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폐쇄성 수면무호흡증 환자의 상하악 전진술 후 상기도 내 유동해석

Flow Analyses of Upper Airway Before and After Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea Patient

  • 김형호 (숭실대학교 기계공학과) ;
  • 서상호 (숭실대학교 기계공학과) ;
  • 최진영 (서울대학교 치의학대학원 구강악안면외과) ;
  • 김태윤 (서울대학교 치의학대학원 구강악안면외과)
  • Kim, Hyoung-Ho (Dept. of Mechanical Engineering, Soongsil Univ.) ;
  • Suh, Sang-Ho (Dept. of Mechanical Engineering, Soongsil Univ.) ;
  • Choi, Jin-Young (Dept. of Oral and Maxillofacial Surgey, School of Dentistry, Seoul Nat'l Univ.) ;
  • Kim, Taeyun (Dept. of Oral and Maxillofacial Surgey, School of Dentistry, Seoul Nat'l Univ.)
  • 투고 : 2015.01.30
  • 심사 : 2015.03.03
  • 발행 : 2015.05.01

초록

폐쇄성 수면무호흡증은 수면중 간헐적으로 반복되는 상기도 폐쇄 증상을 말한다. 상하악전진술은 폐쇄성 수면무호흡 치료에 가장 효과적인 외과적 수술 중 하나이다. 상하악 전진술을 통해 상기도의 부피가 증가되어 상기도의 막힘을 치료할 수 있다. 본 연구의 목적은 상하악전진술 전후의 상기도 내 유동해석을 수행하여 폐쇄성 수면무호흡증 환자의 흡기 및 호기 시의 유동현상을 분석하는 것이다. 생체내 CT 이미지로부터 상기도 모델링을 만들고, 상기도 내 상하악전진술 전 후 환자에 대한 단면적 변화 및 음압 효과에 대해 전산유체역학적 방법으로 연구하였다. 연구결과, 수술 후 SMA (section of minimum area)의 면적변화가 가장 컸으며 압력변화와 속도변화가 커진다는 것이 확인되었다. 수면무호흡증 환자에 대한 CFD 해석을 통한 연구는 치료효과에 대한 분석이 가능함을 임상적으로 확인하였다.

Obstructive sleep apnea (OSA) is a syndrome characterized by the repetitive episodic collapse of the upper airway. Maxillomandibular advancement surgery is one of the most effective surgical treatment methods in treating obstructive sleep apnea. The advancement of both maxill and mandible can enlarge the cross-sectional areas and volumes of the postero-superior airway. The purpose of this study is to analyze flow patterns in the upper airway before and after maxillomandibular advancement surgery. Here, we analyzed flow phenomena of inspiration and expiration to prevent obstructive sleep apnea patient from happening side effect. Modeling of the upper airway carried out from clinical CT scanned images. We used time-dependent values for boundary condition. CFD analyses were performed and evaluated section of minimum area (SMA), compared with patient inside upper airway before and after maxillomandibular advancement surgery in SMA, and negative pressure effects. The study showed the greatest enlargment of the section of minimum cross-sectional area. Moreover, the velocity and the negative airway pressure were decreased. According to the result of this study, the maxillomandibular advancement surgery stabilizes the airflow in the postero-superior airway of OSA patients.

키워드

참고문헌

  1. Holty, J. E. C. and Guilleminault, C., 2010, "Maxillomandibular Advancement for the Treatment of Obstructive Sleep Apnea: a Systematic Review and Meta-analysis," Sleep medicine reviews, Vol. 14, No. 5, pp. 287-297. https://doi.org/10.1016/j.smrv.2009.11.003
  2. Sittitavornwong, S., Waite, P. D., Shih, A. M., Cheng, G. C., Koomullil, R., Ito, Y. and Litaker, M., 2013, "Computational Fluid Dynamic Analysis of the Posterior Airway Space After Maxillomandibular Advancement for Obstructive Sleep Apnea Syndrome," Journal of Oral and Maxillofacial Surgery, Vol. 71, No. 8, pp. 1397-1405. https://doi.org/10.1016/j.joms.2013.02.022
  3. Tang, H., Tu, J. Y., Li, H. F., Au-Hijleh, B., Xue, C. C. and Li, C. G., 2004, December, "Dynamic Analysis of Airflow Features in a 3D Real-anatomical Geometry of the Human Nasal Cavity," In Proceedings of 15th Australasian Fluid Mechanics Conference, Australia, pp. 80-83.
  4. Garcia, G. J., Bailie, N., Martins, D. A. and Kimbell, J. S., 2007, "Atrophic Rhinitis: a CFD Study of Air Conditioning in the Nasal Cavity," Journal of Applied Physiology, Vol. 103, No. 3, pp. 1082-1092. https://doi.org/10.1152/japplphysiol.01118.2006
  5. Keyhani, K. P. W. M. M., Scherer, P. W. and Mozell, M. M., 1995, "Numerical Simulation of Airflow in the Human Nasal Cavity," Journal of Biomechanical Engineering, Vol. 117, No. 4, pp. 429-441. https://doi.org/10.1115/1.2794204
  6. Kelly, J. T., Prasad, A. K. and Wexler, A. S., 2000, "Detailed Flow Patterns in the Nasal Cavity," Journal of Applied Physiology, Vol. 89, No. 1, pp. 323-337. https://doi.org/10.1152/jappl.2000.89.1.323
  7. Chen, X. B., Lee, H. P., Chong, H., Fook, V. and Wang, D. Y., 2009, "Assessment of Septal Deviation Effects on Nasal Air Flow: a Computational Fluid Dynamics Model," The Laryngoscope, Vol. 119, No. 9, pp. 1730-1736. https://doi.org/10.1002/lary.20585
  8. Huynh, J., Kim, K. B. and McQuilling, M., 2009, "Pharyngeal Airflow Analysis in Obstructive Sleep Apnea Patients Pre-and Post-maxillomandibular Advancement Surgery," Journal of Fluids Engineering, Vol. 131, No. 9, 091101. https://doi.org/10.1115/1.3192137
  9. Mo, S. S., Ahn, H. T., Lee, J. S., Chung, Y. S., Moon, Y. S., Pae, E. K. and Sung, S. J., 2010, "Morphological Characteristics of the Upper Airway and Pressure Drop Analysis Using 3D CFD in OSA Patients," Korean Journal of Orthodontics, Vol. 40, No. 2, pp. 66-76. https://doi.org/10.4041/kjod.2010.40.2.66
  10. Hahn, I., Scherer, P. W. and Mozell, M. M., 1993, "Velocity profiles measured for airflow through a large-scale model of the human nasal cavity," Journal of Applied Physiology, 75, pp. 2273-2273. https://doi.org/10.1152/jappl.1993.75.5.2273
  11. Riazuddin, V. N., Zubair, M., Abdullah, M. Z., Ismail, R., Shuaib, I. L., Hamid, S. A. and Ahmad, K. A., 2011, "Numerical Study of Inspiratory and Expiratory Flow in a Human Nasal Cavity," Journal of Medical and Biological Engineering, Vol. 31, No. 3, pp. 201-206. https://doi.org/10.5405/jmbe.781
  12. Taylor, D. J., Doorly, D. J. and Schroter, R. C., 2010, "Inflow Boundary Profile Prescription for Numerical Simulation of Nasal Airflow," Journal of the Royal Society Interface, Vol. 7, No. 44, pp. 515-527. https://doi.org/10.1098/rsif.2009.0306
  13. Lindemann, J., Leiacker, R., Rettinger, G. and Keck, T., 2002, "Nasal mucosal temperature during respiration. Clinical Otolaryngology & Allied Sciences," Vol. 27, No. 3, pp. 135-139. https://doi.org/10.1046/j.1365-2273.2002.00544.x
  14. Wen, J., Inthavong, K., Tu, J. and Wang, S., 2008, "Numerical Simulations for Detailed Airflow Dynamics in a Human Nasal Cavity," Respiratory physiology & neurobiology, Vol. 161, No. 2, 125-135. https://doi.org/10.1016/j.resp.2008.01.012