대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제36권1호
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  • Pages.16-21
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  • 2015
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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수술현미경용 다중형광 관측 시스템 연구

Development of Indocyanine Green and 5-Aminolevulinic Acid Detection System for Surgical Microscope

  • 김홍래 (국립암센터 융합기술연구부 의공학연구과) ;
  • 이현민 (국립암센터 융합기술연구부 의공학연구과) ;
  • 윤웅배 (국립암센터 융합기술연구부 의공학연구과) ;
  • 김영재 (국립암센터 융합기술연구부 의공학연구과) ;
  • 김석기 (국립암센터 융합기술연구부 분자영상치료연구과) ;
  • 유헌 (국립암센터 이행성 임상 제 2연구부 특수암연구과) ;
  • 주재영 (한국광기술원 신조명연구본부 스마트조명연구센터) ;
  • 김광기 (국립암센터 융합기술연구부 의공학연구과) ;
  • 이승훈 (국립암센터 이행성 임상 제 2연구부 특수암연구과)
  • Kim, Hong Rae (Biomedical Engineering Branch, Division of Convergence Technology, National Cancer Center) ;
  • Lee, Hyun Min (Biomedical Engineering Branch, Division of Convergence Technology, National Cancer Center) ;
  • Yoon, Woong Bae (Biomedical Engineering Branch, Division of Convergence Technology, National Cancer Center) ;
  • Kim, Young Jae (Biomedical Engineering Branch, Division of Convergence Technology, National Cancer Center) ;
  • Kim, Seok Ki (Molecular Imaging & Therapy Branch, National Cancer Center) ;
  • Yoo, Heon (Pediatric Oncology Branch & Hospital, National Cancer Center) ;
  • Joo, Jae Young (Lighting Technology Team, Korea Photonics Technology Institute) ;
  • Kim, Kwang Gi (Biomedical Engineering Branch, Division of Convergence Technology, National Cancer Center) ;
  • Lee, Seung-Hoon (Pediatric Oncology Branch & Hospital, National Cancer Center)
  • 투고 : 2014.10.05
  • 심사 : 2014.12.24
  • 발행 : 2015.02.28
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초록

Indocyanine green(ICG) and 5-aminolevulinic acid(5-ALA) have been widely used to mark blood vessels or tumors. However, fluorescent dye detection systems were designed to use one type of dyes only. In this study, we proposed a detection system capable of detecting Indocyanine green and 5-aminolevulinic acid. Multiple filters and light sources are integrated into a single system. In this study, we performed analysis of fluorescent dyes and configured a detection system. During the analysis, it was found that Indocyanine green and 5-aminolevulinic acid have the maximum intensity at $40{\mu}M$. We designed light source for fluorescent dyes and conducted compatibility test using a commercial surgical microscope. The fluorescent dye detection system was configured based on the experimental results. The developed system successfully detects Indocyanine green and 5-aminolevulinic acid. Therefore, more efficient surgical operations can be achieved using both fluorescent dyes at the same time. We expect that the developed system can increase the survival rate of patients.

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참고문헌

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