References
- Abedi, H., and Zachary, I. (1997). Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J. Bio. Chem. 272, 15442-15451. https://doi.org/10.1074/jbc.272.24.15442
- Bardos, J.I. and Ashcroft, J. (2005). Negative and positive regulation of HIF-1: a complex network. Biochimica et Biophysica Acta 1755, 107-120.
- Cabrita, M.A., Jones, L.M., Quizi, J.L., Sabourin, L.A., Makay, B.C., and Addison, C.L. (2011). Focal adhesion kinase inhibitors are potent anti-angiogenic agents. Mol. Oncol. 5, 517-526. https://doi.org/10.1016/j.molonc.2011.10.004
-
Carroll, V.A., and Ashcroft, M. (2008). Role of hypoxia-inducible factor (HIF
$1\alpha$ versus HIF-$2\alpha$ in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von hippel-lindau function: implications for targeting the HIF pathway. Cancer Res. 15, 6264-6270. - Chang, Y., Zhang, X., Horton, J.R., Upadhyay, A.K., Spannhoff, A., Liu, J., Snyder, J.P., Bedford, M.T., and Cheng, X. (2009). Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat. Struct. Mol. Biol. 16. 312-317. https://doi.org/10.1038/nsmb.1560
- Chen, M.W., Hua, K.T., Kao, H.J., Chi, C.C., Wei, L.H., Johansson, G., Shiah, S.G., Chen, P.S., Jeon, Y.M, Cheng, T.Y., et al. (2010). H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res. 70, 7830-7840. https://doi.org/10.1158/0008-5472.CAN-10-0833
- Choi, J.H., Nguyen, M.P., Lee, D., Oh, G.T., and Lee, Y.M. (2014). Hypoxia-induced endothelial progenitor cell function is blunted in angiotensinogen knockout mice. Mol. Cells 37, 487-496. https://doi.org/10.14348/molcells.2014.0119
- Ellis, L., Hammers, H., and Pili, R. (2009). Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett. 280, 145-153. https://doi.org/10.1016/j.canlet.2008.11.012
- Forsythe, J.A., Jiang, B.H., Iyer, N.V., Agani, F., Leung, S.W., Koos, R.D., and Semenza, G.L. (1996). Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, 4604-4613. https://doi.org/10.1128/MCB.16.9.4604
- German, A.E., Mammoto, T., Jiang, E., Ingber, D.E., and Mammoto, A. (2014). Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression. J. Cell Sci. 127, 1672-1683. https://doi.org/10.1242/jcs.132316
- Hatzimichael, E., Dasoula, A., Shah, R., Syed, N., Papoudou-Bai, A., Coley, H.M., Dranitasris, G., Bourantas, K.L., Stebbing, J., and Crook, T. (2010). The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia. Eur. J. Haematol. 84, 47-51. https://doi.org/10.1111/j.1600-0609.2009.01344.x
- Karagiannis, E.D., and Popel, A.S. (2006). Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model. J. Theor. Biol. 238, 124-145. https://doi.org/10.1016/j.jtbi.2005.05.020
- Ke, Q., and Costa, M. (2006). Hypoxia-inducible factor-1 (HIF-1). Mol. Pharm. 70, 1469-1480. https://doi.org/10.1124/mol.106.027029
- Kim, Y., Kim, Y.S., Kim, D.E., Lee, J.S., Song, J.H., Kim, H.G., Cho, D.H., Jeong, S.Y., Jin, D.H., Jang, S.J. et al. (2013). BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production. Autophagy 9, 2126-2139. https://doi.org/10.4161/auto.26308
- Kiselyov, A., Balakin, K.V., and Tkachenko, S.E. (2007). VEGF/VEGFR signaling as a target for inhibiting angiogenesis. Pepert. Pion. Investig. Drugs 16, 83-107.
- Kuljaca, S., Liu, T., Tee, A.E.L., Haber, M. Norris, Dwarte, G.M., and Marshall, M.D.T. (2007). Enhancing the anti-angiogenic action of histone deacetylase inhibitors. Mol. Cancer 6, 1-11.
- Law, A.Y., Lai, K.P., Ip, C.K., Wong, A.S., Wagner, G.F., and Wong, C.K. (2008). Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells. Exp. Cell Res. 314, 1823-1830. https://doi.org/10.1016/j.yexcr.2008.03.001
- Lee, J.S., Kim, Y., Kim, I.S., Kim, B., Choi, H.J., Lee, J.M., Shin, H.J., Kim, J.H., Kim, J.Y., Seo, S.B., et al. (2010). Negative regulation of hypoxic responses via induced reptin methylation. Mol. Cell 39, 71-85. https://doi.org/10.1016/j.molcel.2010.06.008
- Lee, J.S., Kim, Y., Bhin, J., Shin, H.J., Nam, H.J., Lee, S.H., Yoon, J.B., Binda, O., Gozani, O., Hwang, D., et al. (2011). Hypoxiainduced methylation of a pontin chromatin remodeling factor. Proc. Natl. Acad. Sci. USA 108, 13510-13515. https://doi.org/10.1073/pnas.1106106108
- Lu, C., Han, H.D., Mangala, L.S., Ali-Fehmi, R., Newton, C.S., Ozbun, L., Armaiz-Pena, G.N., Hu, W., Stone, R.L., Munkarah, A., et al. (2010). Regulation of tumor angiogenesis by EZH2. Cancer Cell 18, 185-197. https://doi.org/10.1016/j.ccr.2010.06.016
- Lu, Z., Tian, Y. Salwen, H.R., Chlenski, A., Godley, L.A., Raj, J.U., and Yang, Q. (2013). Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells. Anti-Cancer Drugs 24, 484-493. https://doi.org/10.1097/CAD.0b013e32835ffdbb
- Ma, N. (2011). HIF-1 is the commander of gateways to cancer. Nagy J. Cancer Sci. Ther. 3, 35-40.
- Mamahon, G. (2000). VEGF receptor signaling in tumor angiogenesis. Oncologist 5, 3-10. https://doi.org/10.1634/theoncologist.5-suppl_1-3
- Nguyen, M.P., Lee, S., and Lee, Y.M. (2013). Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics. Arch. Pharm. Res. 36, 252-263. https://doi.org/10.1007/s12272-013-0058-x
- Rundhaug, J.E. (2003). Matrix metalloproteinases, angiogenesis, and cancer. Clin. Cancer Res. 9, 551-554.
- Schaller, M.D. (2001). Paxillin: a focal adhesion-associated adaptor protein. Oncogene 20, 6459-6472. https://doi.org/10.1038/sj.onc.1204786
- Sigalotti, L., Fratta, E., Coral, S., and Maio, M. (2014). Epigenetic drugs as immunomodulators for combination therapies in solid tumors. Pharmacol. Ther. 142, 339-350. https://doi.org/10.1016/j.pharmthera.2013.12.015
- Stroka, D.M., Burkhardt, T., Desbaillets, I., Wenger, R.H., Neil, D.A.H., Bauer, C., Gassmann, M., and Caninas, D. (2001). HIF- 1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J. 15, 2445-2453. https://doi.org/10.1096/fj.01-0125com
- Tavora, B., Batista, S., Reynolds, L.E., Jadeja, S., Robinson, S., Kostourou, V., Hart, I., Fruttiger, M., Parsons, M., and Hodivala-Dilke, K.M. (2010). Endothelial FAK is required for tumour angiogenesis. EMBO Mol. Med. 2, 516-52840. https://doi.org/10.1002/emmm.201000106
- Tong, Z., Qing, Y., Wu, Y., Hu, X., Jiang, L., and Wu, X. (2014). Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways. Toxicol. Appl. Pharmacol. 281, 166-173. https://doi.org/10.1016/j.taap.2014.07.026
- Varier, R.A., and Timmers, H.T.M. (2011). Histone lysine methylation and demethylation pathways in cancer. Biochim. Biophys. Acta 1815, 75-89.
- Wang, L., Zhang, Z.G., Zhang, R.L., Gregg, S.R., Hozeska-Solgot, A., Tourneau, Y.L., Wang, Y., and Chopp, M. (2006). Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin- activated endothelial cells promote neural progenitor cell migration. N. Neurosci. 26, 5996-6003. https://doi.org/10.1523/JNEUROSCI.5380-05.2006
- Watson, J.A., Watson, C.J., McCann, A., and Baugh, J. (2010). Epigenetics, the epicenter of the hypoxic response. Epigenetics 5, 293-296. https://doi.org/10.4161/epi.5.4.11684
- Xu, W.S., Parmigiani, R.B., and Marks, P.A. (2007). Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 26, 5541-5552. https://doi.org/10.1038/sj.onc.1210620
- Yee, K.M., Spivak-Kroizman, T.R. and Powis, G. (2008). HIF-1 regulation: not so easy come, easy go. Trends Biochem. Sci. 33, 526-534. https://doi.org/10.1016/j.tibs.2008.08.002
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