Korean Journal of Environmental Biology (환경생물)

Korean Society of Environmental Biology (한국환경생물학회)
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Safty of Alternatives for Endocirne Disrupting Substances

내분비계장애물질 대체소재의 안전성

  • Park, Chan Jin (Department of Life Science, College of Natural Sciences, Hangyang University) ;
  • Kim, Woong (Department of Life Science, College of Natural Sciences, Hangyang University) ;
  • Gye, Myung Chan (Department of Life Science, College of Natural Sciences, Hangyang University)
  • 박찬진 (한양대학교 자연과학대학 생명과학과) ;
  • 김웅 (한양대학교 자연과학대학 생명과학과) ;
  • 계명찬 (한양대학교 자연과학대학 생명과학과)
  • Received : 2015.12.04
  • Accepted : 2015.12.10
  • Published : 2015.12.31
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Abstract

Endocirne disruptors (EDs) can cause fertility decrease, developmental disorder, and even cancer in animals. Until 90's, EDs were used in various synthetic products including paints, coatings, detergents, plastics, and plasticizers. Currently, in several countries, the production, trade and use of EDs or EDs-suspected chemicals have been regulated while activity to screen the alternatives for EDs including bisphenol-A, phthalate and nonylphenol is active. Although various toxicity test method was developed and applied for screening of alternatives, however, the safety of alternatives has been not fully demonstrated. Some alternatives have high structural similarity with existing EDs, raising the possible risk of endocrine disruption by alternatives. In an effort to develop the safe alternatives, we reviewed the effects of EDs such as bisphenol-A, phthalates, nonylphenol and their substituents. In addition, in-silico analysis for endocrine disrupting activities of some alternatives was presented.

내분비계장애물질 (endocrine disruptors)은 포유류에서 축적되어 내분비계를 교란하며, 특히 수정능, 초기발생 등에 악영향을 미치고 암을 유발할 수 있는 것으로 잘 알려져 있다. 이러한 내분비계장애물질은 그 내분비계 교란 효과에 대한 지식이 부족하여 페인트, 코팅, 세제, 플라스틱 등에 활발히 사용되어 왔다. 특히 가정에서 내분비계장애물질은 음식 용기, 물병, 세탁용 세제 등에 사용되어 인체에 쉽게 노출되었다. 이후 내분비계장애물질의 위험성을 인식하면서 세계 각국에서는 내분비계장애물질의 생산 및 사용을 규제하고 대체재를 발굴하기 시작하였다. 그러나 현재까지 보고된 대체재의 안전성 또한 불확실하며, 이들의 인체에 대한 악영향을 완전히 파악하지 못한 채 사용하고 있다. 최근 이러한 대체재들 중 기존의 내분비계장애물질과 구조적으로 유사하고 내분비계 교란 효과를 갖는 물질이 있음이 밝혀졌으며, 이에 본 소고에서는 기존에 알려진 대표적인 내분비계장애물질인 bisphenol-A, phthalates, nonylphenols 및 이들의 대체재가 인체에 미치는 영향을 파악하고, 나아가 일부 대체재들에 대한 in-silico 분석을 수행함으로써 현존하는 대체재의 안전성에 의문을 제기하고 바람직한 소재 발굴을 위한 가이드를 제시하고자 하였다.

Keywords

References

  1. Alvarez-Chavez CR. 2009. Sustainability of Bio-Polymers: Comparative Analysis of Corn and Potato Based Bio-Polymers, Doctoral Dissertation, University of Massachusetts, USA.
  2. Api AM. 2001. Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients. Food Chem. Toxicol. 39:97-108. https://doi.org/10.1016/S0278-6915(00)00124-1
  3. Baba K, K Okada, T Kinoshita and S Imaoka. 2009. Bisphenol A disrupts Notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis. Toxicol. Sci. 108:344-355. https://doi.org/10.1093/toxsci/kfp025
  4. Bae S, JH Kim, YH Lim, HY Park and YC Hong. 2012. Associations of bisphenol A exposure with heart rate variability and blood pressure. Hypertension 60:786-793. https://doi.org/10.1161/HYPERTENSIONAHA.112.197715
  5. Bittner G and S Yaniger. 2012. Comment on "Lack of androgenicity and estrogenicity of the three monomers used in Eastman's $Tritan^{TM}$ copolyesters" by Osimitz et al. (2012). Food Chem. Toxicol. 50:4236-4237. https://doi.org/10.1016/j.fct.2012.06.038
  6. Bontje D, J Hermens, T Vermeire and T Damstra. 2005. Integrated risk assessment: nonylphenol case study. Report prepared for the WHO/UNEP/ILO International programme on chemical safety.
  7. Brooke D, J Burns, C Cartwright and A Pearson. 2009. Environmental risk evaluation report: Styrenated phenol. Environment Agency. Wallingford, UK.
  8. Cao XL and S Popovic. 2015. Bisphenol A and Three Other Bisphenol Analogues in Canned Fish Products from the Canadian Market 2014. J. Food Prot. 78:1402-1407. https://doi.org/10.4315/0362-028X.JFP-15-055
  9. Carson R. 1962. Silent spring, Boston, MA: Houghton Mifflin.
  10. Caserta D, L Maranghi, A Mantovani, R Marci, F Maranghi and M Moscarini. 2008. Impact of endocrine disruptor chemicals in gynaecology. Hum. Reprod. Update 14:59-72.
  11. Chen X, S Xu, T Tan, ST Lee, SH Cheng, FWF Lee, SJL Xu and KC Ho. 2014. Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures. Int. J. Environ. Res. Public Health 11:3156-3168. https://doi.org/10.3390/ijerph110303156
  12. Chiellini F, M Ferri, A Morelli, L Dipaola and G Latini. 2013. Perspectives on alternatives to phthalate plasticized poly (vinyl chloride) in medical devices applications. Prog. Polym. Sci. 38:1067-1088. https://doi.org/10.1016/j.progpolymsci.2013.03.001
  13. Colborn T, D Dumanoski and JP Myers. 1996. Our stolen future: are we threatening our fertility, intelligence, and survival?: a scientific detective story. Dutton Publishing, New York.
  14. DaSilva SC, RP Sahu, RL Konger, SM Perkins, MH Kaplan and JB Travers. 2012. Increased skin barrier disruption by sodium lauryl sulfate in mice expressing a constitutively active STAT6 in T cells. Arch. Dermatol. Res. 304:65-71. https://doi.org/10.1007/s00403-011-1168-2
  15. Eladak S, T Grisin, D Moison, MJ Guerquin, T N'Tumba-Byn, S Pozzi-Gaudin, A Benachi, G Livera, V Rouiller-Fabre and R Habert. 2015. A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil. Steril. 103:11-21. https://doi.org/10.1016/j.fertnstert.2014.11.005
  16. EPA. 1999. In the Environment, Active Agents. Endocrine Disruptor Screening and Testing Advisory Committee.
  17. Ghisari M and EC Bonefeld-Jorgensen. 2009. Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions. Toxicol. Lett. 189:67-77. https://doi.org/10.1016/j.toxlet.2009.05.004
  18. Gray LE, J Ostby, C Wolf, C Lambright and W Kelce. 1998. The value of mechanistic studies in laboratory animals for the prediction of reproductive effects in wildlife: Endocrine effects on mammalian sexual differentiation. Environ. Toxicol. Chem. 17:109-118. https://doi.org/10.1002/etc.5620170113
  19. Harris CA, P Henttu, MG Parker and JP Sumpter. 1997. The estrogenic activity of phthalate esters in vitro. Environ. Health Perspect. 105:802-811. https://doi.org/10.1289/ehp.97105802
  20. Hecker M and H Hollert. 2011. Endocrine disruptor screening: regulatory perspectives and needs. Environ. Sci. Eur. 23:1-14. https://doi.org/10.1186/2190-4715-23-1
  21. Henderson BE, RK Ross and MC Pike. 1993. Hormonal chemoprevention of cancer in women. Science 259:633-688. https://doi.org/10.1126/science.8381558
  22. Heudorf U, V Mersch-Sundermann and J Angerer. 2007. Phthalates: toxicology and exposure. Int. J. Hyg. Environ. Health 210:623-634. https://doi.org/10.1016/j.ijheh.2007.07.011
  23. IARC. 2015. Monographs on the Evaluation of Carcinogenic Risks to Humans: Complete List of Agents Evaluated and their Classification. International Agency for Research on Cancer. Lyon, France. Available at http://monographs.iarc.fr/ENG/Classification/index.php
  24. Ji K, S Hong, Y Kho and K Choi. 2013. Effects of bisphenol s exposure on endocrine functions and reproduction of zebrafish. Environ. Sci. Technol. 47:8793-8800. https://doi.org/10.1021/es400329t
  25. Jung B and K Lee. 2010. Current Status of Countermeasure for Overcoming the International Environmental Regulations in Korea. Clean Technol. 16:155-161.
  26. Kang IH, MG Kim, TS Kim, HS Nam, SG Hong and HJ Yoon. 2010. Current Status of OECD Endocrine Disruptor Testing and Assessment. Food Sci. Ind. 43:105-114.
  27. Kim HK, DW Jung, MY Lee and DH Ko. 2014. Method for preparing ester composition and resin composition. U.S. Patent Application 14/314,761.
  28. Kinch CD, K Ibhazehiebo, JH Jeong, HR Habibi and DM Kurrasch. 2015. Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proc. Natl. Acad. Sci. U. S. A. 112:1475-1480. https://doi.org/10.1073/pnas.1417731112
  29. Kluwe WM. 1982. Overview of phthalate ester pharmacokinetics in mammalian species. Environ. Health Perspect. 45:3-9. https://doi.org/10.1289/ehp.82453
  30. Layton L. 2010. Alternatives to BPA containers not easy for US foodmakers to find. Washington Post. 23 February.
  31. Lee DH. 2012. Endocrine disrupting chemicals and environmental diseases. J. Korean Med. Assoc. 55:243-249. https://doi.org/10.5124/jkma.2012.55.3.243
  32. LGchem. 2014. Non Phthalate plasticizer LGflex GL500. LG Polymer Journal.
  33. Lukaszczyk J, B Janicki and M Kaczmarek. 2011. Synthesis and properties of isosorbide based epoxy resin. Eur. Polym. J. 47:1601-1606. https://doi.org/10.1016/j.eurpolymj.2011.05.009
  34. Messina CM, C Faggio, VA Laudicella, M Sanfilippo, F Trischitta and A Santulli. 2014. Effect of sodium dodecyl sulfate (SDS) on stress response in the Mediterranean mussel (Mytilus Galloprovincialis): Regulatory volume decrease (Rvd) and modulation of biochemical markers related to oxidative stress. Aquat. Toxicol. 157:94-100. https://doi.org/10.1016/j.aquatox.2014.10.001
  35. Moynihan JT. 1996. Soybean oil-based intaglio ink and method for making same. U.S Patent NO. 5,569,701.
  36. Nah WH, MJ Park and MC Gye. 2011. Effects of early prepubertal exposure to bisphenol A on the onset of puberty, ovarian weights, and estrous cycle in female mice. Clin. Exp. Eeprod. Med. 38:75-81. https://doi.org/10.5653/cerm.2011.38.2.75
  37. Nara K, K Nishiyama, H Natsugari, A Takeshita and H Takahashi. 2009. Leaching of the plasticizer, acetyl tributyl citrate: (ATBC) from plastic kitchen wrap. J. Health Sci. 55:281-284. https://doi.org/10.1248/jhs.55.281
  38. Ng HW, M Shu, H Luo, H Ye, W Ge, R Perkins, W Tong and H Hong. 2015. Estrogenic Activity Data Extraction and in Silico Prediction Show the Endocrine Disruption Potential of Bisphenol A Replacement Compounds. Chem. Res. Toxicol. 28:1784-1795. https://doi.org/10.1021/acs.chemrestox.5b00243
  39. Ogawa Y, Y Kawamura, C Wakui, M Mutsuga, T Nishimura and K Tanamoto. 2006. Estrogenic activities of chemicals related to food contact plastics and rubbers tested by the yeast two-hybrid assay. Food Addit. Contam. 23:422-430. https://doi.org/10.1080/02652030500482371
  40. Osimitz TG, ML Eldridge, E Sloter, W Welsh, N Ai, GS Sayler, F Menn and C Toole. 2012. Lack of androgenicity and estrogenicity of the three monomers used in Eastman's TritanTM copolyesters. Food Chem. Toxicol. 50:2196-2205. https://doi.org/10.1016/j.fct.2012.02.010
  41. Park CJ, HS Kang and MC Gye. 2010. Effects of nonylphenol on early embryonic development, pigmentation and 3, 5, 3'-triiodothyronine-induced metamorphosis in Bombina orientalis (Amphibia: Anura). Chemosphere 81:1292-1300. https://doi.org/10.1016/j.chemosphere.2010.08.039
  42. Park MJ, IS Lee, EK Shin, H Joung and SI Cho. 2006. The timing of sexual maturation and secular trends of menarchial age in Korean adolescents. Korean J. Pediatr. 49:610-616. https://doi.org/10.3345/kjp.2006.49.6.610
  43. Park S, JM Lee, JW Kim, J Cheong, H Yun, YC Hong, Y Kim, D Han, H Yoo and MS Shin. 2015. Association between phthalates and externalizing behaviors and cortical thickness in children with attention deficit hyperactivity disorder. Psychol. Med. 45:1601-1612. https://doi.org/10.1017/S0033291714002694
  44. Parveen M, A Inoue, R Ise, M Tanji and R Kiyama. 2008. Evaluation of estrogenic activity of phthalate esters by gene expression profiling using a focused microarray (EstrArray). Environ. Toxicol. Chem. 27:1416-1425. https://doi.org/10.1897/07-399.1
  45. Poon R, P Lecavalier, R Mueller, V Valli, B Procter and I Chu. 1997. Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl) phthalate in the rat. Food Chem. Toxicol. 35:225-239. https://doi.org/10.1016/S0278-6915(96)00064-6
  46. Rocha BA, LF Azevedo, M Gallimberti, AD Campiglia and F Barbosa Jr. 2015. High Levels of Bisphenol A and Bisphenol S in Brazilian Thermal Paper Receipts and Estimation of Daily Exposure. J. Toxicol. Environ. Health A. 78:1181-1188. https://doi.org/10.1080/15287394.2015.1083519
  47. Rochester JR. 2013. Bisphenol A and human health: a review of the literature. Reprod. Toxicol. 42:132-155. https://doi.org/10.1016/j.reprotox.2013.08.008
  48. Rochester JR and AL Bolden. 2015. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes. Environ. Health Perspect. 123:643-650.
  49. Rochman CM, MA Browne, BS Halpern, BT Hentschel, E Hoh, HK Karapanagioti, LM Rios-Mendoza, H Takada, S Teh and RC Thompson. 2013. Policy: Classify plastic waste as hazardous. Nature 494:169-171. https://doi.org/10.1038/494169a
  50. Rose M and R Palkovits. 2012. Isosorbide as a Renewable Platform chemical for Versatile Applications-Quo Vadis?. ChemSusChem. 5:167-176. https://doi.org/10.1002/cssc.201100580
  51. Roy JR, S Chakraborty and TR Chakraborty. 2009. Estrogen-like endocrine disrupting chemicals affecting puberty in humans-a review. Med. Sci. Rev. 15:RA137-RA145.
  52. Ruan T, D Liang, S Song, M Song, H Wang and G Jiang. 2015. Evaluation of the in vitro estrogenicity of emerging bisphenol analogs and their respective estrogenic contributions in municipal sewage sludge in China. Chemosphere 124:150-155. https://doi.org/10.1016/j.chemosphere.2014.12.017
  53. Satoh K, K Ohyama, N Aoki, M Iida and F Nagai. 2004. Study on anti-androgenic effects of bisphenol a diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their derivatives using cells stably transfected with human androgen receptor, AR-EcoScreen. Food Chem. Toxicol. 42:983-993. https://doi.org/10.1016/j.fct.2004.02.011
  54. Shehata AS, ZAER Mohamed, MRA El-Haleem and MA Samak. 2013. Effects of Exposure to Plasticizers Di- (2-Ethylhexyl) Phthalate and Trioctyltrimellitate on the Histological Structure of Adult Male Albino Rats' Liver. J. Clin. Toxicol. 3:169.
  55. Simmchen J, R Ventura and J Segura. 2012. Progress in the removal of di-[2-ethylhexyl]-phthalate as plasticizer in blood bags. Transf. Med. Rev. 26:27-37. https://doi.org/10.1016/j.tmrv.2011.06.001
  56. Singh AR, WH Lawrence and J Autian. 1972. Teratogenicity of phthalate esters in rats. J. Pharm. Sci. 61:51-55. https://doi.org/10.1002/jps.2600610107
  57. Singh S and SSL Li. 2011. Phthalates: Toxicogenomics and inferred human diseases. Genomics 97:148-157. https://doi.org/10.1016/j.ygeno.2010.11.008
  58. Song MH, YD Cho, EK Choe and YC Myoung. 2012. Study on verification of various national standards regarding phthalate testing in industrial products. Anal. Sci. Technol. 25:178-189. https://doi.org/10.5806/AST.2012.25.3.178
  59. Soto AM and C Sonnenschein. 2010. Environmental causes of cancer: endocrine disruptors as carcinogens. Nat. Rev. Endocrinol. 6:363-370. https://doi.org/10.1038/nrendo.2010.87
  60. Staples CA, PB Dome, GM Klecka, ST Oblock and LR Harris. 1998. A review of the environmental fate, effects, and exposures of bisphenol A. Chemosphere 36:2149-2173. https://doi.org/10.1016/S0045-6535(97)10133-3
  61. Swan SH, KM Main, F Liu, SL Stewart, RL Kruse, AM Calafat, CS Mao, JB Redmon, CL Ternand and S Sullivan. 2005. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ. Health Perspect. 113:1056-1061. https://doi.org/10.1289/ehp.8100
  62. ter Veld MG, B Schouten, J Louisse, DS van Es, PT van der Saag, IM Rietjens and AJ Murk. 2006. Estrogenic potency of food-packaging-associated plasticizers and antioxidants as detected in ERalpha and ERbeta reporter gene cell lines. J. Agric. Food Chem. 54:4407-4416. https://doi.org/10.1021/jf052864f
  63. Vandenberg LN, R Hauser, M Marcus, N Olea and WV Welshons. 2007. Human exposure to bisphenol A (BPA). Reprod. Toxicol. 24:139-177. https://doi.org/10.1016/j.reprotox.2007.07.010
  64. Williams F. 2012. Breasts: a natural and unnatural history. WW Norton & Company, New York.
  65. Yang CZ, SI Yaniger, V Jordan, DJ Klein and GD Bittner. 2011. Most plastic products release estrogenic chemicals: a potential health problem that can be solved. Environ. Health Perspect. 119:989-996. https://doi.org/10.1289/ehp.1003220
  66. Yeo MK. 2002. A Study on the Effects and Control Policy of Endocrine Disruptor. pp. 177. Korea Institute of Criminology. Seoul.
  67. Zhou J and H Ritter. 2011. Copolyesters as non-toxic plasticizers. Polym. Int. 60:1158-1161. https://doi.org/10.1002/pi.3122
  68. Zhao X and JM Courtney. 2009. Update on medical plasticized PVC. pp. 122. 1st ed. Shrewsbury, UK: Smithers Rapra.