Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Myeloma-associated Amyloidosis Presenting as Orthostatic Intolerance

기립불능증으로 발현한 다발골수종과 연관된 아밀로이드증

  • Jeong, Heejeong (Department of Neurology, Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Nam, Wonsik (Department of Neurology, Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Son, Seungnam (Department of Neurology, Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Kim, Soo-Kyung (Department of Neurology, Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Kang, Heeyoung (Department of Neurology, Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Choi, Nack-Cheon (Department of Neurology, Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Kwon, Oh-Young (Department of Neurology, Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Lim, ByeongHoon (Department of Neurology, Institute of Health Science, Gyeongsang National University School of Medicine) ;
  • Park, Ki-Jong (Department of Neurology, Institute of Health Science, Gyeongsang National University School of Medicine)
  • 정희정 (경상대학교 의학전문대학원 신경과학교실, 건강과학연구원) ;
  • 남원식 (경상대학교 의학전문대학원 신경과학교실, 건강과학연구원) ;
  • 손승남 (경상대학교 의학전문대학원 신경과학교실, 건강과학연구원) ;
  • 김수경 (경상대학교 의학전문대학원 신경과학교실, 건강과학연구원) ;
  • 강희영 (경상대학교 의학전문대학원 신경과학교실, 건강과학연구원) ;
  • 최낙천 (경상대학교 의학전문대학원 신경과학교실, 건강과학연구원) ;
  • 권오영 (경상대학교 의학전문대학원 신경과학교실, 건강과학연구원) ;
  • 임병훈 (경상대학교 의학전문대학원 신경과학교실, 건강과학연구원) ;
  • 박기종 (경상대학교 의학전문대학원 신경과학교실, 건강과학연구원)
  • Received : 2014.10.21
  • Accepted : 2015.03.06
  • Published : 2015.06.30
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Abstract

Amyloidosis is a systemic disorder associated with clonal plasma cell dyscrasia. Nephrotic syndrome, congestive heart failure, autonomic and peripheral neuropathy is often associated features in amyloidosis. Early diagnosis is most important because of different prognosis by stage. The diagnosis can be delayed since symptoms of amyloidosis may vary or nonspecific. We describe a patient of myeloma-associated amyloidosis, who showed orthostatic intolerance as the first symptom of the disease.

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References

  1. Hawkins PN. Amyloidosis. Blood Rev 1995;9:135-142. https://doi.org/10.1016/S0268-960X(95)90032-2
  2. Wang AK, Fealey RD, Gehrking TL, Low PA. Patterns of neuropathy and autonomic failure in patients with amyloidosis. Mayo Clin Proc 2008;83:1226-1230. https://doi.org/10.4065/83.11.1226
  3. Duston MA, Skinner M, Anderson J, Cohen AS. Peripheral neuropathy as an early marker of AL amyloidosis. Arch Intern Med 1989;149:358-360. https://doi.org/10.1001/archinte.1989.00390020080016
  4. Low, A. P, Benarroch, E. E. Cinical autonomic disorders. In. Baltimore: Williams & Wilkins, 2008:387.
  5. Mahmood S, Palladini G, Sanchorawala V, Wechalekar A. Update on treatment of light chain amyloidosis. Haematologica 2014;99:209-221. https://doi.org/10.3324/haematol.2013.087619
  6. Kumar S, Dispenzieri A, Lacy MQ, Hayman SR, Buadi FK, Colby C, et al. Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurements. J Clin Oncol 2012;30:989-995. https://doi.org/10.1200/JCO.2011.38.5724
  7. Chan J, Sangwaiya A, Arnold J. Amyloid light-chain amyloidosis, myeloma and autonomic neuropathy. Grand Rounds 2011;11:56-59. https://doi.org/10.1102/1470-5206.2011.0014
  8. No author list. Assessment: Clinical autonomic testing report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 1996;46:873-880.