DOI QR코드

DOI QR Code

Nanoparticles Promise New Methods to Boost Oncology Outcomes in Breast Cancer

  • Islamian, Jalil Pirayesh (Department of Medical Physics, Faculty of Medicine, Tabriz University of Medical Sciences) ;
  • Hatamian, Milad (Department of Medical Physics, Faculty of Medicine, Tabriz University of Medical Sciences) ;
  • Rashidi, Mohammad Reza (Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences)
  • Published : 2015.03.18

Abstract

Different types of treatment are available for patients with breast cancer, the most being radiotherapy, chemotherapy, hormonal therapy and combination therapy. Recently, nanoparticles have been emerging as promising agents for cancer therapy and are being investigated as contrast agents, drug carriers, radiosensitizers and also for hyperthermia effects. In this review the focus is on approaches for targeted treatment of breast cancer by combining nanoparticles, chemodrugs and radiation. The availble data suggest the possibility of increased roles for combined therapy, particularly by reducing the dose of each treatment modality, and consequently minimizing related side effects.

Keywords

References

  1. Aghaee F, Islamian JP, Baradaran B, et al (2013). Enhancing the effects of low dose doxorubicin treatment by the radiation in T47D and SKBR3 breast cancer cells. J Breast Cancer, 16, 164-70. https://doi.org/10.4048/jbc.2013.16.2.164
  2. Aghaee F, Pirayesh Islamian J, Baradaran B (2012). Enhanced radiosensitivity and chemosensitivity of breast cancer cells by 2-deoxy-d-glucose in combination therapy. J Breast Cancer, 15, 141-7. https://doi.org/10.4048/jbc.2012.15.2.141
  3. Ahmad IM, Mustafa EH, Mustafa NH, et al (2010). 2DG enhances the susceptibility of breast cancer cells to doxorubicin. Cent Eur J Biol, 5, 739-48.
  4. Aydogan B, Li J, Rajh T, et al (2010). AuNP-DG: deoxyglucoselabeled gold nanoparticles as X-ray computed tomography contrast agents for cancer imaging. Mol Imaging Biol, 12, 463-7. https://doi.org/10.1007/s11307-010-0299-8
  5. Basel MT, Balivada S, Wang H, et al (2012). Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model. Int J Nanomedicine, 7, 297.
  6. Casciaro S, Conversano F, Ragusa A, et al (2010). Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies. Invest Radiol, 45, 715-24. https://doi.org/10.1097/RLI.0b013e3181e6f42f
  7. Chen Y, Wan Y, Wang Y, et al (2011). Anticancer efficacy enhancement and attenuation of side effects of doxorubicin with titanium dioxide nanoparticles. Int J Nanomedicine, 6, 2321.
  8. Cheng G, Zielonka J, Dranka BP, et al (2012). Mitochondriatargeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. Cancer Res, 72, 2634-44. https://doi.org/10.1158/0008-5472.CAN-11-3928
  9. Cho SH (2005). Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study. Phys Med Biol, 50, 163. https://doi.org/10.1088/0031-9155/50/15/N01
  10. Cobb JP, Hotchkiss RS, Karl IE, et al (1996). Mechanisms of cell injury and death. Br J Anaesth, 77, 3-10. https://doi.org/10.1093/bja/77.1.3
  11. Dwarkanath BS, Zolzer F, Chandana S, et al (2001). Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines. Int J Radiat Oncol Biol Phys, 50, 1051-61. https://doi.org/10.1016/S0360-3016(01)01534-6
  12. El-Kassas HY, El-Sheekh MM (2014). Cytotoxic activity of biosynthesized gold nanoparticles with an extract of the red seaweed Corallina officinalis on the MCF-7 human breast cancer cell line. Asian Pac J Cancer Prev, 15, 4311. https://doi.org/10.7314/APJCP.2014.15.10.4311
  13. Elstner E, Williamson EA, Zang C, et al (2002). Novel therapeutic approach: ligands for PPAR${\gamma}$ and retinoid receptors induce apoptosis in bcl-2-positive human breast cancer cells. Breast Cancer Res Treat, 74, 155-65. https://doi.org/10.1023/A:1016114026769
  14. Ghilotti M, Pierotti MA, Gariboldi M (2010). Molecular markers for prediction of risk of radiation-related injury to normal tissue. J Nucleic Acids Investig, 1, 11. https://doi.org/10.4081/jnai.2010.e11
  15. Hainfeld JF, Slatkin DN, Focella TM, et al (2014). Gold nanoparticles: a new X-ray contrast agent. Br J Radiol, 79, 248-53.
  16. Hou CH, Hou SM, Hsueh YS, et al (2009). The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy. Biomaterials, 30, 3956-60. https://doi.org/10.1016/j.biomaterials.2009.04.020
  17. Issels RD, Lindner LH, Verweij J, et al (2010). Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet Oncol, 11, 561-70. https://doi.org/10.1016/S1470-2045(10)70071-1
  18. Jain S, Coulter JA, Hounsell AR, et al (2011). Cell-specific radiosensitization by gold nanoparticles at megavoltage radiation energies. Int J Radiat Oncol Biol Phys, 79, 531-9. https://doi.org/10.1016/j.ijrobp.2010.08.044
  19. Jain S, Hirst DG, O'Sullivan JM (2014). Gold nanoparticles as novel agents for cancer therapy. Br J Radiol, 85, 101-13.
  20. Juzenas P, Chen W, Sun Y-P, et al (2008). Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer. Adv Drug Deliv Rev, 60, 1600-14. https://doi.org/10.1016/j.addr.2008.08.004
  21. Kaabinejadian S, Fouladdel SH, Ramezani M, et al (2008). p53 expression in MCF7, T47D and MDA-MB 468 breast cancer cell lines treated with adriamycin using RT-PCR and immunocytochemistry. J Biol Sci, 8, 380-5. https://doi.org/10.3923/jbs.2008.380.385
  22. Kong Q, Lillehei KO (1998). Antioxidant inhibitors for cancer therapy. Med Hypotheses, 51, 405-9. https://doi.org/10.1016/S0306-9877(98)90036-6
  23. Loh SY, Chew SL (2011). Awareness and practice of breast self examination among Malaysian women with breast cancer. Asian Pac J Cancer Prev, 12,199-202.
  24. Lu J, Ma S, Sun J, et al (2009). Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging. Biomaterials, 30, 2919-28. https://doi.org/10.1016/j.biomaterials.2009.02.001
  25. McPherson K, Steel C, Dixon JM (2000). ABC of breast diseases: breast cancer-epidemiology, risk factors, and genetics. BMJ, 321, 624. https://doi.org/10.1136/bmj.321.7261.624
  26. Mentis A-FA, Saha P, Das S, et al (2010). Metabolism and cancer: an up-to-date review of a mutual connection. Asian Pac J Cancer Prev, 11, 1437-44.
  27. Mitra S, Gaur U, Ghosh PC, et al (2001). Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. J Control Release, 74, 317-23. https://doi.org/10.1016/S0168-3659(01)00342-X
  28. Nahrendorf M, Zhang H, Hembrador S, et al (2008). Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation, 117, 379-87. https://doi.org/10.1161/CIRCULATIONAHA.107.741181
  29. Nogueira DR, Rolim CMB, Farooqi AA (2014). Nanoparticle induced oxidative stress in cancer cells: adding new pieces to an incomplete jigsaw puzzle. Asian Pac J Cancer Prev, 15, 4739-43. https://doi.org/10.7314/APJCP.2014.15.12.4739
  30. Quiles JL, Huertas JR, Battino M, et al (2002). Antioxidant nutrients and adriamycin toxicity. Toxicol, 180, 79-95. https://doi.org/10.1016/S0300-483X(02)00383-9
  31. Schwarz SB, Schaffer PM, Kulka U, et al (2008). The effect of radio-adaptive doses on HT29 and GM637 cells. Radiat Oncol, 3, 1-6. https://doi.org/10.1186/1748-717X-3-1
  32. Selim ME, Hendi AA (2012). Gold nanoparticles induce apoptosis in MCF-7 human breast cancer cells. Asian Pac J Cancer Prev, 13, 1617-20. https://doi.org/10.7314/APJCP.2012.13.4.1617
  33. Takanashi S, Bachur NR (1976). Adriamycin metabolism in man. Evidence from urinary metabolites. Drug Metab Dispos, 4, 79-87.
  34. Van der Zee J, Gonzalez D, van Rhoon GC, et al (2000). Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Lancet, 355, 1119-25. https://doi.org/10.1016/S0140-6736(00)02059-6
  35. Verma NK, Crosbie-Staunton K, Satti A, et al (2013). Magnetic core-shell nanoparticles for drug delivery by nebulization. J Nanobiotechnol, 11.
  36. Vernon CC, Hand JW, Field SB, et al (1996). Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: Results from five randomized controlled trials. Int J Radiat Oncol Biol Phys, 35, 731-44. https://doi.org/10.1016/0360-3016(96)00154-X
  37. Warburg O (1956). The metabolism of tumors, Science, 123, 309-14. https://doi.org/10.1126/science.123.3191.309
  38. Wust P, Hildebrandt B, Sreenivasa G, et al (2002). Hyperthermia in combined treatment of cancer. Lancet Oncol, 3, 487-97. https://doi.org/10.1016/S1470-2045(02)00818-5
  39. Yadav D, Anwar MF, Garg V, et al (2014). Development of polymeric nanopaclitaxel and comparison with free paclitaxel for effects on cell proliferation of MCF-7 and B16F0 carcinoma cells. Asian Pac J Cancer Prev, 15, 2335-40. https://doi.org/10.7314/APJCP.2014.15.5.2335
  40. Yang WT, Le-Petross HT, Macapinlac H, et al (2008). Inflammatory breast cancer: PET/CT, MRI, mammography, and sonography findings. Breast Cancer Res Treat, 109, 417-26. https://doi.org/10.1007/s10549-007-9671-z
  41. Yen SK, Padmanabhan P, Selvan ST (2013). Multifunctional iron oxide nanoparticles for diagnostics, therapy and macromolecule delivery. Theranostics, 3, 986. https://doi.org/10.7150/thno.4827
  42. Yin H-T, Zhang DG, Wu XL, et al (2013). In vivo evaluation of curcumin-loaded nanoparticles in a A549 xenograft mice model. Asian Pac J Cancer Prev, 14, 409-12. https://doi.org/10.7314/APJCP.2013.14.1.409
  43. Zhang X, Xing JZ, Chen J, et al (2008). Enhanced radiation sensitivity in prostate cancer by gold-nanoparticles. Clin Invest Med, 31, 160-7.
  44. Zheng Y, Hunting DJ, Ayotte P, et al (2009). Radiosensitization of DNA by gold nanoparticles irradiated with high-energy electrons. Radiat Res, 169, 19-27.

Cited by

  1. BIAN N-Heterocyclic Gold Carbene Complexes induced cytotoxicity in human cancer cells via upregulating oxidative stress vol.16, pp.16, 2015, https://doi.org/10.7314/APJCP.2015.16.16.7003