DOI QR코드

DOI QR Code

Development of Single-layer-structured Glucose Biosensor

  • Lee, Young-Tae (Department of Electronic Engineering Education, College of Education, Andong National University) ;
  • Kwon, Min Su (Center for Integrated Smart Sensors)
  • Received : 2015.01.07
  • Accepted : 2015.03.25
  • Published : 2015.03.31

Abstract

In this paper, we fabricated a low-cost glucose sensor with a simpler structure and fabrication process than the existing glucose sensor. The currently used glucose sensor has a three-layer structure with upper, middle, and bottom plates; here, we fabricated a single-layer glucose sensor using only a printing and dispensing process. We successfully fabricated the glucose sensor using a simple method involving the formation of an electrode and insulator layer through a 2- or 3-step printing process on plastic or paper film, followed by the dispensing of glucose oxidase solution on the electrode. Cyclic voltammetry (CV) and cyclic amperometry (CA) measurements were used to evaluate the characteristics of the fabricated single-layer glucose sensor. Also, its sensitivity was analyzed through glucose-controlled blood measurements. Hence, a low-cost single-layer glucose sensor was fabricated with evaluation of its characteristics demonstrating that it has useful application in medicine.

Keywords

References

  1. http://www.idf.org/.
  2. L. C. Clark, and C. Lyons, "Electorde system for continuous monitoring in cardiovacular", Annals New York Academy of Sciences, Vol. 102, pp. 29-45, 1962.
  3. Joseph Wang, "Electrochemical glucose biosensors", Chemical Reviews, Vol. 108, No. 2, pp. 814-825, 2008. https://doi.org/10.1021/cr068123a
  4. J. R. Mor, and R. Guarnaccia, "Assay of glucose using an electrochemical enzymatic sensor", Analytical Biochemistry, Vol. 79, pp. 319-328, 1977. https://doi.org/10.1016/0003-2697(77)90407-9
  5. J. Anzai, Y. Kobayashi, Y. Suzuki, H. Takeshita, Q. Chen, T. Osa, T. Hoshi, and X. Du, "Enzyme sensors prepared by layer-by-layer deposition of enzyme on the platinum electrode through avidin-biotin interaction", Sensors and Actuators B-Chem., Vol. 52, Issues 1-2, pp. 3-9, 1998. https://doi.org/10.1016/S0925-4005(98)00248-2
  6. N. G. Patel, S. Meier, K. Cammann, and G. C. Chemntius, "Screen-printed biosensors using defferent alcohol oxidase", Sensors and Actuators B-Chem., Vol. 75, Issues 1-2, pp. 101-110, 2001. https://doi.org/10.1016/S0925-4005(01)00545-7
  7. Y. T. Lee, and S. R. Lee, "Development of the disposable glucose sensor using Cu/Ni/Au electrode", Journal. of the Korea Sensors Society, Vol. 15, No. 5, pp.352-356, 2006.
  8. A. Y. Kim, and Y. T. Lee, "Development of eco-friendly paper glucose bio-sensor", Journal of Sensor Science and Technology, Vol. 22, No. 3, pp.202-206, 2013. https://doi.org/10.5369/JSST.2013.22.3.202