Journal of Dairy Science and Biotechnology

Korean Society of Dairy Science and Biotechnology (한국낙농식품응용생물학회)
권호 표지

Preventive Effect of Milk Products against Diabetes Mellitus Type 2: A Review

유제품의 제2형 당뇨병 예방 효과: 총설

  • Kim, Dong-Hyeon (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Chon, Jung-Whan (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Kim, Hyun-Sook (Dept. of Veterinary Physiology, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Hong-Seok (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Song, Kwang-Young (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Kim, Young-Ji (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Kang, Il-Byung (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Lee, Soo-Kyung (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University) ;
  • Jeong, Dong-Gwan (Dept. of Food & Nutrition, College of Natural Science, Kosin University) ;
  • Kim, Soo-Ki (Dept. of Animal Science & Technology, College of Animal Bioscience & Technology, Konkuk University) ;
  • Seo, Kun-Ho (KU Center for Food Safety and College of Veterinary Medicine, Konkuk University)
  • 김동현 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 천정환 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 김현숙 (건국대학교 수의과대학 수의생리학전공) ;
  • 김홍석 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 송광영 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 김영지 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 강일병 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 이수경 (건국대학교 수의과대학 및 KU 식품안전연구소) ;
  • 정동관 (고신대학교 자연과학대학 식품영양학과) ;
  • 김수기 (건국대학교 동물생명과학대학 동물자원학과) ;
  • 서건호 (건국대학교 수의과대학 및 KU 식품안전연구소)
  • Received : 2015.05.30
  • Accepted : 2015.06.18
  • Published : 2015.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Diabetes mellitus type 2 is a metabolic disorder that is characterized by hyperglycemia (high blood sugar level) in the context of insulin resistance and relative lack of insulin. Recently, much scientific evidence has shown that the risk of diabetes mellitus type 2 could be reduced by dairy intake. A significantly strong relationship has been noted between this disease and dairy intake. In particular, from the different types of fat in dairy foods that were reported to have a beneficial impact, low-fat dairy foods have been found to have the best effect with respect to reducing the risk of diabetes mellitus type 2. Therefore, the role of specific components of dairy foods, such as calcium, vitamin D, dairy fat, and trans-palmitoleic acid, which could be responsible for this effect and for the positive effect of dairy foods in obesity and metabolic syndrome, needs to be identified. There is a strong and relatively consistent body of accumulating evidence indicating that dairy foods may significantly reduce the risk of diabetes mellitus type 2, likely in a dose-response manner. Dairy recommendations should be an essential part of public health guidance, and identifying strategies to increase dairy food consumption to optimal levels is of utmost importance. Hence, this review summarizes various positive effects of dairy foods with respect to reducing the risk of diabetes mellitus type 2, based on available evidence, and discusses the need for further research on preventing or decreasing the risk of diabetes mellitus type 2.

최근에 유제품의 섭취가 제2형 당뇨병의 위험성을 낮춘다는 연구결과가 점점 증가하고 있는 추세이다. 지금까지 발표된 유제품 섭취와 제2형 당뇨병 위험성의 관계에 대한 증거들을 검토해 보면, 유제품의 섭취와 제2형 당뇨병의 위험성 사이, 그리고 유제품의 섭취량에 따라 제2형 당뇨병의 발병률에 다양한 영향을 미치는 것으로 밝혀졌다. 특히 저지방 유제품의 섭취와 제2형 당뇨병의 위험성 감소는 일정한 관계를 보였으며, 일반적인 지방을 함유한 유제품은 인체에 좋은 영향을 주는 것으로 밝혀졌다. 하지만 몇몇 특정 유제품이 인체에 미치는 역할을 명확하게 확인할 향후 연구가 요구된다. 유제품이 제2형 당뇨병의 위험성을 낮추는 기전은 아직까지 명확하지 않지만, 유제품이 비만과 신진대사장애에 작용하는 기전과 유사할 것으로 사료되고 있다. 시간이 지날수록 유제품의 섭취가 제2형 당뇨병의 위험성을 낮춘다는 연구 결과와 일관성 있는 결과들이 지속적으로 제공되고 있다. 일반적인 지방과 특정 유제품을 더 잘 이해하기 위해서는 더 많은 연구가 진행되어야 하며, 지금까지의 연구 결과를 뒷받침하기 위해서는 잘 설계된 무작위통제실험과 기계적 연구를 통해 임상실험으로 반드시 검증하여야 하며, 이러한 노력들이 임상실습 및 공중보건지침으로 이행될 수 있도록 많은 노력이 절실히 요구 되어지고 있다.

Keywords

References

  1. Abargouei, A. S., Janghorbani, M., Salehi-Marzijarani, M. and Esmaillzadeh, A. 2012. Effect of dairy consumption on weight and body composition in adults: a systematic review and meta-analysis of randomized controlled clinical trials. Int. J. Obes. (Lond) 36:1485-1493. https://doi.org/10.1038/ijo.2011.269
  2. Alhazmi, A., Stojanovski, E., McEvoy, M. and Garg, M. L. 2012. Macronutrient intakes and development of type 2 diabetes: a systematic review and meta-analysis of cohort studies. J. Am. Coll. Nutr. 31:243-258. https://doi.org/10.1080/07315724.2012.10720425
  3. Bland, R., Markovic, D., Hills, C. E., Hughes, S. V., Chan, S. L. and Squires, P. E. 2004. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J. Steroid Biochem. Mol. Biol. 89-90:121-125. https://doi.org/10.1016/j.jsbmb.2004.03.115
  4. Chen, M., Pan, A., Malik, V. S. and Hu, F. B. 2012. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 96:735-747. https://doi.org/10.3945/ajcn.112.037119
  5. Christensen, R., Lorenzen, J. K., Svith, C. R., Bartels, E. M., Melanson, E. L. and Saris, W. H. 2009. Effect of calcium from dairy and dietary supplements on faecal fat excretion: a meta-analysis of randomized controlled trials. Obes. Rev. 10:475-486. https://doi.org/10.1111/j.1467-789X.2009.00599.x
  6. Crichton, G. E., Bryan, J., Buckley, J. and Murphy, K. J. 2012. Dairy consumption and metabolic syndrome: a systematic review of findings and methodological issues. Obes. Rev. 12:e190-201.
  7. Dimopoulos, N., Watson, M., Sakamoto, K. and Hundal, H. S. 2006. Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochem. J. 399:473-481. https://doi.org/10.1042/BJ20060244
  8. Doidge, J. C. and Segal, L. 2012. Most Australians do not meet recommendations for dairy consumption: findings of a new technique to analyse nutrition surveys. Aust. N. Z. J. Public Health 36:236-240. https://doi.org/10.1111/j.1753-6405.2012.00870.x
  9. Duncan, B. B., Schmidt, M. I., Pankow, J. S., Ballantyne, C. M., Couper, D. and Vigo, A. 2003. Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 52:1799-1805. https://doi.org/10.2337/diabetes.52.7.1799
  10. Dunlop, T. W., Vaisanen, S., Frank, C., Molnar, F., Sinkkonen, L. and Carlberg, C. 2005. The human peroxisome proliferatoractivated receptor delta gene is a primary target of 1alpha, 25-dihydroxyvitamin D3 and its nuclear receptor. J. Mol. Biol. 349:248-260. https://doi.org/10.1016/j.jmb.2005.03.060
  11. Elwood, P. C., Givens, D. I., Beswick, A. D., Fehily, A. M., Pickering, J. E. and Gallacher, J. 2008. The survival advantage of milk and dairy consumption: an overview of evidence from cohort studies of vascular diseases, diabetes and cancer. J. Am. Coll. Nutr. 27:723S-734S. https://doi.org/10.1080/07315724.2008.10719750
  12. Fumeron, F., Lamri, A., Abi Khalil, C., Jaziri, R., Porchay-Balderelli, I. and Lantieri, O. 2011. Dairy consumption and the incidence of hyperglycemia and the metabolic syndrome: results from a French prospective study, Data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care 34:813-817. https://doi.org/10.2337/dc10-1772
  13. Garriguet, D. 2007. Canadians' eating habits. Health Rep. 18:17-32.
  14. Gonzalez, J. T., Rumbold, P. L. and Stevenson, E. J. 2012. Effect of calcium intake on fat oxidation in adults: a metaanalysis of randomized, controlled trials. Obes. Rev. 13:848-857. https://doi.org/10.1111/j.1467-789X.2012.01013.x
  15. Grantham, N. M., Magliano, D. J., Hodge, A., Jowett, J., Meikle, P. and Shaw, J. E. 2013. The association between dairy food intake and the incidence of diabetes in Australia: the Australian Diabetes Obesity and Lifestyle Study (AusDiab). Public Health Nutr. 16:339-345. https://doi.org/10.1017/S1368980012001310
  16. International Diabetes Federation (IDF). 2013. The IDF Annual Report 2013 (available at: http://www.idf.org/sites/default/files/attachments/IDF-AR2013-final-rv.pdf).
  17. Kalergis, M., Leung Yinko, S. S. L. and Nedelcu, R. 2013. Dairy products and prevention of type 2 diabetes: implications for research and practice. Front. Endocrinol. 4:90.
  18. Kratz, M., Baars, T. and Guyenet, S. 2013. The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease. Eur. J. Nutr. 52:1-24.
  19. Krebs-Smith, S. M., Guenther, P. M., Subar, A. F., Kirkpatrick, S. I. and Dodd, K. W. 2010. Americans do not meet federal dietary recommendations. J. Nutr. 140:1832-1838. https://doi.org/10.3945/jn.110.124826
  20. Lee, J. I., Song, K. Y., Chon, J. W., Hyeon, J. Y. and Seo, K. H. 2011. The Effects of Kefir on MA-104 cells infected with human rotavirus and diabetic mouse: Review. Korean J. Dairy Sci. Technol. 29:1-15.
  21. Liu, A. D., Zhang, B., Du, W. W., Wang, H. J., Su, C. and Zhai, F. Y. 2011. Milk consumption and its changing trend of Chinese adult aged 18-44 in nine provinces (autonomous region) from 1991 to 2006. Zhonghua Yu Fang Yi Xue Za Zhi 45:304-309.
  22. Louie, J. C., Flood, V. M., Hector, D. J., Rangan, A. M. and Gill, T. P. 2011. Dairy consumption and overweight and obesity: a systematic review of prospective cohort studies. Obes. Rev. 12:e582-592. https://doi.org/10.1111/j.1467-789X.2011.00881.x
  23. Louie, J. C., Flood, V. M., Rangan, A. M., Burlutsky, G., Gill, T. P. and Gopinath, B. 2013. Higher regular fat dairy consumption is associated with lower incidence of metabolic syndrome but not type 2 diabetes. Nutr. Metab. Cardiovasc. Dis. 23:816-821 https://doi.org/10.1016/j.numecd.2012.08.004
  24. Luquet, S., Gaudel, C., Holst, D., Lopez-Soriano, J., Jehl-Pietri, C. and Fredenrich, A. 2005. Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes. Biochim. Biophys. Acta. 1740:313-317. https://doi.org/10.1016/j.bbadis.2004.11.011
  25. Maestro, B., Campion, J., Davila, N. and Calle, C. 2000. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr. J. 47:383-391. https://doi.org/10.1507/endocrj.47.383
  26. Malik, V. S., Sun, Q., Van Dam, R. M., Rimm, E. B., Willett, W. C. and Rosner, B. 2011. Adolescent dairy product consumption and risk of type 2 diabetes in middle-aged women. Am. J. Clin. Nutr. 94:854-861. https://doi.org/10.3945/ajcn.110.009621
  27. Mozaffarian, D., Cao, H., King, I. B., Lemaitre, R. N., Song, X. and Siscovick, D. S. 2010. Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study. Ann. Intern. Med. 153:790-799. https://doi.org/10.7326/0003-4819-153-12-201012210-00005
  28. Mozaffarian, D., De Oliveira Otto, M. C., Lemaitre, R. N., Fretts, A. M., Hotamisligil, G. and Tsai, M. Y. 2013. Trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA). Am. J. Clin. Nutr. 97:854-861. https://doi.org/10.3945/ajcn.112.045468
  29. Mozaffarian, D., Hao, T., Rimm, E. B., Willett, W. C. and Hu, F. B. 2011. Changes in diet and lifestyle and long-term weight gain in women and men. N. Engl. J. Med. 364:2392-2404. https://doi.org/10.1056/NEJMoa1014296
  30. Ojuka, E. O. 2004. Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle. Proc. Nutr. Soc. 63:275-278. https://doi.org/10.1079/PNS2004339
  31. Pal, S., Ellis, V. and Dhaliwal, S. 2010. Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals. Br. J. Nutr. 104:716-723. https://doi.org/10.1017/S0007114510000991
  32. Pihlanto-Leppala, A., Koskinen, P., Piilola, K., Tupasela, T. and Korhonen, H. 2000. Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. J. Dairy Res. 67:53-64. https://doi.org/10.1017/S0022029999003982
  33. Pittas, A. G., Joseph, N. A. and Greenberg, A. S. 2004. Adipocytokines and insulin resistance. J. Clin. Endocrinol. Metab. 89:447-452. https://doi.org/10.1210/jc.2003-031005
  34. Pittas, A. G., Lau, J., Hu, F. B. and DawsonHughes, B. 2007. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 92:2017-2029. https://doi.org/10.1210/jc.2007-0298
  35. Pradhan, A. D., Manson, J. E., Rifai, N., Buring, J. E. and Ridker, P. M. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334. https://doi.org/10.1001/jama.286.3.327
  36. Rideout, T. C., Marinangeli, C. P., Martin, H., Browne, R. W. and Rempel, C. B. 2013. Consumption of low-fat dairy foods for 6 months improves insulin resistance without adversely affecting lipids or bodyweight in healthy adults: a randomized free-living cross-over study. Nutr. J. 12:56. https://doi.org/10.1186/1475-2891-12-56
  37. Sluijs, I., Forouhi, N. G., Beulens, J. W., van der Schouw, Y. T., Agnoli, C. and Arriola, L. 2012. The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study. Am. J. Clin. Nutr. 96:382-390. https://doi.org/10.3945/ajcn.111.021907
  38. Soedamah-Muthu, S. S., Masset, G., Verberne, L., Geleijnse, J. M. and Brunner, E. J. 2012. Consumption of dairy products and associations with incident diabetes, CHD and mortality in the Whitehall II study. Br. J. Nutr. 109:718-726.
  39. Struijk, E. A., Heraclides, A., Witte, D. R., Soedamah-Muthu, S. S., Geleijnse, J. M. and Toft, U. and Lau C. J. 2013. Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes. Nutr. Metab. Cardiovasc. Dis. 23:822-828. https://doi.org/10.1016/j.numecd.2012.05.011
  40. Tong, X., Dong, J. Y., Wu, Z. W., Li, W. and Qin, L. Q. 2011. Dairy consumption and risk of type 2 diabetes mellitus: a meta-analysis of cohort studies. Eur. J. Clin. Nutr. 65: 1027-1031. https://doi.org/10.1038/ejcn.2011.62
  41. United States Department of Agriculture (USDA). 2010. Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans 2010 to the Secretary of Health and Human Services and the Secretary of Agriculture. Washington, DC.
  42. Vandevijvere, S., De Vriese, S., Huybrechts, I., Moreau, M., Temme, E. and De Henauw, S. 2009. The gap between food-based dietary guidelines and usual food consumption in Belgium, 2004. Public Health Nutr. 12:423-431.
  43. Wright, D. C., Hucker, K. A., Holloszy, J. O. and Han, D. H. 2004. $Ca^{2+}$ and AMPK both mediate stimulation of glucose transport by muscle contractions. Diabetes 53:330-335. https://doi.org/10.2337/diabetes.53.2.330
  44. Zemel, M. B. 1998. Nutritional and endocrine modulation of intracellular calcium: implications in obesity, insulin resistance and hypertension. Mol. Cell. Biochem. 188:129-136. https://doi.org/10.1023/A:1006880708475
  45. Zemel, M. B. 2005. The role of dairy foods in weight management. J. Am. Coll. Nutr. 24:537S-546S. https://doi.org/10.1080/07315724.2005.10719502
  46. Zemel, M. B., Shi, H., Greer, B., Dirienzo, D. and Zemel, P. C. 2000. Regulation of adiposity by dietary calcium. FASEB J. 14:1132-1138. https://doi.org/10.1096/fasebj.14.9.1132