Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Effects of Warm Needling at GB30·GB34 on Complete Freund's Adjuvant(CFA)-induced Rheumatoid Arthritis in Rats

환도(環跳)(GB30)·양릉천(陽陵泉)(GB34) 온침(溫鍼)이 CFA로 유발된 백서의 류마티스 관절염에 미치는 영향

  • Jeong, Joo Yong (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University) ;
  • Cho, Myoung Rae (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University)
  • 정주용 (동신대학교 한의과대학 침구의학교실) ;
  • 조명래 (동신대학교 한의과대학 침구의학교실)
  • Received : 2015.05.09
  • Accepted : 2015.06.03
  • Published : 2015.06.20
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Abstract

Objectives : The purpose of this study was to investigate the effects of warm needling at $GB_{30}{\cdot}GB_{34}$ on Complete Freund's Adjuvant(CFA)-induced rheumatoid arthritis in rats. Methods : Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw. Acupuncture(AT) and warm needling(W-AT0.5, W-AT1.0) were injected at $GB_{30}{\cdot}GB_{34}$, every other day for a total of 5 times beginning on day 10 after the CFA injection. Thereafter, external shape, paw edema, serum aminotransferase and anti-inflammatory factors were assessed, and hematological and histological observations were made. Results : In paw edema volume all 3 groups(AT, W-AT0.5, W-AT1.0) showed significant decrease compared to the CFA control group. In TNF-${\alpha}$ and IL-6, all 3 groups showed significant decrease compared to CFA control group. In AST and ALT all 3 groups showed no significant change. In IL-$1{\beta}$, W-AT0.5 and W-AT1.0, groups showed significant decrease compared to the CFA control group. Leucocyte, erythrocyte and thrombocyte, all 3 groups showed no significant change. In histological observations, all 3 groups were similar to the intact group in terms of synoviocyte, cartilage lacuna and cartilage cells. Conclusions : The results suggest that warm needling at $GB_{30}{\cdot}GB_{34}$, has the effect of suppressing inflammation of CFA-induced rheumatoid arthritis in rats.

Keywords

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