Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Young Women with Breast Cancer in the United States and South Korea: Comparison of Demographics, Pathology and Management

  • Son, Byung Ho (Department of Breast and Endocrine Surgery, Asan Medical Center) ;
  • Dominici, Laura S (Department of Surgery, Brigham and Women's Hospital) ;
  • Aydogan, Fatih (Department of Surgery, Brigham and Women's Hospital) ;
  • Shulman, Lawrence N (Department of Medical Oncology, Dana Farber Cancer Institute) ;
  • Ahn, Sei Hyn (Department of Breast and Endocrine Surgery, Asan Medical Center) ;
  • Cho, Ja Young (Department of Breast and Endocrine Surgery, Asan Medical Center) ;
  • Coopey, Suzanne B (Department of Surgery, Massachusetts General Hospital) ;
  • Kim, Sung Bae (Department of Medical Oncology, Asan Medical Center) ;
  • Min, H Elise (Department of Surgery, Brigham and Women's Hospital) ;
  • Valero, Monica (Department of Surgery, Brigham and Women's Hospital) ;
  • Wang, Jiping (Department of Surgery, Brigham and Women's Hospital) ;
  • Caragacianu, Diana (Department of Surgery, Brigham and Women's Hospital) ;
  • Gong, Gyung-yub (Department of Pathology, Asan Medical Center) ;
  • Hevelone, Nathanael D (Department of Surgery, Brigham and Women's Hospital) ;
  • Baek, Seunghee (Department of Clinical Epidemiology and Biostatistics, Asan Medical Center) ;
  • Golshan, Mehra (Department of Surgery, Brigham and Women's Hospital)
  • Published : 2015.04.03
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Abstract

Background: Breast cancer diagnosed in young women may be more aggressive, with higher rates of local and distant recurrence compared to the disease in older women. Epidemiologic evidence suggests that Korean women have a lower incidence of breast cancer than women in the United States, but that they present at a younger age than their American counterparts. We sought to compare risk factors and management of young women with breast cancer in Boston, Massachusetts (US) with those in Seoul, South Korea (KR). Materials and Methods: A retrospective review was performed of consecutive patients less than 35 years old with a diagnosis of breast cancer at academic cancer centers in the US and KR from 2000-2005. Patient data were obtained by chart review. Demographic, tumor and treatment characteristics were compared utilizing Pearson's chisquare or Wilcoxon rank-sum tests where appropriate. All differences were assessed as significant at the 0.05 level. Results: 205 patients from the US and 309 from KR were analyzed. Patients in US were more likely to have hormone receptor positive breast cancer, while patients in KR had a higher rate of triple negative lesions. Patients in US had a higher mean body mass index and more often reported use of birth control pills, while those in the KR were less likely to have a sentinel node procedure performed or to receive post mastectomy radiation. Conclusions: Patients under 35 diagnosed with breast cancer in the US and KR differ with respect to demographics, tumor characteristics and management. Although rates of breast conservation and mastectomy were similar, US patients were more likely to receive post mastectomy radiation. The lower use of sentinel node biopsy is explained by the later adoption of the technique in KR. Further evaluation is necessary to evaluate recurrence rates and survival in the setting of differing disease subtypes in these patients.

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References

  1. Agarwal G, Pradeep PV, Aggarwal V, et al (2007). Spectrum of Breast Cancer in Asian Women. World J Surg, 31, 1031-40. https://doi.org/10.1007/s00268-005-0585-9
  2. Anders CK, Hsu DS, Broadwater G, et al (2008). Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol, 26, 3324-30. https://doi.org/10.1200/JCO.2007.14.2471
  3. Cheraghi Z, Poorolajal J, Hashem T, et al (2012). Effect of body mass index on breast cancer during premenopausal and postmenopausal periods: a meta-analysis. PLoS One, 7, 51446. https://doi.org/10.1371/journal.pone.0051446
  4. Choi DH, Lee MH, Bale AE, et al (2004). Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients. J Clin Oncol, 22, 1638-45. https://doi.org/10.1200/JCO.2004.04.179
  5. Choi DH, Shin DB, Lee MH, et al (2003). A comparison of five immunohistochemical biomarkers and HER-2/neu gene amplification by fluorescence in situ hybridization in white and korean patients with early-onset breast carcinoma. Cancer, 98, 1587-95. https://doi.org/10.1002/cncr.11703
  6. Choi KS, Lee S, Park EC, et al (2010) Comparison of breast cancer screening rates between Korean women in America versus Korea. J Womens Health (Larchmt). 19, 1089-96. https://doi.org/10.1089/jwh.2009.1584
  7. Chuang E, Paul C, Flam A, et al (2012). Breast cancer subtypes in Asian-Americans differ according to Asian ethnic group. J Immigr Minor Health, 14, 754-8. https://doi.org/10.1007/s10903-012-9577-7
  8. Collaborative Group on Hormonal Factors in Breast Cancer, (1996). Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Lancet, 347, 1713-27. https://doi.org/10.1016/S0140-6736(96)90806-5
  9. Colleoni M, Rotmensz N, Robertson C, et al (2002). Very young women (<35 years) with operable breast cancer: features of disease at presentation. Ann Oncol, 13, 273-9.
  10. Deapen D, Liu L, Perkins C, et al (2002). Rapidly rising breast cancer incidence rates among Asian-American women. Int J Cancer, 99, 747-50. https://doi.org/10.1002/ijc.10415
  11. de la Rochefordiere A, Asselain B, Campana F, et al (1993) Age as prognostic factor in premenopausal breast carcinoma. Lancet, 341, 1039-43. https://doi.org/10.1016/0140-6736(93)92407-K
  12. DeSantis CE, Lin CC, Mariotto AB, et al (2014). Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin, 64, 252-71. https://doi.org/10.3322/caac.21235
  13. Dorjgochoo T, Shu XO, Li HL, et al (2006). Use of oral contraceptives, intrauterine devices and tubal sterilization and cancer risk in a large prospective study, from 1996 to 2006. Int J Cancer, 124, 2442-9.
  14. Foulkes WD, Smith IE, Reis-Filho JS, (2010). Triple-negative breast cancer. N Engl J Med, 363, 1938-48. https://doi.org/10.1056/NEJMra1001389
  15. Gajdos C, Tartter PI, Bleiweiss IJ, et al (2000). Stage 0 to Stage III Breast Cancer in Young Women. J Am Coll Surg, 190, 523-9. https://doi.org/10.1016/S1072-7515(00)00257-X
  16. Gaudineau A, Ehlinger V, Vayssiere C, et al (2010). Factors associated with early menarche: results from the French Health Behaviour in School-aged Children (HBSC) study. BMC Public Health, 30, 175.
  17. Goksu SS, Tastekin D, Arslan D, et al (2014). Clinicopathologic features and molecular subtypes of breast cancer in young women ($age{\leq}35$). Asian Pac J Cancer Prev, 15, 6665-8. https://doi.org/10.7314/APJCP.2014.15.16.6665
  18. Han JG, Jiang YD, Zhang CH, et al (2011). Clinicopathologic characteristics and prognosis of young patients with breast cancer. Breast, 20, 370-2. https://doi.org/10.1016/j.breast.2011.02.011
  19. Han W, Kang SY; Korean Breast Cancer Society (2010). Relationship between age at diagnosis and outcome of premenopausal breast cancer: age less than 35 years is a reasonable cut-off for defining young age-onset breast cancer. Breast Cancer Res Treat, 119, 193-200. https://doi.org/10.1007/s10549-009-0388-z
  20. Han SA, Park SK, Ahn SH, et al (2011). The Korean Hereditary Breast Cancer (KOHBRA) study: protocols and interim report. Clin Oncol (R Coll Radiol), 23, 434-41. https://doi.org/10.1016/j.clon.2010.11.007
  21. Huang Z, Hankinson SE, Colditz GA, et al (1997). Dual effects of weight and weight gain on breast cancer risk. JAMA, 278, 1407-11. https://doi.org/10.1001/jama.1997.03550170037029
  22. Jung D, Lee SM (2009). BMI and breast cancer in Korean Women: a meta-analysis. Asian Nurs Res, 3, 31-40. https://doi.org/10.1016/S1976-1317(09)60014-1
  23. Jung KW, Won YJ, Kong HJ, et al (2013). Prediction of cancer incidence and mortality in Korea, 2013. Cancer Res Treat, 45, 15-21. https://doi.org/10.4143/crt.2013.45.1.15
  24. Kahlenborn C, Modugno F, Potter DM, et al (2006). Oral contraceptive use as a risk factor for premenopausal breast cancer: a meta-analysis. Mayo Clin Proc, 81, 1290-302. https://doi.org/10.4065/81.10.1290
  25. Kim IK, Park S, Hwang H, et al (2011). Clinical significance of age at the time of diagnosis among young breast cancer patients. J Breast Cancer, 14, 314-21. https://doi.org/10.4048/jbc.2011.14.4.314
  26. Kim Z, Min SY, Yoon CS, et al (2014). The basic facts of korean breast cancer in 2011: results of a nationwide survey and breast cancer registry database. J Breast Cancer, 17, 99-106. https://doi.org/10.4048/jbc.2014.17.2.99
  27. Ko, BS, Noh WC, Kang SS, et al (2012). Changing patterns in the clinical characteristics of Korean breast cancer from 1996-2010 using an online nationwide breast cancer database. J Breast Cancer, 15, 393-400. https://doi.org/10.4048/jbc.2012.15.4.393
  28. Lamartiniere CA, Cotroneo MS, Fritz WA, et al (2002). Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate. J Nutr, 132, 552-558.
  29. Leong SP, Shen ZZ, Liu TJ, et al (2010). Is breast cancer the same disease in asian and western countries? World J Surg, 34, 2308-24. https://doi.org/10.1007/s00268-010-0683-1
  30. Lim SE, Back M, Quek E, (2007). Clinical observations from a breast cancer registry in asian women.World J Surg, 31, 1387-92. https://doi.org/10.1007/s00268-007-9086-3
  31. Liukkonen S, Leidenius M, Saarto T, et al (2011). Breast cancer in very young women. Eur J Surg Oncol, 37, 1030-7. https://doi.org/10.1016/j.ejso.2011.08.133
  32. Marchbanks PA, McDonald JA, Wilson HG, et al (2002). Oral contraceptives and the risk of breast cancer. N Engl J Med, 346, 2025-32. https://doi.org/10.1056/NEJMoa013202
  33. Nelson HD, Zakher B, Cantor A, et al (2012). Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis. Ann Intern Med, 156, 635-48. https://doi.org/10.7326/0003-4819-156-9-201205010-00006
  34. Reeves GK, Pirie K, Beral V, et al (2007). Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ, 335, 1134. https://doi.org/10.1136/bmj.39367.495995.AE
  35. Rosenberg SM, Sepucha K, Ruddy KJ. Choosing mastectomy over lumpectomy: Factors associated with surgical decisions in young women with breast cancer. Presented ASCO 2013, Chicago, IL.
  36. Rummel S, Varner E, Shriver CD, et al (2013). Evaluation of BRCA1 mutations in an unselected patient population with triple-negative breast cancer. Breast Cancer Res Treat, 137, 119-25. https://doi.org/10.1007/s10549-012-2348-2
  37. Son BH, Ahn SH, Kim SW, et al (2012). Prevalence of BRCA1 and BRCA2 mutations in non-familial breast cancer patients with high risks in Korea: the Korean Hereditary Breast Cancer (KOHBRA) Study. Breast Cancer Res Treat, 133, 1143-52. https://doi.org/10.1007/s10549-012-2001-0
  38. Son BH, Kwak BS, Kim JK, et al (2006). Changing patterns in the clinical characteristics of korean patients with breast cancer during the last 15 years. Arch Surg, 141, 155-60. https://doi.org/10.1001/archsurg.141.2.155
  39. Suh M, Choi KS, Lee YY, et al (2013). Trends in cancer screening rates among Korean men and women: results from the Korean national cancer screening survey, 2004-2012. Cancer Res Treat, 45, 86-94. https://doi.org/10.4143/crt.2013.45.2.86
  40. Toi M, Ohashi Y, Seow A, et al (2010). The Breast Cancer Working Group presentation was divided into three sections: the epidemiology, pathology and treatment of breast cancer. Jpn J Clin Oncol, 40, 13-8. https://doi.org/10.1093/jjco/hyq122
  41. van den Brandt PA, Spiegelman D, Yaun SS, et al (2000). Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol, 152, 514-27. https://doi.org/10.1093/aje/152.6.514
  42. Wei XQ, Li X, Xin XJ, et al (2013). Clinical features and survival analysis of very young (age<35) breast cancer patients. Asian Pac J Cancer Prev, 14, 5949-52. https://doi.org/10.7314/APJCP.2013.14.10.5949
  43. Yang Q, Khoury MJ, Rodriguez C, et al (1998). Family history score as a predictor of breast cancer mortality: prospective data from the cancer prevention study II, United States, 1982-1991. Am J Epidemiol, 147, 652-9. https://doi.org/10.1093/oxfordjournals.aje.a009506
  44. Zhu H, Lei X, Feng J, Wang Y, (2012). Oral contraceptive use and risk of breast cancer: a meta-analysis of prospective cohort studies. Eur J Contracept Reprod Health Care, 17, 402-14. https://doi.org/10.3109/13625187.2012.715357

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