Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Significant Association of Alpha-Methylacyl-CoA Racemase Gene Polymorphisms with Susceptibility to Prostate Cancer: a Meta-Analysis

  • Chen, Nan (West China School of Medicine, West China Hospital, Sichuan University) ;
  • Wang, Jia-Rong (West China School of Medicine, West China Hospital, Sichuan University) ;
  • Huang, Lin (West China School of Medicine, West China Hospital, Sichuan University) ;
  • Yang, Yang (West China School of Medicine, West China Hospital, Sichuan University) ;
  • Jiang, Ya-Mei (West China School of Medicine, West China Hospital, Sichuan University) ;
  • Guo, Xiao-Jiang (West China School of Medicine, West China Hospital, Sichuan University) ;
  • He, Ya-Zhou (West China School of Medicine, West China Hospital, Sichuan University) ;
  • Zhou, Yan-Hong (Department of Laboratory Medicine, West China Hospital, Sichuan University)
  • Published : 2015.03.18
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Alpha-methylacyl-CoA racemase(AMACR) is thought to play key roles in diagnosis and prognosis of prostate cancer. However, studies of associations between AMACR gene polymorphisms and prostate cancer risk reported inconsistent results. Therefore, we conducted the present meta-analysis to clarify the link between AMACR gene polymorphisms and prostate cancer risk. Materials and Methods: A literature search was performed in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu databases. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated to assess the strength of any association between AMACR polymorphisms and prostate cancer risk. Subgroup analyses by ethnicity, source of controls, quality control and sample size were also conducted. Results: Five studies covering 3,313 cases and 3,676 controls on five polymorphisms (D175G, M9V, S201L, K277E and Q239H) were included in this meta-analysis. Significant associations were detected between prostate cancer and D175G (dominant model: OR=0.89, 95%CI=0.80-0.99, P=0.04) and M9V (dominant model: OR=0.87, 95%CI=0.78-0.97, P=0.01) polymorphisms as well as that in subgroup analyses. We also observed significant decreased prostate cancer risk in the dominant model (OR=0.90, 95%CI=0.81-0.99, P=0.04) for the S201L polymorphism. However, K277E and Q239H polymorphisms did not appear to be related to prostate cancer risk. Conclusions: The current meta-analysis indicated that D175G and M9V polymorphisms of the AMACR gene are related to prostate cancer. The S201L polymorphism might also be linked with prostate cancer risk to some extent. However, no association was observed between K277E or Q239H polymorphisms and susceptibility to prostate cancer.

Keywords

References

  1. Amankwah EK, Sellers TA, Park JY, (2012). Gene variants in the angiogenesis pathway and prostate cancer. Carcinogenesis, 33, 1259-69. https://doi.org/10.1093/carcin/bgs150
  2. Askari F, Parizi MK, Jessri M, Rashidkhani B (2014). Dietary patterns in relation to prostate cancer in Iranian Men: A Case-Control Study. Asian Pac J Cancer Prev, 15, 2159-63. https://doi.org/10.7314/APJCP.2014.15.5.2159
  3. Daugherty SE, Shugart YY, Platz EA, et al (2007). Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancer. Prostate, 67, 1487-97. https://doi.org/10.1002/pros.20635
  4. Doolan G, Benke G, Giles G (2014). An update on occupation and prostate cancer. Asian Pac J Cancer Prev, 15, 501-16. https://doi.org/10.7314/APJCP.2014.15.2.501
  5. Ferdinandusse S, Denis S, L IJ, et al (2000). Subcellular localization and physiological role of alpha-methylacyl-CoA racemase. J Lipid Res, 41, 1890-96.
  6. FitzGerald LM, Thomson R, Polanowski A, et al (2008). Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk: a replication study in an ethnically homogeneous population. Prostate, 68, 1373-79. https://doi.org/10.1002/pros.20798
  7. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  8. Jiang N, Zhu S, Chen J, Niu Y, Zhou L (2013). A-methylacyl- CoA racemase (AMACR) and prostate-cancer risk: a metaanalysis of 4,385 participants. PLoS One, 8, 74386. https://doi.org/10.1371/journal.pone.0074386
  9. Lee SJ, Joung JY, Yoon H, et al (2013). Genetic variations of alpha -methylacyl-CoA racemase are associated with sporadic prostate cancer risk in ethnically homogenous Koreans. Biomed Res Int, 2013, 394285.
  10. Lloyd MD, Yevglevskis M, Lee GL, et al (2013). alpha- Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S. Prog Lipid Res, 52, 220-30. https://doi.org/10.1016/j.plipres.2013.01.001
  11. Mahmoud AM, Yang W, Bosland MC (2014). Soy isoflavones and prostate cancer: a review of molecular mechanisms. J Steroid Biochem Mol Biol, 140, 116-32. https://doi.org/10.1016/j.jsbmb.2013.12.010
  12. Mazzola CR, Ghoneim T, Shariat SF, (2011). Emerging biomarkers for the diagnosis, staging and prognosis of prostate cancer. Prog Urol, 21, 1-10. https://doi.org/10.1016/j.purol.2010.07.004
  13. Ouyang B, Leung YK, Wang V, et al (2011). Alpha-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues. Urology, 77, 249.e1-249.e7.
  14. Wang YC, Xia SJ (2009). An update of biomarkers in prostate cancer tissue. Zhonghua Nan Ke Xue, 15, 1039-43.
  15. Wright JL, Neuhouser ML, Lin DW, et al (2011). AMACR polymorphisms, dietary intake of red meat and dairy and prostate cancer risk. Prostate, 71, 498-506. https://doi.org/10.1002/pros.21267
  16. Yang B, Chen WH, Wen XF, Liu H, Liu F (2013). Role of DNA repair-related gene polymorphisms in susceptibility to risk of prostate cancer. Asian Pac J Cancer Prev, 14, 5839-42. https://doi.org/10.7314/APJCP.2013.14.10.5839
  17. Zhang LL, Sun L, Zhu XQ, et al (2014). rs10505474 and rs7837328 at 8q24 cumulatively confer risk of prostate cancer in Northern Han Chinese. Asian Pac J Cancer Prev, 15, 3129-32. https://doi.org/10.7314/APJCP.2014.15.7.3129
  18. Zha S, Ferdinandusse S, Denis S, et al (2003). Alpha-methylacyl- CoA racemase as an androgen-independent growth modifier in prostate cancer. Cancer Res, 63, 7365-76.
  19. Zheng SL, Chang BL, Faith DA, et al (2002). Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk. Cancer Res, 62, 6485-8.