Biomolecules & Therapeutics

  • 제23권4호
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  • Pages.374-378
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  • 2015
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
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Effects of Resveratrol Supplementation on Oxidative Damage and Lipid Peroxidation Induced by Strenuous Exercise in Rats

  • 투고 : 2015.01.26
  • 심사 : 2015.04.27
  • 발행 : 2015.07.01
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초록

The purpose of the present study was to investigate the effects of resveratrol supplementation on oxidative damage and lipid peroxidation induced by strenuous exercise in rats. The rats were randomly divided into five groups: a sedentary control group, an exercise control group, and three treatment exercise groups administered increasing doses of resveratrol (25, 50, and 100 mg/kg body weight). Resveratrol was administered by oral gavage once daily for four weeks. At the end of the four-week period, the rats performed a strenuous exercise on the treadmill, and the levels of lactate dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured. The results showed that resveratrol supplementation had protective effects against strenuous exercise-induced oxidative damage and lipid peroxidation by lowering the levels of LDH, CK, MDA, 4-HNE, and 8-OHdG in the serum or muscle of rats. These beneficial effects are probably owing to the inherent antioxidant activities of resveratrol.

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참고문헌

  1. Aguilo, A., Tauler, P., Fuentespina, E., Tur, J. A., Cordova, A. and Pons, A. (2005) Antioxidant response to oxidative stress induced by exhaustive exercise. Physiol. Behav. 84, 1-7. https://doi.org/10.1016/j.physbeh.2004.07.034
  2. Belviranl, M., Gokbel, H., Okudan, N. and Basaral, K. (2012) Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats. Br. J. Nutr. 108, 249-256. https://doi.org/10.1017/S0007114511005496
  3. Browning, J. D. and Horton, J. D. (2004) Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 114, 147-152. https://doi.org/10.1172/JCI200422422
  4. Ceci, R., Duranti, G., Sgro, P., Sansone, M., Guidetti, L., Baldari, C., Sabatini, S. and Di Luigi, L. (2015) Effects of tadalafil administration on plasma markers of exercise-induced muscle damage, IL6 and antioxidant status capacity. Eur. J. Appl. Physiol. 115, 531-539. https://doi.org/10.1007/s00421-014-3040-5
  5. Gehm, B. D., McAndrews, J. M., Chien, P. Y. and Jameson, J. L. (1997) Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. U.S. A. 94, 14138-14143. https://doi.org/10.1073/pnas.94.25.14138
  6. Ji, L. L. (1995) Oxidative stress during exercise: implication of antioxidant nutrients. Free Radic. Biol. Med. 18, 1079-1086. https://doi.org/10.1016/0891-5849(94)00212-3
  7. Joe, A. K., Liu, H., Suzui, M., Vural, M. E., Xiao, D. and Weinstein, I. B. (2002) Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin. Cancer Res. 8, 893-903.
  8. Kumar, K. V. and Naidu, M. U. R. (2002) Effect of oral melatonin on exercise-induced oxidant stress in healthy subjects. Indian J. Pharmacol. 34, 256-259.
  9. Lu, H. K., Hsieh, C. C., Hsu, J. J., Yang, Y. K. and Chou, H. N. (2006) Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress. Eur. J. Appl. Physiol. 98, 220-226. https://doi.org/10.1007/s00421-006-0263-0
  10. Misra, D. S., Maiti, R. and Ghosh, D. (2009) Protection of swimming-induced oxidative stress in some vital organs by the treatment of composite extract of Withania somnifera, Ocimum sanctum and Zingiber officinalis in male rat. Afr. J. Tradit. Complement. Altern. Med. 6, 534-543.
  11. Morillas-Ruiz, J., Zafrilla, P., Almar, M., Cuevas, M. J., Lopez, F. J., Abellan, P., Villegas, J. A. and Gonzalez-Gallego, J. (2005) The effects of an antioxidant-supplemented beverage on exercise-induced oxidative stress: results from a placebo-controlled doubleblind study in cyclists. Eur. J. Appl. Physiol. 95, 543-549. https://doi.org/10.1007/s00421-005-0017-4
  12. Nosal', R., Drabikova, K., Jancinova, V., Perecko, T., Ambrozova, G., Ciz, M., Lojek, A., Pekarova, M., Smidrkal, J. and Harmatha, J. (2014) On the molecular pharmacology of resveratrol on oxidative burst inhibition in professional phagocytes. Oxid. Med. Cell. Longev. 2014, 706269.
  13. Ostman, B., Sjodin, A., Michaelsson, K. and Byberg, L. (2012) Coenzyme Q10 supplementation and exercise-induced oxidative stress in humans. Nutrition 28, 403-417. https://doi.org/10.1016/j.nut.2011.07.010
  14. Perluigi, M., Coccia, R. and Butterfield, D. A. (2012) 4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies. Antioxid. Redox Signal. 17, 1590-1609. https://doi.org/10.1089/ars.2011.4406
  15. Qi, B., Zhang, L., Zhang, Z., Ouyang, J. and Huang, H. (2014) Effects of ginsenosides-Rb1 on exercise-induced oxidative stress in forced swimming mice. Pharmacogn. Mag. 10, 458-463. https://doi.org/10.4103/0973-1296.141818
  16. Rahimi, R. (2011) Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise. J. Strength Cond. Res. 25, 3448-3455. https://doi.org/10.1519/JSC.0b013e3182162f2b
  17. Sacheck, J. M. and Blumberg, J. B. (2001) Role of vitamin E and oxidative stress in exercise. Nutrition 17, 809-814. https://doi.org/10.1016/S0899-9007(01)00639-6
  18. Sampey, B. P., Korourian, S., Ronis, M. J., Badger, T. M. and Petersen, D. R. (2003) Immunohistochemical characterization of hepatic malondialdehyde and 4-hydroxynonenal modified proteins during early stages of ethanol-induced liver injury. Alcohol. Clin. Exp. Res. 27, 1015-1022. https://doi.org/10.1111/j.1530-0277.2003.tb04430.x
  19. Sato, T., Takeda, H., Otake, S., Yokozawa, J., Nishise, S., Fujishima, S., Orii, T., Fukui, T., Takano, J., Sasaki, Y., Nagino, K., Iwano, D., Yaoita, T. and Kawata, S. (2010) Increased plasma levels of 8-hydroxydeoxyguanosine are associated with development of colorectal tumors. J. Clin. Biochem. Nutr. 47, 59-63. https://doi.org/10.3164/jcbn.10-12
  20. Shan, X., Zhou, J., Ma, T. and Chai, Q. (2011) Lycium barbarum polysaccharides reduce exercise-induced oxidative stress. Int. J. Mol. Sci. 12, 1081-1088. https://doi.org/10.3390/ijms12021081
  21. Singh, C. K., Ndiaye, M. A. and Ahmad, N. (2015) Resveratrol and cancer: Challenges for clinical translation. Biochim. Biophys. Acta 1852, 1178-1185. https://doi.org/10.1016/j.bbadis.2014.11.004
  22. Stivala, L. A., Savio, M., Carafoli, F., Perucca, P., Bianchi, L., Maga, G., Forti, L., Pagnoni, U. M., Albini, A., Prosperi, E. and Vannini, V. (2001) Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. J. Biol. Chem. 276, 22586-22594. https://doi.org/10.1074/jbc.M101846200
  23. Tauler, P., Sureda, A., Cases, N., Aguilo, A., Rodriguez-Marroyo, J. A., Villa, G., Tur, J. A. and Pons, A. (2006) Increased lymphocyte antioxidant defences in response to exhaustive exercise do not prevent oxidative damage. J. Nutr. Biochem. 17, 665-671. https://doi.org/10.1016/j.jnutbio.2005.10.013
  24. Xie, H. C., Han, H. P., Chen, Z. and He, J. P. (2013) A study on the effect of resveratrol on lipid metabolism in hyperlipidemic mice. Afr. J. Tradit. Complement. Altern. Med. 11, 209-212.
  25. You, L. J., Zhao, M. M., Regenstein, J. M. and Ren, J. Y. (2011) In vitro antioxidant activity and in vivo anti-fatigue effect of loach (Misgurnus anguillicaudatus) peptides prepared by papain digestion. Food Chem. 124, 188-194. https://doi.org/10.1016/j.foodchem.2010.06.007

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