YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis of 8-Cycloalkoxychrysin Analogs and their Inhibitory Activity Against NO Production

고리형 알콕시기를 함유한 크리신 유도체의 합성 및 일산화질소 생성 억제작용

  • Kim, Sung-Soo (School of Medicine, Kangwon National University) ;
  • Park, Haeil (College of Pharmacy, Kangwon National University)
  • Received : 2015.01.23
  • Accepted : 2015.02.13
  • Published : 2015.02.28
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Abstract

Several 8-cycloalkoxychrysin analogs were synthesized from 6-benzyloxy-5,8-dihydroxyflavone and cycloalkanols in 2 steps and we evaluated their inhibitory activities against NO production from LPS-induced RAW 264.7 cells. Among tested analogs, two analogs with cyclopentyl substructure (796 and 798) showed strong inhibitory activity against NO production.

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References

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