한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제43권4호
  • /
  • Pages.373-377
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  • 2015
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  • 1598-642X(pISSN)
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  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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성숙 마가자의 혈액 응고저해 및 혈소판 응집저해 활성

Anti-coagulation and Anti-platelet Aggregation Activity of the Mature Fruit of Sorbus commixta

  • Kim, Mi-Sun (Department of Food and Nutrition, Andong National University) ;
  • Sohn, Ho-Yong (Department of Food and Nutrition, Andong National University)
  • 투고 : 2015.09.23
  • 심사 : 2015.11.05
  • 발행 : 2015.12.28
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초록

마가목의 열매인 마가자는 생식하거나 다류, 발효주로 제조되어 음용되며, 한방에서는 고혈압 및 관절염 치료 등에 사용되고 있다. 본 연구에서는 현재까지 보고되지 않은 마가자의 항혈전 활성을 평가하기 위해 울릉도 마가자의 ethanol 추출물 및 이의 순차적 유기용매 분획물을 조제하고 이의 혈액응고 저해 및 혈소판 응집저해 활성을 평가하였다. 그 결과, 마가자의 ethanol 추출물의 ethylacetate 분획에서 강력한 트롬빈, 프로트롬빈, 혈액응고인자 저해와 함께, 혈소판 응집저해 활성을, hexane 분획에서는 아스피린보다 강력한 혈소판 응집저해 활성을 확인하였다. 또한 마가자의 추출물 및 분획물들은 0.5 mg/ml 농도까지 인간 적혈구 용혈활성이 없음을 확인하여, 마가자의 활성분획물이 신규의 항혈전제로 사용 가능함을 제시하였다.

The mature fruit of Sorbus commixta is known as magaja in Korea and is consumed in the form of tea and wine. In addition, it has been used to treat hypertension and articular neuralgia in folk medicine. In this study, the ethanol extract of magaja and its subsequent organic solvent fractions were prepared, and their in vitro anti-coagulation, and platelet aggregation inhibitory activities were evaluated. Among the fractions, the ethylacetate fraction demonstrated significant inhibition against thrombin, prothrombin, blood coagulation factors and platelet aggregation, without hemolysis activity up to 0.5 mg/ml. Our results suggest that the ethylacetate fraction of magaja has the potential to be used as a new anti-coagulation agent.

키워드

참고문헌

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  5. The Sorbus spp.—Underutilised Plants for Foods and Nutraceuticals: Review on Polyphenolic Phytochemicals and Antioxidant Potential vol.9, pp.9, 2020, https://doi.org/10.3390/antiox9090813
  6. The Effects of Sorbus aucuparia L. Fruit Extracts on Oxidative/Nitrative Modifications of Human Fibrinogen, Impact on Enzymatic Properties of Thrombin, and Hyaluronidase Activity In Vitro vol.10, pp.12, 2015, https://doi.org/10.3390/antiox10122009