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Multiple myeloma presenting with a maxillary lesion as the first sign

  • Ramaiah, Kiran Kumar Kotagudda (Department of Oral Medicine and Radiology, Navodaya Dental College and Hospital) ;
  • Joshi, Vajendra (Department of Oral Medicine and Radiology, Navodaya Dental College and Hospital) ;
  • Thayi, Shilpa Ravishankar (Department of Oral Medicine and Radiology, Navodaya Dental College and Hospital) ;
  • Sathyanarayana, Pathalapate (Department of Oral Medicine and Radiology, Navodaya Dental College and Hospital) ;
  • Patil, Prashant (Department of Oral Medicine and Radiology, Navodaya Dental College and Hospital) ;
  • Ahmed, Zaheer (Department of Public Health Dentistry, Navodaya Dental College and Hospital)
  • 투고 : 2014.07.29
  • 심사 : 2014.10.27
  • 발행 : 2015.03.31

초록

Multiple myeloma is a clonal neoplastic proliferation of terminally differentiated B-lymphocytes involving the skeletal system in a multifocal fashion. Its oral manifestations are less common in the maxilla than in the mandible due to the lower amount of hemopoietic bone marrow in the maxilla. We report the case of a 50-year-old man who presented with a mass in the left maxillary alveolar region with tooth mobility. The mass had become enlarged after the teeth were extracted 15 days previously. Radiographs demonstrated multiple punched-out radiolucent lesions in the skull and pelvic region. Computed tomography images showed a soft tissue density mass in the left maxilla, eroding the floor and walls of the maxillary sinus. Although several analytical techniques were used to characterize the lesion, it was finally confirmed as multiple myeloma through immunohistochemistry.

키워드

참고문헌

  1. Sharma V, Sharma A. Punched-out lesions in skull. Multiple myeloma. N Z Med J 2010; 123: 81-2.
  2. Lee SH, Huang JJ, Pan WL, Chan CP. Gingival mass as the primary manifestation of multiple myeloma: report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 82: 75-9. https://doi.org/10.1016/S1079-2104(96)80380-5
  3. Bruce KW, Royer RQ. Multiple myeloma occurring in the jaws: a study of 17 cases. Oral Surg Oral Med Oral Pathol 1953; 6: 729-44. https://doi.org/10.1016/0030-4220(53)90199-6
  4. Witt C, Borges AC, Klein K, Neumann HJ. Radiographic manifestations of multiple myeloma in the mandible: a retrospective study of 77 patients. J Oral Maxillofac Surg 1997; 55: 450-5. https://doi.org/10.1016/S0278-2391(97)90687-X
  5. Raubenheimer EJ, Lello GE, Dauth J, Fayman MS, Dvornak N, Senekal JC. Multiple myeloma presenting as localized expansile jaw tumour. Int J Oral Maxillofac Surg 1988; 17: 382-5. https://doi.org/10.1016/S0901-5027(88)80068-7
  6. Raley LL, Granite EL. Plasmacytoma of the maxilla: report of case. J Oral Surg 1977; 35: 497-500.
  7. Currie WJ, Hill RR, Keshani DK. An unusual case of maxillary tuberosity enlargement. Br Dent J 1994; 177: 60-2. https://doi.org/10.1038/sj.bdj.4808508
  8. Albright RL, Finkelman A, Doner JM, Beaubien R. Multiple myeloma with manifestation of a maxillary bony lesion and plasmacytoma. Oral Surg Oral Med Oral Pathol 1968; 26: 167-72. https://doi.org/10.1016/0030-4220(68)90245-4
  9. Lesmes D, Laster Z. Plasmacytoma in the temporomandibular joint: a case report. Br J Oral Maxillofac Surg 2008; 46: 322-4. https://doi.org/10.1016/j.bjoms.2007.06.009
  10. Bird JM, Owen RG, D'Sa S, Snowden JA, Pratt G, Ashcroft J, et al. Guidelines for the diagnosis and management of multiple myeloma 2011. Br J Haematol 2011; 154: 32-75. https://doi.org/10.1111/j.1365-2141.2011.08573.x
  11. Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003; 78: 21-33. https://doi.org/10.4065/78.1.21
  12. Lambertenghi-Deliliers G, Bruno E, Cortelezzi A, Fumagalli L, Morosini A. Incidence of jaw lesions in 193 patients with multiple myeloma. Oral Surg Oral Med Oral Pathol 1988; 65: 533-7. https://doi.org/10.1016/0030-4220(88)90135-1
  13. Nau KC, Lewis WD. Multiple myeloma: diagnosis and treatment. Am Fam Physician 2008; 78: 853-9.
  14. Ashcroft AJ, Davies FE, Morgan GJ. Aetiology of bone disease and the role of bisphosphonates in multiple myeloma. Lancet Oncol 2003; 4: 284-92. https://doi.org/10.1016/S1470-2045(03)01076-3
  15. Mozaffari E, Mupparapu M, Otis L. Undiagnosed multiple myeloma causing extensive dental bleeding: report of a case and review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 448-53. https://doi.org/10.1067/moe.2002.125201
  16. Witt C, Borges AC, Klein K, Neumann HJ. Radiographic manifestations of multiple myeloma in the mandible: a retrospective study of 77 patients. J Oral Maxillofac Surg 1997; 55: 450-3. https://doi.org/10.1016/S0278-2391(97)90687-X
  17. Miller CD, Goltry RR, Shenasky JH. Multiple myeloma involving the mandible. Report of a case. Oral Surg Oral Med Oral Pathol 1969; 28: 603-9. https://doi.org/10.1016/0030-4220(69)90270-9
  18. Pisano JJ, Coupland R, Chen S, Miller AS. Plasmacytoma of the oral cavity and jaws: a clinicopathologic study of 13 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 83:265-71. https://doi.org/10.1016/S1079-2104(97)90015-9
  19. Lae ME, Vencio EF, Inwards CY, Unni KK, Nascimento AG. Myeloma of the jaw bones: a clinicopathologic study of 33 cases. Head Neck 2003; 25: 373-81. https://doi.org/10.1002/hed.10210
  20. Durie BG, Waxman AD, D'Agnolo A, Williams CM. Whole body (18)F-FDG PET identifies high-risk myeloma. J Nucl Med 2002; 43: 1457-63.
  21. Schirrmeister H, Buck AK, Bergmann L, Reske SN, Bommer M. Positron emission tomography (PET) for staging of solitary plasmacytoma. Cancer Biother Radiopharm 2003; 18: 841-5. https://doi.org/10.1089/108497803770418382
  22. Wood NK, Goaz PW. Differential diagnosis of oral and maxillofacial lesions. 5th ed. St. Louis: Mosby; 1997. p. 387-9.
  23. Zhao XJ, Sun J, Wang YD, Wang L. Maxillary pain is the first indication of the presence of multiple myeloma: a case report. Mol Clin Oncol 2014; 2: 59-64. https://doi.org/10.3892/mco.2013.200

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