Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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The Improvement Effects of β-Glucan on Adiposity and Serum Lipids Levels in High Fat Diet-Induced Obese Rats

베타-글루칸의 고지방 식이 유도 비만쥐에서 체지방 및 혈청지질 개선효과

  • Hong, Kyung Hee (Dept. of Food Science and Nutrition, Dongseo University) ;
  • Kim, Hyun-Soon (Dept. of Conversing Technology, Graduate School of Venture, Hoseo University) ;
  • Jang, Ki-Hyo (Dept. of Food and Nutrition, Kangwon University) ;
  • Kang, Soon Ah (Dept. of Conversing Technology, Graduate School of Venture, Hoseo University)
  • 홍경희 (동서대학교 식품영양학과) ;
  • 김현순 (호서대학교 벤처대학원 융합공학과) ;
  • 장기효 (강원대학교 식품영양학과) ;
  • 강순아 (호서대학교 벤처대학원 융합공학과)
  • Received : 2015.03.03
  • Accepted : 2015.06.11
  • Published : 2015.06.30
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Abstract

This study was aimed to investigate the effect of dietary ${\beta}$-glucan obtained from bacterial fermentation on the adiposity and serum lipids level in rats. Sprague-Dawley rats fed high fat diet for 6 weeks to induce obesity, and subsequently fed with 0% (high fat control group), 0.1% or 0.5% ${\beta}$-glucan supplemented high-fat diets (w/w) for another 5 weeks. For comparison, normal control groups fed AIN-76A diet. Supplemented with 0.1% ${\beta}$-glucan resulted in a significant reduction of high-fat induced peritoneal fat and visceral fat development by 16%, 19%, and 28%, respectively(P<0.05). Serum free fatty acid levels were reduced(by 19%), whereas the HDL cholesterol level was increased(by 50%) by 0.1% dietary ${\beta}$-glucan(P<0.05). In conclusion, dietary ${\beta}$-glucan reduced adiposity and improved serum lipids in obese rats fed high fat diet. The present study suggest that ${\beta}$-glucan supplementation to the diet is beneficial in suppressing diet-induced obesity and dyslipidemia.

본 연구는 미생물 유래 베타-글루칸의 항비만 효과를 검증하기 위하여 동물실험을 통해 식이 베타-글루칸이 체지방 형성과 혈중 지질에 미치는 영향을 조사하였다. Sprague-Dawley종 흰쥐를 6주간 고지방 식이로 사육하여 비만을 유도한 후 베타-글루칸을 각각 식이 무게의 0%(고지방 대조군), 0.1%, 0.5%로 함유한 식이로 5주간 사육하였다. 정상 대조군은 AIN-76A 식이로 사육하였다. 고지방식이군에서 단위체중당 체지방이 많았으며, 0.1% 베타-글루칸 공급은 고지방 식이에 의해 유도된 복막지방, 내장지방 축적을 각각 16%와 19% 억제하였고, 혈중 렙틴을 28% 감소시켰다(P<0.05). 정상 대조군과 비교하여 고지방 대조군의 평균 지방세포 크기는 1.7배 높았으며, 베타-글루칸 섭취군에서는 감소하여 정상대조군 수준으로 낮아졌다(P<0.05). 0.1% 베타-글루칸 섭취에 의해 혈청 유리지방산 농도는 19% 감소하였고, 반면 HDL 콜레스테롤 50% 증가하였다(P<0.05). 결론적으로 베타-글루칸 공급은 렙틴과 같은 호르몬 분비와 지단백질 대사 변화로 지질 대사 개선을 유도하고 체지방 형성과 축적을 억제하는 것으로 보인다. 본 연구 결과 베타-글루칸은 고지방 식사에 기인하는 비만과 이상지혈증 개선에 도움이 되는 기능성 식품 소재로 사용될 수 있을 것으로 사료된다.

Keywords

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