Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Development of Mono Layer Cell Adsorption Apparatus to Create a Slide for Microscopic Diagnosis

현미경 진단용 슬라이드 제작을 위한 단층세포 흡착장치 개발

  • Oh, H.Y. (Department of Healthcare Engineering, Chonbuk National University) ;
  • Mun, M.G. (Department of Healthcare Engineering, Chonbuk National University) ;
  • Kim, S.H. (Division of Biomedical Engineering, Chonbuk National University) ;
  • Kim, D.W. (Division of Biomedical Engineering, Chonbuk National University) ;
  • Kang, S.M. (PathTech co.) ;
  • Sung, R.G. (PathTech co.) ;
  • Kim, H.C. (PathTech co.)
  • 오한영 (전북대학교 공과대학 헬스케어공학과) ;
  • 문민기 (전북대학교 공과대학 헬스케어공학과) ;
  • 김성현 (전북대학교 공과대학 바이오메디컬공학부) ;
  • 김동욱 (전북대학교 공과대학 바이오메디컬공학부) ;
  • 강소미 ((주)패스텍) ;
  • 성락경 ((주)패스텍) ;
  • 김현창 ((주)패스텍)
  • Received : 2014.08.20
  • Accepted : 2015.01.22
  • Published : 2015.02.28
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Abstract

This study aims to design a monolayer cell adsorption apparatus that would help to produce high-quality slides for Liquid-Based Cytology (LBC) of an early cancer diagnosis for human bodies. The LBC collects exfoliated cells of human bodies and spreads the cells on the slides. Through processes of dyeing and cytological examination, the LBC screens for cancers in early stage. In this study, both of a cell suction module and a cell adsorption module, which are the key elements of the monolayer cell adsorption apparatus, were developed, and using those modules, the study set, first, conditions to help both GYN and NON-GYN apply principal cells without de-endothelialization before conducting its own analysis on the utility. As a results, for GYN, apparatus was determined to be able to produce high-quality slides under the condition of 4 and for NON-GYN, the apparatus would come up with other slides of high-quality under the condition of 2. The study carried out a repetitive test on selected conditions and proved 96% of the repetitive success rate. By the results of what has been learned so far, the study presents that the apparatus has a possibility to replace device from South Korea as one of those other currently-applied systems to run the LBC and that the system will also present a new paradigm for cancer diagnosis as it makes a contribution to the improvement in the LBC.

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