The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Delayed Allergic Reaction to Secondary Administrated Epidural Hyaluronidase

  • Park, A Reum (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Kim, Woong Mo (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School) ;
  • Heo, Bong Ha (Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School)
  • Received : 2014.12.26
  • Accepted : 2015.01.02
  • Published : 2015.04.01
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Abstract

We are reporting a rare case of a delayed hypersensitivity reaction caused by hyaluronidase allergy following a lumbar transforaminal epidural block. Using an intradermal skin test, we have provided evidence that the systemic allergic reaction resulted from hypersensitivity to hyaluronidase. To our knowledge, this is a rare case of a delayed hypersensitivity reaction to epidural hyaluronidase, comprised of an initial exposure to hyaluronidase with no subsequent allergic response in prior block followed by a subsequent delayed reaction to hyaluronidase during a second epidural block.

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References

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