Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Identification and Characterization of the Antifungal Substances of a Novel Streptomyces cavourensis NA4

  • Pan, Hua-Qi (Institute of Applied Ecology, Chinese Academy of Sciences) ;
  • Yu, Su-Ya (Institute of Applied Ecology, Chinese Academy of Sciences) ;
  • Song, Chun-Feng (Institute of Applied Ecology, Chinese Academy of Sciences) ;
  • Wang, Nan (Institute of Applied Ecology, Chinese Academy of Sciences) ;
  • Hua, Hui-Ming (Department of Natural Products Chemistry, Shenyang Pharmaceutical University) ;
  • Hu, Jiang-Chun (Institute of Applied Ecology, Chinese Academy of Sciences) ;
  • Wang, Shu-Jin (Institute of Applied Ecology, Chinese Academy of Sciences)
  • Received : 2014.07.09
  • Accepted : 2014.09.29
  • Published : 2015.03.28
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Abstract

A new actinomycete strain NA4 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antifungal activities against soilborne fungal pathogens. It was identified as Streptomyces cavourensis by morphological, physiological, and phylogenetic analyses based on its 16S rRNA gene sequence. The main antifungal components were isolated and identified from the fermentation culture as bafilomycins B1 and C1. These compounds exhibited significant antifungal activities and a broad antifungal spectrum. The results suggest that the Streptomyces cavourensis NA4 and bafilomycins B1 and C1 could be used as potential biocontrol agents for soilborne fungal diseases of plants.

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References

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