Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effect of Intravenous Administration of Tramadol on the Minimum Alveolar Concentration of Isoflurane in Dogs

개에서 트라마돌의 정맥투여가 아이소플루란의 최소폐포농도에 미치는 영향

  • Seok, Seong-Hoon (Laboratory of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Park, Se-Jin (Laboratory of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Seung-Yong (Laboratory of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Jin, So-Young (Laboratory of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kim, Young-Ki (Haeundae Animal Medical Center) ;
  • Hwang, Jae-Min (Laboratory of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University) ;
  • Lee, Hee-Chun (Laboratory of Veterinary Medical Imaging, College of Veterinary Medicine, Gyeongsang National University) ;
  • Yeon, Seong-Chan (Laboratory of Veterinary Surgery and Behavior, College of Veterinary Medicine, Gyeongsang National University)
  • 석성훈 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 박세진 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 이승용 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 진소영 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 김영기 (해운대 동물 메디컬 센터) ;
  • 황재민 (경상대학교 수의과대학 수의외과.행동학 연구실) ;
  • 이희천 (경상대학교 수의과대학 수의영상의학 실험실) ;
  • 연성찬 (경상대학교 수의과대학 수의외과.행동학 연구실)
  • Accepted : 2015.06.26
  • Published : 2015.08.31
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Abstract

This study was aimed to evaluate the effects of tramadol hydrochloride on the minimum alveolar concentration of isoflurane ($MAC_{ISO}$) in dogs. Six healthy, female German shepherd dogs (aged 1-2 years) were used in this study. Anesthesia was induced by mask induction and maintained with isoflurane in oxygen. Mechanical ventilation maintained the end-tidal $CO_2$ partial pressure ($P_{ET}CO_2$) from 35 to 45 mmHg throughout the study. A baseline $MAC_{ISO}$ ($MAC_{ISO}B$) was determined starting 45 minutes after induction of anesthesia by clamping a pedal digit until gross purposeful movement was detected. After $MAC_{ISO}B$ determination, dogs received a tramadol loading dose of 3 mg/kg followed by a continuous rate infusion (CRI) of 2.6 mg/kg/h. The determination of $MAC_{ISO}$ after administration of tramadol ($MAC_{ISO}T$) began 20 min after the start of the CRI. Arterial blood pressure and heart rate were recorded continuously and arterial blood samples for blood gas analysis were collected at the end of the equilibration period. Mean ${\pm}$ SD values for the $MAC_{ISO}B$ and $MAC_{ISO}T$ were $1.33{\pm}0.04%$ and $1.23{\pm}0.04%$, respectively. The $MAC_{ISO}B$ decreased significantly by $7.5{\pm}0.2%$ (P < 0.05) after administration of tramadol. The mean heart rate and arterial blood pressure of six dogs were not changed significantly after tramadol administration. The blood gas levels remained constant during the study. In conclusion, tramadol could significantly reduce $MAC_{ISO}$ without depression of cardiorespiratory function. Thus, the use of tramadol on inhalation anesthesia with isoflurane in dogs can improve the stability of anesthesia and the quality of recovery.

본 연구는 개에서 트라마돌의 정맥투여가 아이소플루란의 최소폐포농도 ($MAC_{ISO}$)에 미치는 영향을 평가하기 위하여 수행되었다. 6마리의 암컷 저먼셰퍼드견이 본 실험에 사용되었다. 실험견의 마취유도는 안면마스크를 이용하여 시행되었으며 실험하는 동안 기계적 환기장치를 이용하여 호기말 이산화탄소 분압 ($P_{ET}CO_2$)을 35-45 mmHg로 유지하였다. 개에서 마취유도 후 45분이 경과한 다음 gross purposeful movement가 감지 될 때까지 후지 발가락을 클램핑하는 방법을 사용하여 baseline $MAC_{ISO}$ ($MAC_{ISO}B$) 측정을 시작하였다. $MAC_{ISO}B$가 결정된 후, 트라마돌 3 mg/kg을 투여하였고 뒤이어 2.6 mg/kg/h으로 지속점적투여 (CRI)를 실시하였다. CRI 시작 후 20분이 경과한 다음, 트라마돌 투여 후 $MAC_{ISO}$값 ($MAC_{ISO}T$) 측정을 시작하였다. 동맥혈압과 심박수는 지속적으로 기록하였고 $MAC_{ISO}B$와 $MAC_{ISO}T$의 결정 후 각각 20분간 평형기간이 경과한 다음 동맥혈가스분석을 실시하였다. $MAC_{ISO}B$와 $MAC_{ISO}T$는 각각 $1.33{\pm}0.04%$와 $1.23{\pm}0.04%$로 측정되었고 $MAC_{ISO}B$는 트라마돌 투여 후 $7.5{\pm}0.2%$의 유의적인 (P < 0.05) 감소효과를 나타냈다. 트라마돌 투여 후 심박수와 동맥혈압에서는 유의적인 변화가 나타나지 않았으며 동맥혈 가스분석 결과에서도 유의적인 차이가 없었다. 이상의 결과로 보아 개에서 아이소플루란을 이용한 전신마취 시 트라마돌의 투여는 심폐기능의 억압을 일으키지 않고 $MAC_{ISO}$값을 감소시켰으므로 마취의 안정성과 마취회복의 질을 향상시키는데 유용할 것으로 사료된다.

Keywords

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