Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Association between the NQO1 C609T Polymorphism with Hepatocellular Carcinoma Risk in the Chinese Population

  • Zhao, Hong (Department of Radiology, Institute: the Second Hospital of Anhui Medical University) ;
  • Zou, Li-Wei (Department of Radiology, Institute: the Second Hospital of Anhui Medical University) ;
  • Zheng, Sui-Sheng (Department of Radiology, Institute: the Second Hospital of Anhui Medical University) ;
  • Geng, Xiao-Ping (Department of Radiology, Institute: the Second Hospital of Anhui Medical University)
  • Published : 2015.03.18
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Abstract

Background: Associations between the NQO1 C609T polymorphism and hepatocellular carcinoma (HCC) risk are a subject of debate. We therefore performed the present meta-analysis to evaluate links with HCC susceptibility. Materials and Methods: Several major databases (PubMed, EBSCO), the Chinese national knowledge infrastructure (CNKI) and the Wanfang database were searched for eligible studies. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the strength of associations. Results: A total of 4 studies including 1,325 patients and 1,367 controls were identified. There was a significant association between NQO1 C609T polymorphism and HCC for all genetic models (allelic model: OR=1.45, 95%CI=1.23-1.72, p<0.01; additive model: OR=1.96, 95%CI=1.57-2.43, p<0.01; dominant model: OR=1.62, 95%CI=1.38-1.91, p<0.01; and recessive model: OR=1.53, 95%CI=1.26-1.84, p<0.01). On subgroup analysis, similarly results were identified in Asians. For Asians, the combined ORs and 95% CIs were (allelic model: OR=1.50, 95%CI=1.24-1.82, p<0.01; additive model: OR=2.11, 95%CI=1.48-3.01, p<0.01; dominant model: OR=1.69, 95%CI=1.42-2.02, p<0.01; and recessive model: OR=1.59, 95%CI=1.16-2.19, p<0.01). Conclusions: The current meta-analysis suggested that the NQO1 C609T polymorphism could be a risk factor for developing HCC, particularly in the Chinese population.

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References

  1. Akkiz H, Bayram S, Bekar A, et al (2010). No association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and risk of hepatocellular carcinoma development in Turkish subjects. Asian Pac J Cancer Prev, 11, 1051-8.
  2. Bowen DG, Walker CM (2005). Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature, 436, 946-52. https://doi.org/10.1038/nature04079
  3. de Lope CR, Tremosini S, Forner A, et al (2012). Management of HCC. J Hepatol, 56, 75-87.
  4. Dinkova-Kostova AT, Talalay P (2010). NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. Arch Biochem Biophys, 501, 116-23. https://doi.org/10.1016/j.abb.2010.03.019
  5. Egger M, Davey Smith G, Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  6. El-Serag HB, Rudolph KL (2007). Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557-76. https://doi.org/10.1053/j.gastro.2007.04.061
  7. Farazi PA, DePinho RA (2006). Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer, 6, 674-87. https://doi.org/10.1038/nrc1934
  8. Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
  9. Hu X, Zhang Z, Ma D, et al (2010). TP53, MDM2, NQO1, and susceptibility to cervical cancer. Cancer Epidemiol Biomarkers Prev, 19, 755-61. https://doi.org/10.1158/1055-9965.EPI-09-0886
  10. Kato N, Ji G, Wang Y, et al (2005). Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C. Hepatology, 42, 846-53. https://doi.org/10.1002/hep.20860
  11. Kim YJ, Lee HS (2005). Single nucleotide polymorphisms associated with hepatocellular carcinoma in patients with chronic hepatitis B virus infection. Intervirology, 48, 10-5. https://doi.org/10.1159/000082089
  12. Lau J, Ioannidis JP, Schmid CH (1997). Quantitative synthesis in systematic reviews. Ann Intern Med, 127, 820-6. https://doi.org/10.7326/0003-4819-127-9-199711010-00008
  13. Liu F, Luo L, Wei Y, et al (2013). A functional NQO1 609C>T polymorphism and risk of hepatocellular carcinoma in a Chinese population. Tumour Biol, 34, 47-53. https://doi.org/10.1007/s13277-012-0509-x
  14. Malik MA, Zargar SA, Mittal B (2011). Role of NQO1 609C>T and NQO2-3423G>A polymorphisms in susceptibility to gastric cancer in Kashmir valley. DNA Cell Biol, 30, 297-303. https://doi.org/10.1089/dna.2010.1115
  15. Mandal RK, Nissar K, Mittal RD (2012). Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India. Mol Biol Rep, 39, 11145-52. https://doi.org/10.1007/s11033-012-2023-z
  16. Moher D, Liberati A, Tetzlaff J, et al (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med, 151, 264-9. https://doi.org/10.7326/0003-4819-151-4-200908180-00135
  17. Parkin DM (2001). Global cancer statistics in the year 2000. Lancet Oncol, 2, 533-43. https://doi.org/10.1016/S1470-2045(01)00486-7
  18. Peng XE, Jiang YY, Shi XS, et al (2013). NQO1 609C>T polymorphism interaction with tobacco smoking and alcohol drinking increases colorectal cancer risk in a Chinese population. Gene, 521, 105-10. https://doi.org/10.1016/j.gene.2013.02.029
  19. Siegel D, Yan C, Ross D (2012). NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol, 83, 1033-40. https://doi.org/10.1016/j.bcp.2011.12.017
  20. Tan SK, Qiu XQ, Tang GF, et al (2012). Relationship between hepatocellular carcinoma and the interaction between NQO1 polymorphisms and environmental factors. Zhonghua Gan Zang Bing Za Zhi, 20, 833-7.
  21. Traver RD, Siegel D, Beall HD, et al (1997). Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase). Br J Cancer, 75, 69-75. https://doi.org/10.1038/bjc.1997.11
  22. Wang WW, Chen GY, Sun JJ, et al (2013). The relationship between polymorphisms of NQO1 genes and hepatocellular carcinoma in Zhengzhou and Guilin areas. Chin J Hepatobiliary Surg, 19, 836-40.
  23. Yuan W, Xu L, Chen W, et al (2011). Evidence on the association between NQO1 Pro187Ser polymorphism and breast cancer risk in the current studies: a meta-analysis. Breast Cancer Res Treat, 125, 467-72. https://doi.org/10.1007/s10549-010-0966-0
  24. Yuen MF, Hou JL, Chutaputti A, et al (2009). Hepatocellular carcinoma in the Asia pacific region. J Gastroenterol Hepatol, 24, 346-53. https://doi.org/10.1111/j.1440-1746.2009.05784.x