Archives of Craniofacial Surgery (대한두개안면성형외과학회지)

Korean Cleft Palate-Craniofacial Association (대한두개안면성형외과학회)
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Comparison of Prostaglandin E1 and Sildenafil Citrate Administration on Skin Flap Survival in Rats

  • Choi, Ji-An (Department of Plastic and Reconstructive Surgery, Dong-A University School of Medicine) ;
  • Lee, Keun-Cheol (Department of Plastic and Reconstructive Surgery, Dong-A University School of Medicine) ;
  • Kim, Min-Su (Department of Plastic and Reconstructive Surgery, Dong-A University School of Medicine) ;
  • Kim, Seok-Kwun (Department of Plastic and Reconstructive Surgery, Dong-A University School of Medicine)
  • Received : 2015.06.19
  • Accepted : 2015.08.05
  • Published : 2015.08.09
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Abstract

Background: Alprostadil and sildenafil are known vasodilators used independently to improve flap survival in animal models. In this study, we investigate whether these agents act synergistically to decrease flap necrosis in rat models. Methods: After acclimation period, 4 groups of 10 male white rats were given a modified McFarlane skin flap. The postoperative treatment included saline control (Group A), sildenafil citrate-only (Group B), alprostadil-only (Group C), and both sildenafil and alprostadil (Group D). The flaps were observed on postoperative days 1, 3, 5 and 7. The animals were euthenized on postoperative day 7, and the flaps were evaluated for inflammation and neovascularization. Results: At each observation, the mean necrotic index was significantly lower for all three treatment groups (Groups A, B, C) and was the lowest for the combined treatment group. On histologic evaluations, combined treatment was associated with decreased inflammation and increased capillary vessel formation, when compared with control group. Conclusion: Both sildenafil-only and alprostadil treatments were independently associated with increased flap survival rate. Sildenafil citrate and alprostadil had a synergistic effect in increasing flap survival rate.

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References

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