Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Insulin-like Growth Factor-1 (IGF-1) Gene Expression Is Enhanced under Hypothermia but Depressed under Additional Ischemic Stimulus

  • Kwon, O-Yu (Department of Anatomy, College of Medicine, Chungnam National University) ;
  • Kwon, Kisang (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University) ;
  • Yu, Kweon (Korea Research Institute of Bioscience & Biotechnology) ;
  • Kim, Seung-Whan (Department of Emergency Medicine, College of Medicine, Chungnam National University)
  • Received : 2015.03.13
  • Accepted : 2015.05.07
  • Published : 2015.06.30
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Abstract

There are several studies that show hypothermia improves cellular ischemia damages on experimental and clinical bases. However, its exact molecular mechanisms are unclear. In this study, we demonstrate that hypothermia induced insulin-like growth factor 1 (IGF1) gene expression, and its expression was dramatically decreased under ischemic insults. It was also demonstrated that hypothermia activated endoplasmic reticulum (ER) stress sensors especially both the phosphorylation of $eIF2{\alpha}$ (eukaryotic translation initiation factor 2 alpha) and ATF6 (activating transcription factor-6) proteolytic cleavage. However, the factors of apoptosis and autophagy were not associated with hypothermia. We suggest that hypothermia-treated IGF1 gene expression after ischemia may show a good possibility for the development of treatments and diagnostic methods in cerebral ischemic damages.

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References

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