Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Sleep Disturbances in Patients with Parkinson's Disease according to Disease Severity

파킨슨병의 중증도에 따른 수면 장애

  • Lee, Su-Yun (Department of Neurology, College of Medicine, Dong-A University) ;
  • Cheon, Sang-Myung (Department of Neurology, College of Medicine, Dong-A University) ;
  • Kim, Jae Woo (Department of Neurology, College of Medicine, Dong-A University)
  • 이수윤 (동아대학교 의과대학 신경과학교실) ;
  • 천상명 (동아대학교 의과대학 신경과학교실) ;
  • 김재우 (동아대학교 의과대학 신경과학교실)
  • Received : 2014.10.23
  • Accepted : 2015.06.10
  • Published : 2015.06.30
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Abstract

Background: Sleep-related disturbances and sleep disorders are common in Parkinson's disease (PD) and have a great impact on daily life of PD patients. This study was done to find the sleep characteristics and sleep disturbing factors in PD patients according to disease severity through clinical interview and polysomnographic (PSG) study. Methods: Fifty patients with PD (22 males, age $60.6{\pm}6.4$, Hoehn and Yahr (HY) stage $2.7{\pm}1.0$) were recruited and thoroughly interviewed about their sleep. PSG was performed on the patients taking routine antiparkinsonian medications. Patients were grouped into mild and moderate/severe group according to HY stage, and the results were compared between each group. Results: Ninety-four percent of total patients had one or more sleep-related disturbances based on the interview or PSG. On interview, the moderate/severe group complained more insomnia and REM sleep behavior disorder (RBD) than mild group. In PSG findings, the moderate/severe group showed lower sleep efficiency, longer sleep latency, REM sleep latency, waking time after sleep onset, and higher prevalence of RBD. Conclusions: In this study, most patients with PD had sleep disturbances. Clinical interview and PSG findings revealed deterioration of sleep quality along the disease severity. Our results suggest that sleep disturbances in PD patients are prevalent and warrant clinical attention, especially to the patients with advanced disease.

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References

  1. Chaudhuri KR, Healy DG, Schapira AH, National Institute for Clinical Excellence. Non-motor symptoms of parkinson's disease: Diagnosis and management. Lancet Neurol 2006;5:235-245. https://doi.org/10.1016/S1474-4422(06)70373-8
  2. Poewe W. Non-motor symptoms in parkinson's disease. Eur J Neurol 2008;15:14-20. https://doi.org/10.1111/j.1468-1331.2008.02056.x
  3. Lees AJ, Blackburn NA, Campbell VL. The nighttime problems of parkinson's disease. Clin Neuropharmacol 1988;11:512-519. https://doi.org/10.1097/00002826-198812000-00004
  4. Ahn TB, Jeon BS. Sleep disturbance and sleep-related disorders in parkinson’s disease. J Korean Neurol Assoc 2002;20:365-372.
  5. Tandberg E, Larsen JP, Karlsen K. Excessive daytime sleepiness and sleep benefit in parkinson's disease: A community-based study. Mov Disord 1999;14:922-927. https://doi.org/10.1002/1531-8257(199911)14:6<922::AID-MDS1003>3.0.CO;2-7
  6. Suzuki K, Miyamoto M, Miyamoto T, Iwanami M, Hirata K. Sleep disturbances associated with parkinson's disease. Parkinsons Dis 2011;2011:219056.
  7. Kumar S, Bhatia M, Behari M. Sleep disorders in parkinson's disease. Mov Disord 2002;17:775-781. https://doi.org/10.1002/mds.10167
  8. Kim HS, Kang JH, Park MJ, Cheon SM, Park KW, Cha JK, et al. Clinical characteristics of sleep disorders in parkinson's disease. J Korean Neurol Assoc 2008;20:365-372.
  9. Comella CL. Sleep disturbances and excessive daytime sleepiness in parkinson disease: An overview. J Neural Transm Suppl 2006;70:349-355. https://doi.org/10.1007/978-3-211-45295-0_53
  10. Peeraully T, Yong MH, Chokroverty S, Tan EK. Sleep and parkinson's disease: A review of case-control polysomnography studies. Mov Disord 2012;27:1729-1737. https://doi.org/10.1002/mds.25197
  11. Trenkwalder C, Arnulf I. Chapter 87 - parkinsonism. In: Dement MHKRC. Principles and Practice of Sleep Medicine (Fifth Edition). Philadelphia: W.B. Saunders. 2011;980-992.
  12. Hughes AJ, Ben-Shlomo Y, Daniel SE, Lees AJ. What features improve the accuracy of clinical diagnosis in parkinson's disease: A clinicopathologic study. 1992. Neurology 2001;57 (10 Suppl 3):S34-38.
  13. Iber C, Ancoli-Israel S, Chesson A, Quan SF for American Academy of Sleep Medicine. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications. 1st ed. Westchester, Ill: American Academy of Sleep Medicine; 2007.
  14. American Academy of Sleep Medicine. International Classification of sleep disorders: diagnostic and coding manual. 2nd ed. Westchester, Ill: American Academy of Sleep Medicine; 2005.
  15. Suzuki K, Okuma Y, Hattori N, Kamei S, Yoshii F, Utsumi H, et al. Characteristics of sleep disturbances in japanese patients with parkinson's disease. A study using parkinson's disease sleep scale. Mov Disord 2007;22:1245-1251. https://doi.org/10.1002/mds.21257
  16. Happe S, Klösch G, Lorenzo J, Kunz D, Penzel T, Roschke J, et al. Perception of sleep: Subjective versus objective sleep parameters in patients with parkinson's disease in comparison with healthy elderly controls. J Neurol 2005;252:936-943. https://doi.org/10.1007/s00415-005-0785-0
  17. Yong MH, Fook-Chong S, Pavanni R, Lim LL, Tan EK. Case control polysomnographic studies of sleep disorders in parkinson's disease. PLoS One 2011;6:e22511. https://doi.org/10.1371/journal.pone.0022511
  18. Diederich NJ, Vaillant M, Mancuso G, Lyen P, Tiete J. Progressive sleep 'destructuring' in parkinson's disease. A polysomnographic study in 46 patients. Sleep Med 2005;6:313-318. https://doi.org/10.1016/j.sleep.2005.03.011
  19. Norlinah MI, Afidah KN, Noradina AT, Shamsul AS, Hamidon BB, Sahathevan R, et al. Sleep disturbances in malaysian patients with parkinson's disease using polysomnography and PDSS. Parkinsonism Relat Disord 2009;15:670-674. https://doi.org/10.1016/j.parkreldis.2009.02.012
  20. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol 2013;177:1006-1014. https://doi.org/10.1093/aje/kws342
  21. Apps MC, Sheaff PC, Ingram DA, Kennard C, Empey DW. Respiration and sleep in parkinson's disease. J Neurol Neurosurg Psychiatry 1985;48:1240-1245. https://doi.org/10.1136/jnnp.48.12.1240
  22. Shpirer I, Miniovitz A, Klein C, Goldstein R, Prokhorov T, Theitler J, et al. Excessive daytime sleepiness in patients with parkinson's disease: A polysomnography study. Mov Disord 2006;21:1432-1438. https://doi.org/10.1002/mds.21002
  23. Cochen De Cock V, Abouda M, Leu S, Oudiette D, Roze E, Vidailhet M, et al. Is obstructive sleep apnea a problem in parkinson's disease? Sleep Med 2010;11:247-252. https://doi.org/10.1016/j.sleep.2009.05.008
  24. Maria B, Sophia S, Michalis M, Charalampos L, Andreas P, John ME, et al. Sleep breathing disorders in patients with idiopathic parkinson's disease. Respir Med 2003;97:1151-1157. https://doi.org/10.1016/S0954-6111(03)00188-4
  25. Diederich NJ, Vaillant M, Leischen M, Mancuso G, Golinval S, Nati R, et al. Sleep apnea syndrome in parkinson's disease. A case-control study in 49 patients. Mov Disord 2005;20:1413-1418. https://doi.org/10.1002/mds.20624
  26. Gagnon JF, Vendette M, Postuma RB, Desjardins C, Massicotte- Marquez J, Panisset M, et al. Mild cognitive impairment in rapid eye movement sleep behavior disorder and parkinson's disease. Ann Neurol 2009;66:39-47. https://doi.org/10.1002/ana.21680
  27. Postuma RB, Bertrand JA, Montplaisir J, Desjardins C, Vendette M, Rios Romenets S, et al. Rapid eye movement sleep behavior disorder and risk of dementia in parkinson's disease: A prospective study. Mov Disord 2012;27:720-726. https://doi.org/10.1002/mds.24939