디지털융복합연구 (Journal of Digital Convergence)

  • 제13권4호
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  • Pages.417-423
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  • 2015
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  • 2713-6434(pISSN)
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  • 2713-6442(eISSN)
한국디지털정책학회 (The Society of Digital Policy and Management)
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피부 미백제를 함유한 안정한 o/w 나노에멀젼의 융복합형 화장품 이용

Application of Stable o/w Nanoemulsions with Skin Depigmenting Agent for Integration Type of Cosmetics

  • Cho, Wan-Goo (Dept. of Basic Medical Science, Jeonju University)
  • 투고 : 2015.02.09
  • 심사 : 2015.04.20
  • 발행 : 2015.04.28
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⟨ 이전 논문 다음 논문 ⟩

초록

정제수/Span 80-Tween 80/화장품용 피부 미백제 계에서 PIC 방법을 이용하여 o/w 나노에멀젼을 제조하였다. 제조 온도를 30 oC에서 80 oC로 상승시킴에 따라 제조된 나노에멀젼의 입경은 150 nm에서 40 nm로 감소하여 나노에멀젼을 형성하였다. 혼합 계면활성제의 HLB를 변화함에 따라 13.0~14.0 부근에서 가장 작은 입경을 형성하는 최적 HLB가 존재하였다. 오일/유화제의 비율이 증가하면 에멀젼의 입자 크기가 증가하였다. $f{\leq}0.15$ 조건에서 나노에멀젼의 크기 분포는 2 개월 이상 일정하게 유지 되었다. 제조 온도의 증가는 단 분산 나노에멀젼의 제조를 가능하게 하였다. 나노에멀젼이 생성되면, Ostwald ripening에 대한 안정성은 연속 상에서 화장품용 피부 미백제의 매우 낮은 용해도로 인해 안정하였다.

Oil-in-water(o/w) nanoemulsions were prepared in the system of water/Span 80-Tween 80/long-chain paraffin oil via PIC method. With the increase of preparation temperature from 30 oC to 80 oC, the diameter of emulsion droplets decreased from 150 nm to 40 nm. By varying the HLB of mixed surfactants, we found that there was an optimum HLB around 13.0~14.0 corresponding to the minimum droplet size. The size of emulsion droplets increased upon increasing the ratio of oil/emulsifying agent. At $f{\leq}0.15$, the size of nanoemulsions could be kept constant more than 2 months. The increase in preparation temperature makes it possible for producing monodisperse nanoemulsions. Once the nanoemulsion is produced, the stability against Ostwald ripening is outstanding due to the extremely low solubility of the liquid paraffin oil in the continuous phase.

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