Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Effects of Rice Bran Extracts Fermented with Lactobacillus plantarum on Neuroprotection and Cognitive Improvement in a Rat Model of Ischemic Brain Injury

  • Hong, Jeong Hwa (Department of Smart Foods and Drugs, Inje University) ;
  • Kim, Ji Yeong (Department of Biological Sciences, Institute of Basic Science, Inje University) ;
  • Baek, Seung Eun (Department of Biological Sciences, Institute of Basic Science, Inje University) ;
  • Ingkasupart, Pajaree (Department of Smart Foods and Drugs, Inje University) ;
  • Park, Hwa Jin (Department of Biomedical Laboratory Science, Inje University) ;
  • Kang, Sung Goo (Department of Biological Sciences, Institute of Basic Science, Inje University)
  • Received : 2015.04.22
  • Accepted : 2015.05.28
  • Published : 2015.06.30
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Abstract

This work aimed to study whether rice bran extract fermented with Lactobacillus plantarum (LW) promotes functional recovery and reduces cognitive impairment after ischemic brain injury. Ischemic brain injury was induced by middle cerebral artery occlusion (MCAO) in rats. Four groups were studied, namely the (1) sham, (2) vehicle, (3) donepezil, and (4) LW groups. Animals were injected with LW once a day for 7 days after middle cerebral artery occlusion. LW group showed significantly improved neurological function as compared to the vehicle group, as well as enhanced learning and memory in the Morris water maze. The LW group showed the greatest functional recovery. Moreover, the LW group showed an enhanced more survival cells anti-apoptotic effect in the cortex and neural cell densities in the hippocampal DG and CA1. In addition, this group showed enhanced expression of neurotrophic factors, antioxidant genes, and the acetylcholine receptor gene, as well as synaptophysin (SYP), Fox-3 (NeuN), doublecortin (DCX), and choline acetyltransferase (ChAT) proteins. Our findings indicate that LW treatment showed the largest effects in functional recovery and cognitive improvement after ischemic brain injury through stimulation of the acetylcholine receptor, antioxidant genes, neurotrophic factors, and expression of NeuN, SYP, DCX, and ChAT.

Keywords

References

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