Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis

  • Kim, Hyejin (Haemaru Referral Animal Hospital) ;
  • Rather, Irfan A. (Department of Applied Microbiology and Biotechnology, Yeungnam University) ;
  • Kim, Hyunwook (Haemaru Referral Animal Hospital) ;
  • Kim, Sungsoo (Haemaru Referral Animal Hospital) ;
  • Kim, Taeeun (Haemaru Referral Animal Hospital) ;
  • Jang, Jaeyoung (Haemaru Referral Animal Hospital) ;
  • Seo, Jimin (Haemaru Referral Animal Hospital) ;
  • Lim, Jeongheui (National Science Museum Ministry of Science, ICT and Future Planning) ;
  • Park, Yong-Ha (Department of Applied Microbiology and Biotechnology, Yeungnam University)
  • Received : 2015.06.29
  • Accepted : 2015.08.11
  • Published : 2015.11.28
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Abstract

Canine atopic dermatitis (CAD) is a ubiquitous, chronic inflammatory skin disorder prevalent in dogs, which results in production of abnormal levels of IgE antibodies in reciprocation to an allergen challenge. In this study, administration of the probiotic strain Lactobacillus sakei probio-65 for 2 months significantly reduced the disease severity index in experimental dogs diagnosed with CAD. In addition, one month pre-medication of L. sakei probio-65 revealed significant difference in the PVAS score in experimental dogs for both probio-65 and placebo groups. However, post 2 months treatment resulted in a significant decrease in the CASESI score values in the probio-65-treated group (p < .0.06).

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References

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