Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Value of the Platelet to Lymphocyte Ratio in the Diagnosis of Ovarian Neoplasms in Adolescents

  • Ozaksit, Gulnur (Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital) ;
  • Tokmak, Aytekin (Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital) ;
  • Kalkan, Hatice (Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital) ;
  • Yesilyurt, Huseyin (Obstetrics and Gynecology, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital)
  • Published : 2015.03.18
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Relationships between poor prognosis of ovarian malignancies and changes in complete blood count parameters have been proposed previously. In this work, we aimed to evaluate clinicopathologic features in adolescents with adnexal masses and sought to establish any predictive value of the platelet to lymphocyte ratio (PLR) in diagnosis. Materials and Methods: This retrospective study was conducted on 196 adolescent females with adnexal masses. Three groups were constituted with respect to clinical or histopathology results: group 1, non-neoplastic patients (n:65); group 2, neoplastic patients (n:68); and group 3 expectantly managed patients (n:63). The main parameters recorded from the hospital database and patient files were age, body mass index (BMI), chief symptoms, diameter of the mass (DOM), tumor marker levels, complete blood count values including absolute neutrophil, lymphocyte, and platelet counts, mean platelet volume, platelet distribution width, and platecrit, surgical features, and postoperative histopathology results. Results: The expectantly managed patients were younger than the other groups (p=0.007). The mean body mass index (BMI) was higher in the neoplastic group (p=0.016). Preoperative DOM, CA125, mean platelet volume and PLR were statistically significantly different between the groups (p<0.05). ROC curve analysis demonstrated that increased PLR (AUC, 0.609; p=0.011) and BMI (AUC, 0.611; p=0.011) may be discriminative factors in predicting ovarian neoplasms in adolescents preoperatively. When the cut-off point for the PLR level was set to 140, the sensitivity and specificity levels were found to be 65.7% and 57.6%, respectively. Conclusions: We suggest that beside a careful preoperative evaluation including clinical characteristics, ultrasonographic features and tumor markers, PLR may predict ovarian neoplasms in adolescents.

Keywords

References

  1. Acmaz G, Aksoy H, Unal D, et al (2014). Are neutrophil/ lymphocyte and platelet/lymphocyte ratios associated with endometrial precancerous and cancerous lesions in patients with abnormal uterine bleeding? Asian Pac J Cancer Prev, 15, 1689-92. https://doi.org/10.7314/APJCP.2014.15.4.1689
  2. Arab M, Honarvar Z, Hosseini-Zijoud SM (2014). Ovarian malignancy probability score (OMPS) for appropriate referral of adnexal masses. Asian Pac J Cancer Prev, 15, 8647-50. https://doi.org/10.7314/APJCP.2014.15.20.8647
  3. Deligeoroglou E, Eleftheriades M, Shiadoes V, et al (2004). Ovarian masses during adolescence: clinical, ultrasonographic and pathologic findings, serum tumor markers and endocrinological profile. Gynecol Endocrinol, 19, 1-8. https://doi.org/10.1080/09513590410001712895
  4. Hassan E, Creatsas G, Deligeorolgou E, Michalas S (1999). Ovarian tumors during childhood and adolescence. A clinicopathological study. Eur J Gynaecol Oncol, 20, 124-6.
  5. Kaur T, Zhang ZF (2005). Obesity, breast cancer and the role of adipocytokines. Asian Pac J Cancer Prev, 6, 547-52.
  6. Kemal Y, Yucel I, Ekiz K, et al (2014). Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis. Asian Pac J Cancer Prev, 15, 2651-4. https://doi.org/10.7314/APJCP.2014.15.6.2651
  7. Ki EY, Byun SW, Choi YJ, et al (2013). Clinicopathologic review of ovarian masses in Korean premenarchal girls. Int J Med Sci, 10, 10611-7.
  8. Kokcu A, Kurtoglu E, Celik H, Tosun M, Malatyalioglu E, Ozdemir AZ (2014). May the platelet to lymphocyte ratio be a prognostic factor for epithelial ovarian cancer? Asian Pac J Cancer Prev, 15, 9781-4. https://doi.org/10.7314/APJCP.2014.15.22.9781
  9. Leitzmann MF, Koebnick C, Danforth KN, et al (2009). Body mass index and risk of ovarian cancer. Cancer, 115, 812-22. https://doi.org/10.1002/cncr.24086
  10. Liu H, Wang X, Lu D, Liu Z, Shi G (2013). Ovarian masses in children and adolescents in China: analysis of 203 cases. J Ovarian Res, 6, 47. https://doi.org/10.1186/1757-2215-6-47
  11. Mayer JP, Bettolli M, Kolberg-Schwerdt A, et al (2009). Laparoscopic approach to ovarian mass in children and adolescents: already a standard in therapy. J Laparoendosc Adv Surg Tech A, 1, 111-5.
  12. McCarthy JD, Erickson KM, Smith YR, Quint EH (2010). Premenarchal ovarian torsion and elevated CA-125. J Pediatr Adolesc Gynecol, 23, 47-50. https://doi.org/10.1016/j.jpag.2009.04.002
  13. Olsen CM, Green AC, Whiteman DC, et al (2007). Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Eur J Cancer, 43, 690-709. https://doi.org/10.1016/j.ejca.2006.11.010
  14. Raungkaewmanee S, Tangjitgamol S, Manusirivithaya S, Srijaipracharoen S, Thavaramara T (2012). Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer. J Gynecol Oncol, 23, 265-73. https://doi.org/10.3802/jgo.2012.23.4.265
  15. Rousseau V, Massicot R, Darwish AA, et al (2008). Emergency management and conservative surgery of ovarian torsion in children: a report of 40 cases. J Pediatr Adolesc Gynecol, 21, 201-6. https://doi.org/10.1016/j.jpag.2007.11.003
  16. Shah AA, Likes CE, Price TM (2009). Early polycystic ovary syndrome as a possible etiology of unexplained premenarcheal ovarian torsion. J Pediatr Adolesc Gynecol, 22, 265-9. https://doi.org/10.1016/j.jpag.2008.11.005
  17. Templeman C, Fallat ME, Blinchevsky A, Hertweck SP (2000). Noninflammatory ovarian masses in girls and young women. Obstet Gynecol, 96, 229-33. https://doi.org/10.1016/S0029-7844(00)00929-7
  18. Yesilyurt H, Tokmak A, Guzel AI, et al (2014). Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. Asian Pac J Cancer Prev, 15, 8447-50. https://doi.org/10.7314/APJCP.2014.15.19.8447
  19. Yildirim MA, Seckin KD, Togrul C, et al (2014). Roles of neutrophil/lymphocyte and platelet/lymphocyte ratios in the early diagnosis of malignant ovarian masses. Asian Pac J Cancer Prev, 15, 6881-5. https://doi.org/10.7314/APJCP.2014.15.16.6881
  20. Zhang M, Jiang W, Li G, Xu C (2014). Ovarian masses in children and adolescents-an analysis of 521 clinical cases. J Pediatr Adolesc Gynecol, 27, 73-7. https://doi.org/10.1016/j.jpag.2013.07.007

Cited by

  1. Evaluation of Platelet Indices in Lung Cancer Patients vol.16, pp.17, 2015, https://doi.org/10.7314/APJCP.2015.16.17.7599
  2. May the Neutrophil/Lymphocyte Ratio Be a Predictor in the Differentiation of Different Thyroid Disorders? vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.3875
  3. Update on the surgical management of ovarian neoplasms in children and adolescents: analysis on 32 cases vol.32, pp.10, 2016, https://doi.org/10.1080/09513590.2016.1190819
  4. High neutrophil-to-lymphocyte ratio is associated with increased carotid artery intima-media thickness in type 2 diabetes vol.8, pp.1, 2017, https://doi.org/10.1111/jdi.12541
  5. The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis vol.20, pp.5, 2017, https://doi.org/10.1080/13697137.2017.1326894
  6. The diagnostic efficacy of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in ovarian cancer vol.66, pp.6, 2017, https://doi.org/10.1007/s00011-017-1026-6
  7. Use of the Monocyte-to-Lymphocyte Ratio to Predict Diabetic Retinopathy vol.12, pp.8, 2015, https://doi.org/10.3390/ijerph120810009
  8. The Predictive Value of Inflammation-Related Peripheral Blood Measurements in Cancer Staging and Prognosis vol.8, pp.2234-943X, 2018, https://doi.org/10.3389/fonc.2018.00078