한국해양바이오학회지 (Journal of Marine Bioscience and Biotechnology)

한국해양바이오학회 (The Korean Society for Marine Biotechnology)
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해조류 추출물이 섬유아세포의 증식에 미치는 영향

Cell proliferation effect of brown marine algae extracts on Mouse Fibroblast

  • 고주영 (제주대학교 해양생명과학과) ;
  • 이지혁 (제주대학교 해양생명과학과) ;
  • 김현수 (제주대학교 해양생명과학과) ;
  • 김형호 (제주대학교 해양생명과학과) ;
  • 전유진 (제주대학교 해양생명과학과)
  • Ko, Ju-Young (Department of Marine Life Sciences, Jeju National University) ;
  • Lee, Ji-Hyeok (Department of Marine Life Sciences, Jeju National University) ;
  • Kim, Hyun-Soo (Department of Marine Life Sciences, Jeju National University) ;
  • Kim, Hyung-Ho (Department of Marine Life Sciences, Jeju National University) ;
  • Jeon, You-Jin (Department of Marine Life Sciences, Jeju National University)
  • 투고 : 2015.07.06
  • 심사 : 2015.07.20
  • 발행 : 2015.06.30
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초록

We examined cell regeneration efficiency of brown marine algae living in Jeju coast for search of a novel therapeutic device with cutaneous wound healing materials. The five algae were collected and compared with epidermal growth factor (EGF) as a positive control in the assays of cell proliferation and cell migration of NIH3T3 fibroblast cells. Among the 80% methanol extracts of these brown algae, the two algal extracts from Ishige foliacea and Colpomenia bullosa showed the proliferative effects of the cells similar to the effect of EGF. Besides it was found that Colpomenia bullosa extract significantly enhanced cell migration of NIH3T3 cell. In the study, therefore, we confirmed that the Colpomenia bullosa extract improved proliferation of NIH3T3 cell and a potential candidate for cultaneous wound healing.

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참고문헌

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피인용 문헌

  1. The Effects of Marine Algal Polyphenols, Phlorotannins, on Skeletal Muscle Growth in C2C12 Muscle Cells via Smad and IGF-1 Signaling Pathways vol.19, pp.5, 2015, https://doi.org/10.3390/md19050266