Asian Pacific Journal of Cancer Prevention

  • 제16권8호
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  • Pages.3117-3120
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  • 2015
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Association Study of Single-Nucleotide Polymorphisms of STAT2/STAT3/IFN-γ Genes in Cervical Cancer in Southern Chinese Han Women

  • Yuan, Yuan (Department of Immunology, Basic Medical College, Central South University) ;
  • Fan, Jie-Lin (Department of Gynecologic Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine/Hunan Cancer Hospital, Central South University) ;
  • Yao, Fang-Ling (Department of Immunology, Basic Medical College, Central South University) ;
  • Wang, Kang-Tao (Department of Immunology, Basic Medical College, Central South University) ;
  • Yu, Ying (Department of Immunology, Basic Medical College, Central South University) ;
  • Carlson, Jennifer (Division of Laboratory Genetics, Mayo Clinic) ;
  • Li, Ming (Department of Immunology, Basic Medical College, Central South University)
  • 발행 : 2015.04.29
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초록

Objective: Interferon-${\gamma}$ (IFN-${\gamma}$) and signal transducers and activators of transcription (STATs) each play an important role in carcinogenesis associated with viral infection. Cervical cancer is almost invariably associated with infection by human papillomavirus (HPV), and previous studies suggested that dysregulation of the signal pathway involved in IFN-${\gamma}$ and STATs is associated. Our objective was to evaluate the association of SNPs in STAT2, STAT3, and IFN-${\gamma}$ with cervical cancer susceptibility in Chinese Han women in Hunan province. Materials and Methods: Genomic DNA was extracted from peripheral blood samples of 234 cervical cancer patients and 216 healthy female controls. STAT2 and STAT3 genotyping was performed using polymerase chain reaction-restriction enzyme (PCR-RE) analysis. IFN-${\gamma}$ genotyping was detected by PCR-amplification of specific allele (PASA). Results: For STAT2 rs2066807 polymorphisms, there was no significant difference of genotype distribution (P=0.827) and allele frequencies (P=0.830, OR=1.09, 95% CI: 0.51-2.31) between cases and controls. For STAT3 rs957970 polymorphisms, there was no significant difference of genotype distribution (P=0.455) and allele frequencies (P=0.560, OR=0.92, 95% CI: 0.71-1.20) between cases and controls. For IFN-${\gamma}$ +874A/T polymorphisms, there was no significant difference of genotype distribution (P=0.652) and allele frequencies (P=0.527, OR=1.12, 95% CI: 0.79-1.59) between cases and controls. Conclusion: These results suggest that polymorphisms in STAT2, STAT3 and IFN-${\gamma}$ genes are not likely to be strong predictors of cervical cancer in Han women in southern China.

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참고문헌

  1. Gamero AM, Young MR, Mentor-Marcel R, et al (2010). STAT2 contributes to promotion of colorectal and skin carcinogenesis. Cancer Prev Res, 3, 495-504. https://doi.org/10.1158/1940-6207.CAPR-09-0105
  2. Gangwar R, Pandey S, Mittal RD (2009). Association of interferon-$\gamma$ +874A polymorphism with the risk of developing cervical cancer in north-Indian population. BJOG, 116, 1671-7. https://doi.org/10.1111/j.1471-0528.2009.02307.x
  3. Ge YZ, Wang YD, Xu Z, et al (2014). Lack of association between interferon gamma +874 T/A polymorphism and cancer risk: an updated meta-analysis. Tumor Biol, 35, 6405-14. https://doi.org/10.1007/s13277-014-1861-9
  4. George R. Stark, James E. et al (2012). The JAK-STAT pathway at twenty. Immunity, 36, 503-14. https://doi.org/10.1016/j.immuni.2012.03.013
  5. Govan VA, Carrara HR, Sachs JA, et al (2003). Ethnic differences in allelic distribution of IFN-g in South African women but no link with cervical cancer. J Carcinog, 2, 3. https://doi.org/10.1186/1477-3163-2-3
  6. Liang Z, Gao LH, Cao LJ, et al (2012). Detection of STAT2 in early stage of cervical premalignancy and in cervical cancer. Asian Pac J Trop Med, 5, 738-42. https://doi.org/10.1016/S1995-7645(12)60117-5
  7. Pandurangan AK, Esa NM (2014). Signal transducer and activator of transcription 3 - a promising target in colitisassociated cancer. Asian Pac J Cancer Prev, 15, 551-60. https://doi.org/10.7314/APJCP.2014.15.2.551
  8. Pravica V, Perrey C, Stevens A, et al (2000). A single nucleotide polymorphism in the first intron of the human IFNgamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol, 61, 863-6. https://doi.org/10.1016/S0198-8859(00)00167-1
  9. Qing Y, Stark GR (2004). Alternative activation of STAT1 and STAT3 in response to interferon-$\gamma$. J Biol Chem, 279, 41679-85. https://doi.org/10.1074/jbc.M406413200
  10. Rajbhandary S, Zhao MF, Zhao N, et al (2013). Multiple cytotoxic factors involved in IL-21 enhanced antitumor function of CIK cells signaled through STAT-3 and STAT5b pathways. Asian Pac J Cancer Prev, 14, 5825-31. https://doi.org/10.7314/APJCP.2013.14.10.5825
  11. Stone SC, Rossetti RA, Bolpetti A, et al (2014). HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells. J Leukoc Biol, 96, 619-31. https://doi.org/10.1189/jlb.3A0513-282R
  12. Sun Y, Lu Y, Pen Q, et al (2015). Interferon gamma +874 T/A polymorphism increases the risk of cervical cancer: evidence from a meta-analysis. Tumour Biol, [Epub ahead of print].
  13. Van Bogaert L (2013). Are the currently existing anti-human papilloma virus vaccines appropriate for the developing world? Ann Med Health Sci Res, 3, 306-12. https://doi.org/10.4103/2141-9248.117924
  14. Wang K, Zhou B, Zhang J, et al (2011). Association of signal transducer and activator of transcription 3 gene polymorphisms with cervical cancer in Chinese women. DNA Cell Biol, 30, 931-6. https://doi.org/10.1089/dna.2010.1179
  15. Wang Q, Zhang C, Walayat S, et al (2011). Association between cytokine gene polymorphisms and cervical cancer in a Chinese population. Eur J Obstet Gynecol Reprod Biol, 158, 330-3. https://doi.org/10.1016/j.ejogrb.2011.05.019
  16. Xiong A, Yang Z, Shen Y, et al (2014). Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention. Cancers (Basel), 6, 926-57. https://doi.org/10.3390/cancers6020926
  17. Zhang P, Li H, Yang B, et al (2014). Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling incervical cancer cells. Genes Cancer, 5, 154-64.
  18. Zimmermann A, Trilling M, Wagner M, et al (2005). A cytomegaloviral protein reveals a dual role for STAT2 in IFN-$\gamma$ signaling and antiviral responses. J Exp Med, 201, 1543-53. https://doi.org/10.1084/jem.20041401

피인용 문헌

  1. Note of clarification of data in the paper entitled “Interferon gamma +874 T/A polymorphism increases the risk of cervical cancer: evidence from a meta-analysis” vol.39, pp.4, 2017, https://doi.org/10.1177/1010428317694564