Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지
DOI QR코드

DOI QR Code

The Effects of Sophorae Radix Pharmacopuncture Therapy on the Chunchu(ST25) for DSS-induced Colitis in Rats

천추(天樞)(ST25) 고삼약침(苦蔘藥鍼)이 DSS로 유발된 대장염 백서에 미치는 영향

  • Received : 2015.05.11
  • Accepted : 2015.06.04
  • Published : 2015.06.20
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this study is to investigate the effects of Sophorae radix pharmacopuncture(SRP) therapy on the Chunchu($ST_{25}$) on intestinal disease in rats with dextran sulfate sodium(DSS)-induced colitis. Methods : The experimental model of colitis was induced by an infection of DSS for fifteen days. After colitis was induced, SRP therapy was practiced on the Chunchu($ST_{25}$) once every three days for a total of five times. Afterward, colon length, damage to the colonic mucosa, complete blood count, aspartate aminotransferase(AST), alanine transferase(ALT), blood urea nitrogen(BUN), creatinine, TNF-${\alpha}$ and IL-6 were measured. Results : The results were obtained as below. 1. Colon length was significantly increased in the SRP group 2 compared to the control group. 2. Damage of colonic mucosa was observed less in the SRP groups than in the other groups. 3. The mean rates of white blood cell(WBC), neutrophils and lymphocytes were significantly increased in SRP group 2 compared to the control group. 4. The mean rates of HGB and hematocrit(HCT) were significantly increased in the SRP compared to the control group. 5. No significant differences were shown in AST, ALT, BUN and Creatinine between the SRP groups and the control group. 6. The mean rate of TNF-${\alpha}$ was significantly decreased in the SRP groups compared to the control group. 7. The mean of IL-6 was significantly decreased in the SRP groups compared to the control group. Conclusions : These results indicated that SRP therapy on Chunchu($ST_{25}$) functions as a treatment to the dextran sulfate sodium-induced colitis.

Keywords

References

  1. Department of Internal Medicine, Seoul National University College of Medicine. Update in internal medicine I. Seoul : Koonja. 1997 : 420-36.
  2. Braunwald, Fauci, Kasper, Haiser, Longo, Jameson. Harrison's principles of internal medicine. 15th ed. Seoul : MIP. 2010 : 2273-77.
  3. Kang TH, Won JH. Study on the treatment of ulcerative colitis in oriental medicine. J of Oriental Chr Dis. 1999 ; 5(1) : 137-62.
  4. An CB. Hyeondae Imsangchimguhag. Seoul : Euiseongdang. 2000 : 347-62.
  5. Korean Acupuncture & Moxibustion Medicine Society. The acupuncture and moxibustion medicine 2nd vol. Gyeonggi : Jipmoondang. 2008. vol 1 : 56-7. vol 2 : 138, 493.
  6. Jeongughanuigwadaehag Bonchohaggongdonggyojae Pyeonjibwiwonhoe. Bonchohag. Seoul : Yeonglimsa. 2008 : 225-6.
  7. Song YG, Ryu BH, Yoon SW. The effects of Soyumjungjang-tang on DSS-induced Ulcerative colitis in mouse. Korean J Orient Int Med. 2008 ; 29(2) : 385-400.
  8. Lee SH, Choi HM, Lim SW. Effects of Jiyutang on DSS-induced colitis of the mouse. J Korean Med. 2007 ; 28(1) : 187-97.
  9. Lee JA. Effects of Doche-tang on colonic mucosal Ulcer induced by DSS in mice. Jecheon : Semyung Univ. 2008. Korean.
  10. Park SK. The anticolitic effect of Bokijeongjangtang in mice treated with DSS-induced Ulcerative colitis. Seoul : Kyunghee Univ. 2008. Korean.
  11. Myung NY. The inhibitory effect of Orostachys japonicus on dextran sulfate sodium-induced colitis in mice. Kor J Herbology. 2014 ; 29(4) : 29-34. https://doi.org/10.6116/kjh.2014.29.4.29
  12. Jung JW, Oh SR, Ahn EM, Yang EJ, Kim SJ. The beneficial effect of Adenophorae Radix on DSSinduced colitis in Mice. J Exp Biomed Sci. 2013 ; 19(3) : 188-94.
  13. Lee SH, Lim BO, Choue RW. Immunoregulatory effects of water extracts of Scutellariae Radix in DSS-Induced inflammatory bowel disease animal Model. J Nutr Health. 2004 ; 37(6) : 431-9.
  14. Choi DH, Kim WI, Kim MR, Youn DH, Na CS. Laser acupuncture treatment on the five transport points of the spleen meridian in dextran-sulfatesodium-induced-colitis in rats. Korean J Acupunct. 2014 ; 31(2) : 56-65. https://doi.org/10.14406/acu.2014.011
  15. Kim SJ, Park SK. Antioxidative and antiinflammatory effects of Aurantii Fructus Immaturus pharmacopuncture. Korean J Acupunct. 2010 ; 27(2) : 13-24.
  16. Park SI. Effects of moxi-tar herbal acupuncture of Gokji(LI11) on inflammatory bowel disease induced by DSS in mice. Iksan : Wonkwang Univ. 2008. Korean.
  17. Park KJ. Effects of moxi-tar herbal acupuncture of $ST_{25}$ on dextran sulfate sodium-induced colitis in mice. Iksan : Wonkwang Univ. 2005. Korean.
  18. Song IS. Inflammatory bowel disease in Korean. J Korean Med. 1999 ; 57(4) : 661-74.
  19. Nikolaus S, Schreiber S. Diagnostics of inflammatory bowel disease. Gastroenterology. 2007 ; 133(5) : 1670-89. https://doi.org/10.1053/j.gastro.2007.09.001
  20. Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The montreal classification of inflammatory bowel disease: controversies, consensus and implications. Gut. 2006 ; 55(6) : 749-53. https://doi.org/10.1136/gut.2005.082909
  21. Fiocchi C. Inflammatory bowel disease: dogmas and heresies. Dig Liver Dis. 2002 ; 34(4) : 306-11. https://doi.org/10.1016/S1590-8658(02)80153-0
  22. Jeen YT, Kim JH. Special review-ulcerative colitis: advances in ulcerative colitis therapy. J Korean Med. 2009 ; 76(6) : 654-60.
  23. Heo J. Donguibogam. Seoul : Beobin. 2011 : 391-402.
  24. Won SG, Gung GW. Manseong-biteugiseonggweyangseong-gyeoljangyeom-jeog-jungui-yeon gu-baljeon. Hanam-jungui-hagwon-hagbo. 2004 ; 19(3) : 81-4.
  25. Song CH, Son R, Choi J. Junguiyag-chilyogweyangseong-gyeoljangyeom-imsang-bunseog. Junghwa-junguiyag-haggan. 2007 ; 25(1) : 186-7.
  26. Kim JS, Ryu BH, Park DW, Ryu KW. Enema therapy of ulcerative colitis. The Journal of Traditional Korean Medicine. 1998 ; 8(1) : 9-15.
  27. Ji HJ, Lee SI. National standard of traditional medicinal materials. Vol 3. Seoul : Korea Medical Index Company. 1988 : 463.
  28. Tao HJ. Ming yi bie lu. Beijing : Ren-min-weisheng-chu-ban-she. 1986 : 128-9.
  29. Kim HS, Berstad A. Experimental colitis in animal models. Scand J Gastroenterol. 1992 ; 27(7) : 529-37. https://doi.org/10.3109/00365529209000116
  30. Lee GH. Igongsan ameliorate DSS-induced colitis in mice. Seoul : Kyung Hee Univ. 2012. Korean.
  31. Kim SY, Ryu BH, Park JW. Effects of Samiunkyungtang on inflammation and fecal enzymes in ulcerative colitis animal model. J Korean Med. 2008 ; 29(3) : 50-62.
  32. Ok MJ, Byun JS, Park SD, Lee HI. Effects of Yijin-tang(Erchen-tang) and GamiYijin-tang(Jiaweierchen-tang) on the Gastrointestinal Functions of Rats. J Korean Med. 2002 ; 23(3) : 11-25.
  33. Heo G, Jang MW, Lim SW. The Effects of Coicis Semen Extract(CSE) on dextran sulfate sodiuminduced colitis in mice. Korean J Orient Int Med. 2012 ; 33(4) : 520-32.
  34. Kim SY, Park JW, Ryu BH. Effects of Auklandia Lappa on dextran sulfate sodium-induced murine colitis. Korean J Orient Int Med. 2013 ; 34(2) : 134-46.

Cited by

  1. The Effects of Pulsatilla Koreana NAKAI Pharmacopuncture Therapy on the Chunchu (ST25) for Dextran Sulfate Sodium-Induced Colitis in Mice vol.35, pp.1, 2018, https://doi.org/10.13045/jar.2018.00024