대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)

  • 제29권2호
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  • Pages.59-77
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  • 2015
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  • 1226-8038(pISSN)
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  • 2287-9463(eISSN)
대한한방소아과학회 (The Association of Korean Oriental Pediatrics)
권호 표지
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식물성에스트로겐 작용이 보고된 한약재에 관한 고찰

The Review of the Herbal Medicines with Phytoestrogenic Effect

  • 이선행 (강동경희대학교병원 한방소아과, 경희대학교 대학원 임상한의학과 소아과학교실) ;
  • 김형중 (강동경희대학교병원 한방소아과, 경희대학교 대학원 임상한의학과 소아과학교실) ;
  • 이은주 (강동경희대학교병원 한방소아과, 경희대학교 대학원 임상한의학과 소아과학교실) ;
  • 장규태 (강동경희대학교병원 한방소아과, 경희대학교 대학원 임상한의학과 소아과학교실)
  • Lee, Sun Haeng (Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong / Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Hyung Joong (Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong / Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Eun Ju (Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong / Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Chang, Gyu Tae (Department of Pediatrics of Korean Medicine, Kyung Hee University Hospital at Gangdong / Pediatrics of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 투고 : 2015.05.03
  • 심사 : 2015.05.15
  • 발행 : 2015.05.31
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초록

Objectives Medical plant has a big role in Herbal Medicines, and most medical plant has phytoestrogens. Therefore some estrogenic effects have been reported in a lot of Korean Medicine literature. Phytoestrogens should be used carefully in children. The objective of this study is to identify reported phytoestrogenic effects in Herbal Medicines and to evaluate the characteristics of the phytoestrogens in Herbal Medicines. Methods A literature search was done with using 8 databases with a limit of reports until 12/31/2013. The estrogenic effects were summarized by each individual Korean Medicine. The frequency of the phytoestrogens was also investigated depending on the Korean medical categorization by the treatment effect. Results and Conclusions Phytoestrogenic effects were reported in 89 Herbal Medicines. Phytoestrogens were act bidirectionally, and the effect was fairly weak compared to estrogen. Phytoestrogenic effect was variable on different cells and tissues. The most frequent phytoestrogenic effect was in tonifying and replenishing medicinal, the following orders were heat-clearing, exterior-releasing, and blood-activating and stasis-dispelling medicinal. Phytoestrogens were not reported in dampness-resolving, digestant, orifice-opening, emetic medicinal.

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참고문헌

  1. Ark HM. The efficacy of phytoestrogen in postmenopausal women. Korean J Obestet Gynecol. 2007;50(3):389-415.
  2. U LG, Chen ZQ, Wang SS, Bai ZG, Wang ZH, Dai RX, Tang GX, Fu W. The review of the effect of traditional Chinese medicine containing hormones on the hormone level of human body and the action in the treatment and prevention of tumor. J New Chin Med. 2012;44(9):95-7.
  3. Uang GX, Zhao JL, Yang J, Yao H, Cheng Y. Application and new progress of phyto-estrogen. Inner Mongolia Med J. 2005;37(1):26-8.
  4. Im KH. A bibliographic study on the orgin-habitats in 24 kinds of Leguminosae. Wanju: Woosuk Univ. 2006.
  5. Li MC. How to use traditional Chinese medicine including phytoestrogen for treatment. Seeking Dr Asking Med. 2011;(12):9-11.
  6. Schneyer A, Brown M. Altered glucose homeostasis resulting from developmental exposures to endocrine disruptors. In: Endocrine disruptors and puberty. New York: Humana Press Contemporary Endocrinology. 2012:277.
  7. Garry VF, Truran P. Secular trends in pubertal timing: a role for environmental chemical exposure? In: Endocrine disruptors and puberty. New York: Humana Press Contemporary Endocrinology. 2012:364.
  8. Tan QH. The overview of phytoestrogen prevention of ischemic stroke. Hunan J Tradit Chin Med. 2001;17(4):56-7.
  9. Mantovani A. Endocrine disruptors and puberty disorders from mice to men (and women). In: Endocrine disruptors and puberty. New York: Humana Press Contemporary Endocrinology. 2012:132.
  10. Bourguignon J, Parent A. The impact of endocrine disruptors on female pubertal timing. In: Endocrine disruptors and puberty. New York: Humana Press Contemporary Endocrinology. 2012:327.
  11. Patisaul HB. Effects of environmental endocrine disruptors and phytoestrogens on the kisspeptin system. Adv Exp Med Biol. 2013;784:455-79. https://doi.org/10.1007/978-1-4614-6199-9_21
  12. Textbook compliation committee. Herbal medicine. Seoul: Younglimsa. 2005.
  13. Zhang Y, Chen J, Zhang C, Wu W, Liang X. Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography. J Steroid Biochem Mol Biol. 2005;94(4):375-81. https://doi.org/10.1016/j.jsbmb.2004.10.022
  14. Ha H, Lee YS, Lee JH, Choi H, Kim C. High performance liquid chromatographic analysis of isoflavones in medicinal herbs. Arch Pharm Res. 2006;29 (1):96-101. https://doi.org/10.1007/BF02977475
  15. Kim SJ, Park C, Kim HG, Shin WC, Choe SY. A study on the estrogenicity of Korean Arrowroot (Pueraria thunbergiana). J Korean Soc Food Sci Nutr. 2004;33(1):16-21. https://doi.org/10.3746/jkfn.2004.33.1.016
  16. Boue SM, Wiese TE, Nehls S, Burow ME, Elliott S, Carter-Wientjes CH, Shih BY, McLachlan JA, Cleveland TE. Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. J Agric Food Chem. 2003;51(8):2193-9. https://doi.org/10.1021/jf021114s
  17. Xue XO, Jin H, Niu JZ, Wang JF. Effects of extracts of root of Kudzu Vine on mammary gland and uterus development in rats. China J Chin Mater Med. 2003;28(6):560-2.
  18. Wang JF, Guo YX, Niu JZ, Liu J, Wang LQ, Li PH. Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats. World J Gastroenterol. 2004;10(13):1967-70. https://doi.org/10.3748/wjg.v10.i13.1967
  19. Wang XX, Zhang YL, Wu J, Chiba T, Yamada K, Iwami Y. The effects of puerariae radix on bone mass and bone microarchitecture in ovariectomy mice. Chin J Osteoporos. 2008;14(5):349-54.
  20. Kim C, Ha H, Kim H, Lee JH, Song KY. Pueraria lobata Ohwi as an osteoporosis therapeutics. Korean J Food Sci Technol. 2002;34(4):710-8.
  21. He HL, Jin H, Wang JF, Niu JZ. The research of estrogen receptor modulator and correlative Chinese herbs. China J Chin Mater Med. 2002;27 (11):805-7.
  22. Wang JB, Zheng TZ. The research progress of hormone relating obesity and treatment. LiShiZhen Med Mater Med Res. 2004;15(5):309-10.
  23. Zhang XH, Liu SX, Xu M. The research of phytoestrogen and chinese herb. Tradit Chin Drug Res Clin Pharmacol. 2002;13(4):261-4.
  24. Song HS, Suo CZ. The research progress of phytoestrogen and its effect on central nervous system. Liaoning J Tradit Chin Med. 2006;33(10):1372-3.
  25. Zhu DN, Wang L, Wang ST, Zhang WS. Advances in studies on phytoestrogens. Chin Tradit Herb Drugs. 2012;43(7):1422-9.
  26. Oerter Klein K, Janfaza M, Wong JA, Chang RJ. Estrogen bioactivity in fo-ti and other herbs used for their estrogen-like effects as determined by a recombinant cell bioassay. J Clin Endocrinol Metab. 2003;88(9):4077-9. https://doi.org/10.1210/jc.2003-030349
  27. Choi SY, Lim SH, Kim JS, Ha TY, Kim SR, Kang KS, Hwang IK. Evaluation of the estrogenic and antioxidant activity of some edible and medicinal plants. Korean J Food Sci Technol. 2005;37(4):549-56.
  28. Jo EH, Kim SH, Ra JC, Kim SR, Cho SD, Jung JW, Yang SR, Park JS, Hwang JW, Aruoma OI, Kim TY, Lee YS, Kang KS. Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells. Cancer Lett. 2005;230(2):239-47. https://doi.org/10.1016/j.canlet.2004.12.038
  29. Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem. 2001;49(5):2472-9. https://doi.org/10.1021/jf0014157
  30. Zhao PW, Wang DW, Wang LQ, Niu JZ, Wang JF. Screening of ten kinds of Chinese herbal drugs including Herba Epimedii with estrogenic effects by uterus growth test in mice. J Beijing Univ Tradit Chin Med. 2006;29(10):686-9.
  31. Dai Y, Dai DJ, He FJ, Song Y, Jiao LQ, Liu JX. Study of the mechanism of the effects of 4 Chinese herbal drug extracts on liver lipid metabolism in ovariectomized rats. J Beijing Univ Tradit Chin Med. 2002;25(6):45-7.
  32. Palida A, Rana K, Sheng p, Cong YY, Masso H. Experimental study on estrogenic activities of nine kinds of Chinese herbal medicines. LiShiZhen Med Mater Med Res. 2008;19(9):2237-8.
  33. Wang RG, You ZL, Ma HX. The correlation between phytoestrogens and traditional Chinese medicine active ingredients. Acta Chin Med Pharmacol. 2003; 31(5):31-2.
  34. Wu CT, Tzeng JN, Lai JN, Tsan SH, Wang JD. Prescription profile of Chinese herbal products containing coumestrol, genestein, and/or daidzein among female users: an analysis of national health insurance data in Taiwan between 1997 and 2007. Chin Med. 2012;7(1):22. https://doi.org/10.1186/1749-8546-7-22
  35. Yang LJ, Huang JM, Wang F. Evaluation of the phytoestrogenic activity of Polygoni Multiflori Radix, Drynariae Rhizoma and Epimedii Folium. Pharm Clin Chin Mater Med. 2012;3(3):37-40.
  36. Zheng XK, Lv PF, Wang LQ, Feng WS, Wang JF, Niu JZ. Experimental study on estrogenic activities of five kinds of Chinese herbal medicines. China J Chin Mater Med. 2006;31(15):1254-7.
  37. Wei HM, Wang JB. The study in the development of the traditional Chinese medicine Fructus Sophorae. Asia Pac Tradit Med. 2010;6(3):115-9.
  38. Li G, Sepkovic DW, Bradlow HL, Telang NT, Wong GY. Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism. Nutr Cancer. 2009;61(3):408-14. https://doi.org/10.1080/01635580802585952
  39. Palida A, Wang XW, Rana K. The experimental study of phytoestrogenic activity of 9 kinds of natural medicines including Xinjiang Granati Pericarpium. LiShiZhen Med Mater Med Res. 2010;21(1):112-3.
  40. Li BR, She YC. The effect of tonifying kidney herbs on hypothalamus-pituitary-gonadal axis function. J Tradit Chin Med. 1984;25(7):63.
  41. Niu JZ, Zhao PW, Wang JF, Yu J, Wang DW, Shen LX. Phytoestrogenic activity of five kinds of Chinese herbal medicines including Fructus Psoraleae. J Beijing Univ Tradit Chin Med. 2008;31(10):676-81.
  42. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause. 2002;9(2):145-50. https://doi.org/10.1097/00042192-200203000-00010
  43. Hao QX, Wang JF, Niu JZ, Zhao PW, Cui Y, Xue XO. Study on phytoestrogenic-like effects of four kinds of Chinese medicine including Radix Rehmanniae Preparata, Radix Paeoniae Alba, Radix Angelicae Sinensis, Rhizoma Chuanxiong. China J Chin Mater Med. 2009;34(5):620-4.
  44. Lau CB, Ho TC, Chan TW, Kim SC. Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate? Menopause. 2005;12(6):734-40. https://doi.org/10.1097/01.gme.0000184419.65943.01
  45. Rosenberg Zand RS, Jenkins DJ, Diamandis EP. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim Acta. 2001;312(1-2):213-9. https://doi.org/10.1016/S0009-8981(01)00626-X
  46. Tao SY, Niu JZ, Wang JF, Zhao PW. Effects of Er-xian decoction and its component herbs on estrogen receptors in adrenal development rats. Chin J Inf Tradit Chin Med. 2010;17(5):36-46.
  47. Tao SY, Niu JZ, Zhao PW, Wang JF, Yang MJ. Effects of Er-xian decoction and its compositions on uterus in immature rat. Chin J Exp Tradit Med Formulae. 2010;16(18):118-21.
  48. Circosta C, Pasquale RD, Palumbo DR, Samperi S, Occhiuto F. Estrogenic activity of standardized extract of Angelica sinensis. Phytother Res. 2006; 20(8):665-9. https://doi.org/10.1002/ptr.1928
  49. Park MK, Rhyu M, Yoon BK, Kwon H, Jang S, Lee YJ. Modulation of the genomic estrogen receptor pathway by water extracts of Cirsium japonicum. Arch Pharm Res. 2008;31(2):225-30. https://doi.org/10.1007/s12272-001-1145-y
  50. Lu YY, Su SB. The study on phytoestrogen of traditional Chinese medice and breast cancer. Chin Tradit Pat Med. 2010;32(6):1010-4.
  51. Usui T, Ikeda Y, Tagami T, Matsuda K, Moriyama K, Yamada K, Kuzuya H, Kohno S, Shimatsu A. The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. J endocrinol. 2002;175(2):289-96. https://doi.org/10.1677/joe.0.1750289
  52. Yang S, Zhu GQ, Li QL. The survey of pharmacological effects and mechanism of phytoestrogenic compounds. J Anhui Tradit Chin Coll. 2010;29 (2):76-8.
  53. Xin D, Wang H, Yang J, Su YF, Fan GW, Wang YF, Zhu Y, Gao XM. Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity. Phytomedicine. 2010;17(2):126-31. https://doi.org/10.1016/j.phymed.2009.05.015
  54. Liu ZP, Lu CQ, Chen JS. Correlation comparison of uterotrophic assay and E-SCREEN assay for estrogenic activities. J Hyg Res. 2004;33(4):458-60.
  55. Xiang P. The experimental observation about anti- aging effect of seven kinds of traditional Chinese medicine (preliminary report). Liaoning J Tradit Chin Med. 1982;(3):4.
  56. Lee HD. A study on oriental medicinal herbs of estrogen receptor modulating activity. Gyeongbuk, Korea: Grad School Daegu Haany Univ; 2009.
  57. Guo AJ, Choi RC, Zheng KY, Chen VP, Dong TT, Wang ZT, Vollmer G, Lau DT, Tsim KW. Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. Chin Med. 2012;7:10. https://doi.org/10.1186/1749-8546-7-10
  58. Guo HP, Liu XY, Liu PX, Chen XY, Wei XW. The effect of Curculiginis Rhizoma, Epimedii Herba granule on the proliferation of MCF-7 breast cancer cells. J Chin Med Mater. 2008;31(5):731-3.
  59. Vijayanarayana K, Rodrigues RS, Chandrashekhar KS, Subrahmanyam EV. Evaluation of estrogenic activity of alcoholic extract of rhizomes of Curculigo orchioides. Jo Ethnopharmacol. 2007;114(2):241-5. https://doi.org/10.1016/j.jep.2007.08.009
  60. Malini T, Vanithakumari G, Megala N, Anusya S, Devi K, Elango V. Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats. Indian J Physiol Pharmacol. 1985;29(1):21-6.
  61. Peng GR, Xu ZQ, Zeng XG, Shen JY, Zhao SR, Yang XH. The preliminary observation of the Schizandrae Fructus about the effect on the genitourinary enzyme histochemistry and anti-aging of the rabbit. Shanghai J Tradit Chin Med. 1989(2):43.
  62. Sang SM, Lao AN, Wang HC, Chen ZL. The study of the chinese herb chemical composition of Vaccariae Semen (II). Chin Tradit Herb Drugs. 2000;31 (3):169-71.
  63. Wang ZQ, Lou YJ. Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. Eur J Pharmacol. 2004;504(3):147-53. https://doi.org/10.1016/j.ejphar.2004.10.002
  64. Shen P, Guo BL, Gong Y, Hong DY, Hong Y, Yong EL. Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Phytochemistry. 2007;68(10):1448-58. https://doi.org/10.1016/j.phytochem.2007.03.001
  65. Kang HK, Choi YH, Kwon H, Lee SB, Kim DH, Sung CK, Park YI, Dong MS. Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies. Food Chem Toxicol. 2012;50(8):2751-9. https://doi.org/10.1016/j.fct.2012.05.017
  66. Yap SP, Shen P, Li J, Lee LS, Yong EL. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol. 2007;113(2):218-24. https://doi.org/10.1016/j.jep.2007.05.029
  67. Kang HK, Lee SB, Kwon H, Sung CK, Park YI, Dong MS. Peripubertal administration of icariin and icaritin advances pubertal development in female rats. Biomol Ther. 2012;20(2):189-95. https://doi.org/10.4062/biomolther.2012.20.2.189
  68. Wang F, Zheng Y, Xiao HB, Zhou M, Liu YX, Li GQ. Effect of administration of Herba Epimedii at the optimal time on levels of sexual hormones. J Tradit Chin Med. 2001;42(10):619-20.
  69. Gray SL, Lackey BR, Tate PL, Riley MB, Camper ND. Mycotoxins in root extracts of American and Asian ginseng bind estrogen receptors alpha and beta. Exp Biol Med. 2004;229(6):560-8. https://doi.org/10.1177/153537020422900615
  70. Zhou RF, Li XY, Liu PX. Effects of phytoestrogen- containing herbs on cell proliferation of mammary tumor. J Int Oncol. 2006;33(11):838-41.
  71. Polan ML, Hochberg RB, Trant AS, Wuh HC. Estrogen bioassay of ginseng extract and ArginMax, a nutritional supplement for the enhancement of female sexual function. J Womens Health. 2004;13 (4):427-30. https://doi.org/10.1089/154099904323087114
  72. Park Y, Lee WY, Ahn JK. Quantification of phytoestrogens in woody plants (leguminosae) using HPLC. Mokchae Konghak. 2004;32(6):1-6.
  73. Zhu JF, She YC, Zhou CH. A study-on-the effect of Shou Tai pill in treating threatened abortion. Chin J Integr Tradit West Med. 1987;7(7):407.
  74. Zhang ZB, Yang QT, Yang JQ, Zheng JH, Zhou DR. Comparative studies on protective effects on reproduction of icariin and the substance extracted from the semen cuscutae in rats with partial androgen deficiency. Chin J Gerontol. 2006;26(10):1389-91.
  75. Zhang YC, Zhang H, Su GZ, Su YL. Analysis of radix Astragali's extracts in local treating senile vaginitis. Shandong Med J. 2005;45(3):12-4.
  76. Huang Y, Qin MJ, Yu GD. The distribution and pharmacological action of isoflavone compounds in plantae. Chin Wild Plant Resour. 2001(1):5-7.
  77. Zhang SY, Meng L, Gao WY, Song NN, Jia W, Duan HQ. Advances on biological activities of coumarins. China J Chin Mater Med. 2005;30(6):410-4.
  78. Shiizaki K, Goto K, Ishige A, Komatsu Y. Bioassay of phytoestrogen in herbal medicine used for postmenopausal disorder using transformed MCF-7 cells. Phytother Res. 1999;13(6):498-503. https://doi.org/10.1002/(SICI)1099-1573(199909)13:6<498::AID-PTR495>3.0.CO;2-J
  79. Malaivijitnond S, Chansri K, Kijkuokul P, Urasopon N, Cherdshewasart W. Using vaginal cytology to assess the estrogenic activity of phytoestrogen-rich herb. J Ethnopharmacol. 2006;107(3):354-60. https://doi.org/10.1016/j.jep.2006.03.026
  80. Wei SL, Zhang ZM, Xu JS. Research progress in phytoestrogen effect of Chinese medicine and breast cancer. Med Recapitulate. 2012;18(17):2794-6.
  81. Song ZM, Li YF. The progress in research of breast cancer relating phytoestrogen and traditional Chinese medicine. Shanxi J Tradit Chin Med. 2012;28(8):54-5.

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