Economic and Environmental Geology (자원환경지질)

The Korean Society of Economic and Environmental Geology (대한자원환경지질학회)
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Development of Antibiotic-intercalated Smectite Composites and Its Drug Delivery Potential in Gastric System

항생제-스멕타이트 복합물 유도 및 소화기계 약물전달체로의 가능성

  • Song, Yungoo (Department of Earth System Sciences, Yonsei University) ;
  • Chung, Donghoon (Department of Earth System Sciences, Yonsei University) ;
  • Song, Young Goo (Division of Infectious Diseases, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Choi, Woohyun (Department of Earth System Sciences, Yonsei University)
  • 송윤구 (연세대학교 지구시스템과학과) ;
  • 정동훈 (연세대학교 지구시스템과학과) ;
  • 송영구 (강남세브란스병원 감염내과, 연세대학교 의과대학 내과학교실) ;
  • 최우현 (연세대학교 지구시스템과학과)
  • Received : 2015.06.26
  • Accepted : 2015.06.29
  • Published : 2015.06.28
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Abstract

In this study, we aimed to make antibiotic-intercalated smectite composites using amoxicillin and clarithromycin as hygroscopic antibiotics, and gentamicin, tobramycin and netilmicin as non-hygroscopic aminoglucosides, and to check their drug delivery potential in gastric system using preliminary in-situ column release test for clarithromycinsmectite composite. All antibiotics were successfully intercalated into the interlayer of smectite by cation-exchange reaction in the batch experiment. Equilibrium batch test showed that clarithromycin-intercalation followed Langmuir isotherm and the possible maximum amount was calculated as 1.811 mmole/g. Clarithromycin was continuously released by the solutions of pH=2, 3, and 4 and the amount was decreased with pH increase.

본 연구에서는 흡수성 항생제인 Amoxicillin과 Clarithromycin, 그리고 아미노글루코사이드 (Aminoglucoside) 계열 비흡수성 항생제인 Gentamicin, Tobramycin 및 Netilmicin의 스멕타이트 층간 유도를 통해 항생제-스멕타이트 복합물을 합성하고, 이 중 Clarithromycin-스멕타이트 복합물 대상 예비 용출실험을 통해 소화기계 항생제 약물전달체로의 가능성을 확인하고자 하였다. 실험 결과, 5종의 항생제 모두 수용액 상태에서의 교환반을을 통해 스멕타이트 층간에 유도되었다. Clarithromycin에 대하여 스멕타이트 층간 최대 유도 량을 결정하기 위한 농도별 평형반응실험 결과 Langmuir isotherm을 따르며, 층간 최대유도 량은 1.811 mmole/g으로 계산되었다. Clarithromycin-스멕타이트 복합물 대상 pH=2, 3 및 4 용출용액을 이용한 예비 용출실험결과 모든 용출용액에서 지속적인 용출이 일어났으며, pH 증가에 따라 용출량은 감소하였다.

Keywords

References

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