients at admission was analysed, stage III patients were most frequently encountered (n=147; 64.5%). One hundred and twenty-six (55.3%) underwent surgical treatment, while 117 (51.3%) were given adjuvant chemotherapy. Median overall survival time was 18.0 (${\pm}1.19$) months. Mean overall survival rates for 1, 2, 3 and 5 years were $68{\pm}0.031%$, $36{\pm}0.033%$, $24{\pm}0.031%$and $15.5{\pm}0.036%$, respectively. Univariate variables found to be significant for median OS in the multivariate analysis were evaluated with Cox regression analysis. A significant difference was found among TNM stage groups, location of the tumour and postoperative adjuvant treatment receivers (p values were 0.011, 0.025 and 0.001, respectively). Conclusions: This study revealed that it is possible to achieve long-term survival of gastric cancer with early diagnosis. Besides, in locally advanced GC patients, curative resection followed by adjuvant concomitant chemoradiotherapy based on the McDonald regimen was an independent prognostic factor for survival.

키워드

참고문헌

  1. Alimoghaddam K, Jalali A, Aliabadi LS, et al (2014). The outcomes of esophageal and gastric cancer treatments in a retrospective study, single center experience. Int J Hematol Oncol Stem Cell Res, 8, 9-13.
  2. Bamias A, Pavlidis N(1998). Systemic chemotherapy in gastric cancer: where do we stand today? Oncologist, 3, 171-7.
  3. Chandanos E, Lagergren J(2008). Oestrogen and the enigmatic male predominance of gastric cancer. Eur J Cancer, 44, 2397-403. https://doi.org/10.1016/j.ejca.2008.07.031
  4. Dogan NB, Timur K, Hakan D(2009). Dietary habits, demographical, and socio-economical risk factors of the newly diagnosed gastric cancers in the eastern anatolia region of turkey: an endemic upper gastrointestinal cancer region. Dig Dis Sci, 54, 2629-33. https://doi.org/10.1007/s10620-008-0647-6
  5. Elimova E, Shiozaki H, Wadhwa R, et al (2014). Medical management of gastric cancer: A 2014 update. World J Gastroenterol, 20, 13637-47. https://doi.org/10.3748/wjg.v20.i38.13637
  6. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistic. CA Cancer J Clin, 61, 69. https://doi.org/10.3322/caac.20107
  7. Kim S, Kim JS, Jeong HY, et al (2011). Retrospective analysis of treatment outcomes after postoperative chemoradiotherapy in advanced gastric cancer. Radiat Oncol J, 29, 252-9. https://doi.org/10.3857/roj.2011.29.4.252
  8. Kim S, Lim DH, Lee J, et al (2005). An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach. Int J Radiat Oncol Biol Phys, 63, 1279-85. https://doi.org/10.1016/j.ijrobp.2005.05.005
  9. Lin WL, Sun JL, Chang SC, et al (2014). Factors predicting survival of patients with gastric cancer. Asian Pac J Cancer Prev, 15, 5835-8. https://doi.org/10.7314/APJCP.2014.15.14.5835
  10. Macdonald JS, Smalley SR, Benedetti J, et al (2001). Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med, 345, 725-30. https://doi.org/10.1056/NEJMoa010187
  11. Misirlioglu HC, Coskun-Breuneval M, Kucukpilakci B, et al (2014). Adjuvant radiotherapy for gastric carcinoma: 10 years follow-up of 244 cases from a single institution. Asian Pac J Cancer Prev, 15, 8871-6. https://doi.org/10.7314/APJCP.2014.15.20.8871
  12. Parkin DM, Bray F, Ferlay J, et al (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  13. Peleteiro B, Lopes C, et al (2011). Salt intake and gastric cancer risk according to Helicobacter pylori infection, smoking, tumour site and histological type. Br J Cancer, 104, 198. https://doi.org/10.1038/sj.bjc.6605993
  14. Pisani P, Parkin DM, Bray F, Feraly J (1999). Estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer, 83, 18-29. https://doi.org/10.1002/(SICI)1097-0215(19990924)83:1<18::AID-IJC5>3.0.CO;2-M
  15. Seker M, Aksoy S, et al (2013). Clinicopathologic features of gastric cancer in young patients. Saudi J Gastroenterol, 19, 258-61. https://doi.org/10.4103/1319-3767.120876
  16. Selcukbiricik F, Buyukunal E, Tural D, et al (2013). Clinicopathological features and outcomes of patients with gastric cancer: a single-center experience. World J Gastroenterol, 19, 2154-61. https://doi.org/10.3748/wjg.v19.i14.2154
  17. Seyedin S, Wang P, Zhang Q, Lee P(2014). Benefit of adjuvant chemoradiotherapy for gastric adenocarcinoma:a seer population analysis. Gastrointest Cancer Res, 7, 82-90.
  18. Shikata K, Kiyohara Y, Kubo M, et al (2006). A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: the Hisayama study. Int J Cancer, 119, 196. https://doi.org/10.1002/ijc.21822
  19. Tong GX, Liang H, Chai J, et al (2014). Association of risk of gastric cancer and consumption of tobacco, alcohol and tea in the Chinese population. Asian Pac J Cancer Prev, 15, 8765-74. https://doi.org/10.7314/APJCP.2014.15.20.8765
  20. Tsugane S, Sasazuki S, et al (2007). Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer, 10, 75. https://doi.org/10.1007/s10120-007-0420-0
  21. Wang Z, Ma L, Zhang XM, Zhou ZX(2014). Long-term outcomes after D2 gastrectomy for early gastric cancer: survival analysis of a single-center experience in China. Asian Pac J Cancer Prev, 15, 7219-22. https://doi.org/10.7314/APJCP.2014.15.17.7219
  22. Watanabe T, Tada M, et al (1998). Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology, 115, 642. https://doi.org/10.1016/S0016-5085(98)70143-X
  23. Yan S, Li B, Bai ZZ, et al (2014).Clinical epidemiology of gastric cancer in Hehuang valley of China: a 10 year epidemiological study of gastric cancer. World J Gastroenterol, 20, 10486-94. https://doi.org/10.3748/wjg.v20.i30.10486
  24. Yang D, Hendifar A, Lenz C, et al (2011). Survival of metastatic gastric cancer: Significance of age, sex and race/ethnicity. J Gastrointest Oncol, 2,77-84.
  25. Yu J, He Y, Guo Z(2014). Age trend of the male to female sex ratio in surgical gastric cancer patients at a single institution. World J Surg Oncol, 12, 269. https://doi.org/10.1186/1477-7819-12-269
  26. Zeng WJ, Hu WQ ,Wang LW, et al (2014). Long term follow up and retrospective study on 533 gastric cancer cases. BMC Surg, 14, 29. https://doi.org/10.1186/1471-2482-14-29
  27. Zhu AL, Sonnenberg A(2012). Is gastric cance ragain rising? J Clin Gastroenterol, 46, 804-6. https://doi.org/10.1097/MCG.0b013e3182604254

피인용 문헌

  1. Individualized Chemotherapy for Metastatic Gastric Cancer: Retrospective Data from a University Hospital in Brazil vol.16, pp.13, 2015, https://doi.org/10.7314/APJCP.2015.16.13.5289
  2. Relationship of Amplification and Expression of the C-MYC Gene with Survival among Gastric Cancer Patients vol.16, pp.16, 2015, https://doi.org/10.7314/APJCP.2015.16.16.7061
  3. Sensitivity of Gastric Cancer Cells to Chemotherapy Drugs in Elderly Patients and Its Correlation with Cyclooxygenase-2 Expression vol.16, pp.8, 2015, https://doi.org/10.7314/APJCP.2015.16.8.3447
  4. Overall Survival Is Impacted by Birthplace and Not Extent of Surgery in Asian Americans with Resectable Gastric Cancer vol.19, pp.11, 2015, https://doi.org/10.1007/s11605-015-2919-8
  5. How does epidemiological and clinicopathological features affect survival after gastrectomy for gastric cancer patients-single Egyptian center experience vol.8, pp.6, 2016, https://doi.org/10.4240/wjgs.v8.i6.444
  6. Comparison of East and West Survival Nomograms in Turkish Gastric Cancer Patients Who Underwent Radical Surgery pp.1799-7267, 2018, https://doi.org/10.1177/1457496918766724