DOI QR코드

DOI QR Code

Imaging Anatomy of Waldeyer's Ring and PET/CT and MRI Findings of Oropharyngeal Non-Hodgkin's Lymphoma

  • Zhang, Chun-Xing (Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital) ;
  • Liang, Long (Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital) ;
  • Zhang, Bin (Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital) ;
  • Chen, Wen-Bo (Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital) ;
  • Liu, Hong-Jun (Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital) ;
  • Liu, Chun-Ling (Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital) ;
  • Zhou, Zheng-Gen (Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital) ;
  • Liang, Chang-Hong (Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital) ;
  • Zhang, Shui-Xing (Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital)
  • Published : 2015.04.29

Abstract

Background: This study was conducted to analyze positron emission tomography (PET) / computed tomography (CT) and magnetic resonance imaging (MRI) performance with oropharyngeal non-Hodgkin's lymphoma (ONHL).Materials and Methods: The complete image data of 30 ONHL cases were analyzed, all patients were performed PET / CT and MRI examination before the treatment, with the time interval of these two inspections not exceeding 14 days. The distribution, morphology, MRI signal characteristics, enhancement feature, standardized uptake value (SUV) max value and lymph node metastasis way of the lesions were analyzed. Results: Among the 30 cases, 23 cases were derived from the B-cell (76.7%), 5 cases were derived from the peripheral T cells (16.7%) and 2 cases were derived from the NK/T cells (6.7%). 19 cases exhibited the palatine tonsil involvement (63.3%). As for the lesion appearance, 10 cases appeared as mass, 8 cases were the diffused type and 12 cases were the mixed type. 25 cases exhibited the SUVmax value of PET / CT primary lesions as 11 or more (83.3%). MRI showed that all patients exhibited various degrees of parapharyngeal side-compressed narrowing, but MRI still exhibited the high-signal fat, and the oropharyngeal mucosa was intact. 25 cases were associated with the neck lymph node metastasis, among who 22 cases had no necrosis in the metastatic lymph nodes, while the rest 3 cases exhibited the central necrosis in the metastatic lymph nodes. Conclusions: PET / CT and MRI have important value in diagnosing and determining the lesion extent of ONHL.

Keywords

References

  1. Bregni R, Nuyens M, Vassallo J, et al (2012). Marginal zone lymphoma of mucosa-associated lymphoid tissue with prominent plasma cell differentiation affecting the palatine tonsil: histopathological and immunohistochemical analysis. Oral Surg Oral Med Oral Pathol Oral Radiol, 113, 526-32. https://doi.org/10.1016/j.oooo.2011.11.002
  2. Chiewvit S, Thephamongkhol K, Ubolnuch K, et al (2014). Comparison of 18F-FDG Pet/CT and CT: diagnosis performance in lymphoma patient after treatment. J Med Assoc Thai, 97, 85-94.
  3. de Leval L, Bonnet C, Copie-Bergman C, et al (2012). Diffuse large B-cell lymphoma of Waldeyer's ring has distinct clinicopathologic features: a GELA study. Ann Oncol, 23, 3143-51. https://doi.org/10.1093/annonc/mds150
  4. De Paepe K, Bevernage C, De Keyzer F, et al (2013). Wholebody diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study. Cancer Imaging, 13, 53-62. https://doi.org/10.1102/1470-7330.2013.0006
  5. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M (2010). Head and neck non-Hodgkin's lymphoma: a 20-year demographic study of 381 cases. Int J Oral Maxillofac Surg, 39, 869-72. https://doi.org/10.1016/j.ijom.2010.03.029
  6. Hosokai R, Imai C, Takachi T, et al (2011). Reactive tonsillar enlargement with strong 18F-FDG uptake after chemotherapy for tonsillar diffuse large B-cell lymphoma. J Pediatr Hematol Oncol, 33, 87-88.
  7. Illidge T, Specht L, Yahalom J, et al (2014). Modern radiation therapy for nodal non-Hodgkin lymphoma-target definition and dose guidelines from the International Lymphoma Radiation Oncology Group. Int J Radiat Oncol Biol Phys, 89, 49-58. https://doi.org/10.1016/j.ijrobp.2014.01.006
  8. Ito K, Smith BR, Parashurama N, et al (2012). Unexpected dissemination patterns in lymphoma progression revealed by serial imaging within a murine lymph node. Cancer Res, 72, 6111-8. https://doi.org/10.1158/0008-5472.CAN-12-2579
  9. Juweid ME, Cheson BD (2005). Role of positron emission tomography in lymphoma. J Clin Oncol, 23, 4577-80. https://doi.org/10.1200/JCO.2005.01.904
  10. Kato H, Kanematsu M, Kawaguchi S, et al (2013). Evaluation of imaging findings differentiating extranodal non-Hodgkin's lymphoma from squamous cell carcinoma in naso- and oropharynx. Clin Imaging, 37, 657-63. https://doi.org/10.1016/j.clinimag.2012.11.007
  11. Kostakoglu L, Cheson BD (2014). Current role of FDG PET/CT in lymphoma. Eur J Nucl Med Mol Imaging, 41, 1004-27. https://doi.org/10.1007/s00259-013-2686-2
  12. Loggers ET, Fishman PA, Peterson D, et al (2014). Advanced imaging among health maintenance organization enrollees with cancer. J Oncol Pract, 10, 231-8. https://doi.org/10.1200/JOP.2013.001258
  13. Matsuzaki H, Hara M, Yanagi Y, et al (2012). Magnetic resonance imaging (MRI) and dynamic MRI evaluation of extranodal non-Hodgkin lymphoma in oral and maxillofacial regions. Oral Surg Oral Med Oral Pathol Oral Radiol, 113, 126-33. https://doi.org/10.1016/j.tripleo.2011.07.038
  14. Qiu L, Chen Y, Wu J (2013). The role of 18F-FDG PET and 18F-FDG PET/CT in the evaluation of pediatric Hodgkin's lymphoma and non-Hodgkin's lymphoma. Hell J Nucl Med, 16, 230-6.
  15. Saito A, Takashima S, Takayama F, et al (2001). Spontaneous extensive necrosis in non-Hodgkin lymphoma: prevalence and clinical significance. J Comput Assist Tomogr, 25, 482-6. https://doi.org/10.1097/00004728-200105000-00024
  16. Salplahta D, Comănescu MV, Anghelina F, et al (2012). Non-Hodgkin lymphomas of Waldeyer's ring. Rom J Morphol Embryol, 53, 1057-60.
  17. Schoder H, Noy A, Gonen M, et al (2005). Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin's lymphoma. J Clin Oncol, 23, 4643-51. https://doi.org/10.1200/JCO.2005.12.072
  18. Wolach O, Bernstine H, Edel Y, et al (2014). Limited positron emission tomography-computed tomography for restaging of lymphoma: a strategy for reducing radiation exposure among patients with early-stage curable lymphoma. Acta Haematol, 131, 239-44. https://doi.org/10.1159/000354842
  19. Yahalom J (2014). Radiotherapy of follicular lymphoma: updated role and new rules. Curr Treat Options Oncol, 15, 262-8. https://doi.org/10.1007/s11864-014-0286-4
  20. Zanoni L, Cerci JJ, Fanti S (2011). Use of PET/CT to evaluate response to therapy in lymphoma. Q J Nucl Med Mol Imaging, 55, 633-47.