The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Effects of Cicadae Periostracum (CP) in Allergic Contact Dermatitis (ACD) Induced by DNCB in Mice

DNCB로 유발된 생쥐의 알레르기성 접촉피부염에 선태(蟬蛻)가 미치는 영향

  • Kim, Bit Na Rae (Department of Pediatrics, College of Oriental Medicine, Dongshin University) ;
  • Chae, Jung Won (Department of Pediatrics, College of Oriental Medicine, Dongshin University)
  • 김빛나래 (동신대학교 한의과대학 소아과학교실) ;
  • 채중원 (동신대학교 한의과대학 소아과학교실)
  • Received : 2015.04.06
  • Accepted : 2015.05.15
  • Published : 2015.05.31
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Abstract

Objectives In the theory of Korean Medicine, Cicadae Periostracum (CP) has been used to treat skin diseases such as inflammatory dermatitis, tetanus and pruritus. CP can reduce heat and disperse wind. In prior studies, anti-allergic effect and anti-inflammatory effect of CP were reported. However, there has been no report regarding the correlation of CP and allergic contact dermatitis (ACD). This study was performed to show the effects of CP in ACD induced by 2,4-dinitrochlorobenzene (DNCB) in mice. Methods In this experiment, the effects of CP on biological changes were measured, such as changes in ear and spleen weight, ear and dorsum skin thickness, clinical aspect on the dorsum skin and histological changes. The effect of proliferation rate of splenocytes was also investigated in vitro and vivo study. Results In results, CP application (CPA) group and CP application and administration (CPAA) group were significantly restrained in ear weight gain and increase in ear and dorsum skin thickness compared to the control group. In addition, CPA and CPAA group showed diminished erythema, desquamation, bloodstain, and marks. Also, the histological assessment showed that CP treatement diminished thickness of epidermis, hyperkeratosis, pigmentation and parakeratosis. Conclusions In conclusion, these data suggest that CP can decrease symptoms of ACD.

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References

  1. Korean J Asthma Allergy Clin Immunol. Asthma and allergic diseases. Seoul: RyoMoonGak Publishing Co. 2012:27, 43, 45, 431-41.
  2. Kim KB, Kim DG, Kim YH, Kim JH, Min SY, Park EJ, Baek JH, Yu SA, Lee SY, Lee JY, Lee HJ, Chang GT, Chae JW, Han YJ, Han JK. Pediatrics of korean medicine, 1st ed. Seoul: EuiSungDang Publishing Co. 2010:727-8.
  3. Chonnam National University Graduate Medical School Allergy & Clinical Immunology compilation committee. Allergy & clinical immunology. Jeonnam: Chonnam National Univ Press. 2013:43-4.
  4. Seoul National University College of Medicine Dermatology. Dermatology, 3rd ed. Seoul: Korea EuiHak. 2011:32-6.
  5. Hong CS. Steps to internal medicine - immunity & allergy. Seoul: JungDam Publishing Co. 2008:46-7.
  6. NamkyeongJungeuiHakwon. Jebyeongwonhuron Kyoseok Ha, 1st ed. Beijing: InMinWiSaeng Publishing Co. 1982:987-8.
  7. Oh K. Daesuk Euijongkeumgam. Seoul: JiSan Publishing Co. 2008:650, 996.
  8. Ko SJ. YangEuiDaeJeon. Beijing: InMinWiSaeng Publishing Co. 1996:475.
  9. Dam SH, Yuk DM. Jungeuioekwahak. Beijing: InMinWiSaeng Publishing Co. 2001:755-6.
  10. Jeon JH, Kim HA, Kang YH. The literature study on contact dermatitis. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 1997;10(1):263-83.
  11. Hanuigwadaehak Bonchohak Pyeonchanwiwonhoe. Bonchohak. Seoul: YeongRimSa Publising Co. 2011: 195-7.
  12. Kim CM, Sin MK, An DK, Lee KS. Jungyakdaesajeon. JungDam Publishing Co. 2004:2349-51.
  13. Lee SJ. Bonchogangmok. Tokyo: Taejindang Publishing Co. 1992:173-4.
  14. Heo J. Donguibogam. Gyeongnam: Donguibogam Publishing Co. 2010:476, 726, 730-1, 1546, 1599, 1604-5, 1651, 1905, 1917, 1938.
  15. Park BM, Kim KH. Effect of Cicadidae Periostracum on the anti-allergic reaction in rats and mouse. Korean J Orient Physiol Pathol. 1993;8:225-34.
  16. Kim KW, Cho HB, Kim SB, Choe CM, Seo YJ. The anti-inflammatory effects of Cicadidae Periostracum. J Korean Obstet Gynecol. 2011;24(1):15-26. https://doi.org/10.15204/JKOBGY.2011.24.1.015
  17. Yuan XY, Liu W, Zhang P, Wang RY, Guo JY. Effects and mechanisms of aloperine on 2,4-dinitrofluorobenzene- induced allergic contact dermatitis in BALB/c mice. Eur J Pharmacol. 2010;10:629(1-3) :147-52. https://doi.org/10.1016/j.ejphar.2009.12.007
  18. Heo H. A practical guide to 60 skin diseases. Ulsan: UUP. 2007:137-9.
  19. Kang WH. Atlas of skin disease, 2nd ed. Seoul: Hanmieuihak Publishing Co. 2008:103-6.
  20. Korean Dermatological Association Press. Dermatology, 5th ed. Seoul: RyoMoonGak Publishing Co. 2008: 179-85.
  21. Jung JY, Han KH. Common skin diseases in korea. Seoul: MDworld. 2009:16-48.
  22. Jeon JH, Kim HA, Kang YH. A literature study on the external therapy of contact dermatitis. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 1998; 11(1):197-218.
  23. Kim JJ, Kim HT. The effects of Naetakchunkeum-san on the allergic contact dermatitis induced by DNCB. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2009;22(1):46-61.
  24. Lee YS, Yoon JH, Kim BA, Park CI, Yoo WK, Cho JW, Kim MR. Effects of Horse oil on the DNCB-induced contact hypersensitivity in Balb/c mice. Korean J Herbology. 2014;28(4):77-81.
  25. Leung DYM, Soter NA. Cellular and immunologic mechanisms in atopic dermatitis. J Am Acad Dermatol. 2001;44(1):S1-12. https://doi.org/10.1067/mjd.2001.109302
  26. Jun JH, Kang YH. The effects of scutellaria baicalerisis GEORGI on allergic contact dermatitis induced by DNCB in Mice. Dongguk J Orient Med ins. 1998;7(1):119-33.
  27. Shin KS, Son JS, Kim DU, Jeon WJ, Jung SH, Shin KJ, Lee WC. The effect of Rhemanniae radix extract on allergic contact dermatitis on mice induced by DNCB. Korean J Herbal Formula Science. 2000; 8(1):257-79.
  28. Kim SC, Lee JR, Choi KI, Park SJ, Kwon YK, Byun SH. Effect of Lonicerae Flos-Slin on contact hypersensitivity induced by repeat elicitation of DNCB. Korean J Herbology. 2006;21(1):9-15.
  29. Soon JS, Lee JC, Choi JH, Kim JH, Park SY. Effects of Scropohulariae Radix on allergic contact dermatitis induced by DNCB in mice. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2011;24(3):1-16.
  30. Lee JC, Park SY, Choi JH, Kim JH. Effects of Portulacae Herba on allergic contact dermatitis induced by DNCB in mice. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2014;27(3):115-32. https://doi.org/10.6114/jkood.2014.27.3.115
  31. Kim HW, Ryu JH, Jo SZ, Cheon WJ, Son YH, An WG, Cho SI. Effects of Sophorae Radix on skin condition in mice with contact dermatitis induced by dinitrofluorobenzene. Korean J Herbology. 2013; 28(6):25-9.
  32. Kwon OS, Kim JT, Park IS, Ahn SH, Lee HP, Kim HH, Gang YH. The effect of Yunkyopaedosangamibang on allergic contact dermatitis. Dongguk J Orient Med ins. 1999;8(1):77-91.
  33. Kang YH, Kim JT, Kim SA. The effects of Hangryunhaedocktang on allergic contact dermatitis based on the morphological changes in epidemal damage in mice. Korean J Orient Int Med. 2004; 25(3):508-17.
  34. Nam BS, Kim YB. The effects of Sanpunggosamhwan on the allergic contact dermatitis. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2005;18(2): 10-27.
  35. Cho SW, Park SS. Effects of Yangkyuksanhawtang on the allergic contact dermatitis. J Sasang Const Med. 2001;13(3):89-101.
  36. Byun SH, Lee BW, Lee SC. Effect of Samyoyongantang on contact hypersensitivity induced by repeat elicitation of DNCB. Korean J Herbal Formula Science. 2005;13(2):59-69.
  37. Kim NH, Kim KJ. The anti-inflammatory effects of WooBangHaeGiTang on the allergic contact dermatitis. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2006;19(2):59-70.
  38. Park SJ, Lee SK, Byun SH, Baek JH, Kim SC. Effect of Sopung-san on contact hypersensitivity induced by repeat elicitation of DNCB. Korean J Orient Physiol Pathol. 2006;20(3):623-8.
  39. Bae EY, Kim DH. Effect of Geopungjeseupbang on contact dermatitis induced by DNCB. Korean J Orient Physiol Pathol. 2007;21(6):1491-8.
  40. Kim SH, Kim HT. The effects of Gyejijakyakjimo-Tang on the allergic contact dermatitis induced by DNCB. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2010;23(1):8-22.
  41. Hahn BS, Wu SJ, Kim SW, Kim YS. Evaluation of anticoagulant and fibrinolytic activities from Crude Extracts of Insects. Korean J Pharmacogn. 1999;30(4): 409-12.
  42. Roh SS, Kim SM, Seo BI. A philological study on poisoning and adverse reaction of Cicadae Periostracum. J Jeahan Orient Med Acad. 2011;9(1):13-8.
  43. Park EJ, Kim YG. Effects of Cheonggisan and Gagamcheonggisan on the anti-allegic and immune responses in mice. J Korean Orient Pediatr. 1998; 12(1):183-210.
  44. Kim JJ, Yank SW, Son NW, Ahn KS. Anti-inflammatory action by Gamisangryosamul-tang and the effect of Ziyang-Go on atopic dermatitis-like lesion and pruritus in NC/Nga mice. Korean J Orient Physiol Pathol. 2003;17(2):428-35.
  45. Jin GH, Jin MR, Choi JM, Yun MY, Kim DH. Suppression of spontaneous dermatitis in Nc/Nga atopic model by Gamipaidok-san, a traditional herbal medicine. Korean J Orient Physiol Pathol. 2006; 20(4):866-74.
  46. Ahn SH, Kim HH, Kim JT. Cheonggi-san inhibits atopy dermatitis in NC/Nga mouse through regulation of iNOS mRNA expresssion & NO production. Korean J Orient Physiol Pathol. 2007;21(5):1092-8.
  47. Song HJ, Han JK, Kim YH. A clinical study on the treatment of atopic dermatitis by using Kami-chungsimyeunjatang. J Pediatr Korean Med. 2007;21(3):21-31.
  48. Kim YH, Han JK. Effect of Kami-kanghwalsan (KKHS) on atopic dermatitis-like skin lesions induced in NC/Nga mouse by mite antigen stimulation. J Pediatr Korean Med. 2008;22(1):69-93.
  49. Dan Longo, Anthony Fauci, Dennis Kasper, Stephen Hauser, J Jameson, Joseph Loscalzo. Harrisons's Principles of Internal Medicine, 18th ed. Seoul: MIP. 2013:454-8.
  50. Ryu HS, Kim J, Park SL, Kim HS. Enhancing effect of Zingiber Officinale Roscoe extracts on mouse spleen and macrophage cells activation. Korean J Nutrition. 2004;37(9):780-5.

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