Biomaterials and Biomechanics in Bioengineering

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Recent advances in utilization of photochemical internalization (PCI) for efficient nano carrier mediated drug delivery

  • Park, Wooram (Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea) ;
  • Park, Sin-Jung (Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea) ;
  • Lee, Jun (Gyeonggi-Academy of Foreign Languages) ;
  • Na, Kun (Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea)
  • Received : 2015.01.23
  • Accepted : 2015.02.02
  • Published : 2015.03.25
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Abstract

Despite recent progresses in nanoparticle-based drug delivery systems, there are still many unsolved limitations. Most of all, a major obstacle in current nanoparticle-based drug carrier is the lack of sufficient drug delivery into target cells due to various biological barriers, such as: extracellular matrix, endolysosomal barrier, and drug-resistance associated proteins. To circumvent these limitations, several research groups have utilized photochemical internalization (PCI), an extension of photodynamic therapy (PDT), in design of innovative and efficient nano-carriers drug delivery. This review presents an overview of a recent research on utilization of PCI in various fields including: anti-cancer therapy, protein delivery, and tissue engineering.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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