Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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RASSF1A Gene Methylation is Associated with Nasopharyngeal Carcinoma Risk in Chinese

  • Wu, Kun (Medical Faculty, Kunming University of Science and Technology) ;
  • Xu, Xiao-Ning (Clinical psychology department, the First People's Hospital of Yunnan Province, Panlong Campus) ;
  • Chen, Yu (Medical Faculty, Kunming University of Science and Technology) ;
  • Pu, Xiao-Lin (Medical Faculty, Kunming University of Science and Technology) ;
  • Wang, Bo-Yuan (Digestive system department, the First People's Hospital of Yunnan Province, Panlong Campus) ;
  • Tang, Xiao-Dan (Medical Faculty, Kunming University of Science and Technology)
  • Published : 2015.04.03
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Abstract

In order to explore the association between RASSF1A methylation and nasopharyngeal carcinoma (NPC) risk of Chinese, we carried out a meta-analysis with searches of PubMed, Web of Science, ProQest and Medline databases. Ultimately, 14 articles were identified and analysised using R Software (R version 3.1.2) including meta packages. Overall, we found a significant relationship between RASSF1A methylation and NPC risk (OR 30.7; 95 % CI, 16.71~56.23; z=11.0591; p<0.0001) in a fixed effects model and (OR 32.1; 95% CI, 14.27~72.01; z=8.3984; p<0.0001) in a random effects model pooled. In tissue and NP brushings groups, similar results were found. Hence, our study identified a strong association between RASSF1A methylation and NPC and highlighted a promising potential for RASSF1A methylation in NPC risk prediction of Chinese.

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References

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