Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Pathologic Response During Chemo-radiotherapy and Variation of Serum VEGF Levels Could Predict Effects of Chemo-Radiotherapy in Patients with Esophageal Cancer

  • Yu, Jing-Ping (Department of Radiation Oncology, Changzhou NO.2 People's Hospital) ;
  • Lu, Wen-Bin (Department of Radiation Oncology, Changzhou NO.2 People's Hospital) ;
  • Wang, Jian-Lin (Department of Radiation Oncology, Changzhou NO.2 People's Hospital) ;
  • Ni, Xin-Chu (Department of Radiation Oncology, Changzhou NO.2 People's Hospital) ;
  • Wang, Jian (Department of Radiation Oncology, Changzhou NO.2 People's Hospital) ;
  • Sun, Zhi-Qiang (Department of Radiation Oncology, Changzhou NO.2 People's Hospital) ;
  • Sun, Su-Ping (Department of Radiation Oncology, Changzhou NO.2 People's Hospital)
  • Published : 2015.03.04
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Abstract

Background: To investigate the relationship between pathologic tumor response to concurrent chemoradiotherapy and variation of serum VEGF in patients with esophageal cancer. Materials and Methods: Forty six patients with esophageal cancer who were treated with concurrent chemo-radiotherapy were enrolled. Endoscopic and pathologic examination was conducted before and four weeks afterwards. Serum level of VEGF was documented before, four weeks later and after chemo-radiotherapy. The relationship between pathologic response and the variation of serum level of VEGF and its influence on the prognosis were investigated. Results: Serum level of VEGF decreased remarkably during and after chemo-radiotherapy in patients whose pathologic response was severe (F=5.393, 4.587, P(0.05). There were no statistical differences of serum VEGF level before, during and after chemo-radiotherapy for patients whose pathologic response was moderate or mild. There were 18 (85.7%), 7 (53.8%) and 6 patients (50.0%) whose serum VEGF level dropped in the severe, moderate and mild group, respectively, with significant differences among these groups (p=0.046). Two year survival rates of patients with severe, moderate and mild pathologic response were 61.9%, 53.8% and 33.3% respectively, and no statistically difference between severe and mild group regarding OS (p=0.245) was tested. Conclusions: Tumor pathologic response during chemo-radiotherapy and the changes of serum VEGF lever could predict curative effects of chemo-radiotherapy in patients with esophageal cancer.

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References

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