Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Indolent Metastatic Squamous Cell Carcinoma of Unknown Primary in the Intrathoracic Lymph Node: A Case Report and Review of the Literatures

  • Kim, Min Jin (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Lim, Sang Hyok (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Han, Su Jung (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Choi, Kang Hyug (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Lee, Sun Hyo (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Park, Min Woo (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Kang, HyeRan (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Na, Ju Ock (Department of Internal Medicine, Soonchunhyang University College of Medicine)
  • Received : 2014.08.04
  • Accepted : 2014.09.22
  • Published : 2015.01.30
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Abstract

Metastatic squamous cell carcinoma from a cancer of unknown primary (CUP) affecting the intrathoracic lymph node is very rare. We reported a case of metastatic squamous cell carcinoma in the hilar and interlobar lymph node from a patient with CUP and reviewed the associated literature. Abnormal mass in the right hilar area was incidentally detected. A chest computed tomography scan showed a 2.5-cm diameter mass in the right hilum that had changed little in size for 3 years. The patient underwent a right pneumonectomy and mediastinal lymph node dissection. A metastatic squamous cell carcinoma in the hilar and interlobar lymph nodes without a primary lung or other lesion was diagnosed. The patient received adjuvant chemotherapy for a diagnosis of T0N1M0 lung cancer.

Keywords

References

  1. Muir C. Cancer of unknown primary site. Cancer 1995;75(1 Suppl):353-6. https://doi.org/10.1002/1097-0142(19950101)75:1+<353::AID-CNCR2820751317>3.0.CO;2-P
  2. Pavlidis N, Fizazi K. Carcinoma of unknown primary (CUP). Crit Rev Oncol Hematol 2009;69:271-8. https://doi.org/10.1016/j.critrevonc.2008.09.005
  3. Pavlidis N. Cancer of unknown primary: biological and clinical characteristics. Ann Oncol 2003;14 Suppl 3:iii11-8. https://doi.org/10.1093/annonc/mdg703
  4. Hess KR, Abbruzzese MC, Lenzi R, Raber MN, Abbruzzese JL. Classification and regression tree analysis of 1000 consecutive patients with unknown primary carcinoma. Clin Cancer Res 1999;5:3403-10.
  5. Briasoulis E, Pavlidis N. Cancer of unknown primary origin. Oncologist 1997;2:142-52.
  6. Morita Y, Yamagishi M, Shijubo N, Nakata H, Kurihara M, Asakawa M. Squamous cell carcinoma of unknown origin in middle mediastinum. Respiration 1992;59:344-6. https://doi.org/10.1159/000196085
  7. Yodonawa S, Mitsui K, Akaogi E, Onizuka M, Ishikawa S, Kinoshita T, et al. Squamous cell carcinoma of unknown origin affecting mediastinal lymph nodes. Nihon Kyobu Shikkan Gakkai Zasshi 1996;34:1364-8.
  8. Blanco N, Kirgan DM, Little AG. Metastatic squamous cell carcinoma of the mediastinum with unknown primary tumor. Chest 1998;114:938-40. https://doi.org/10.1378/chest.114.3.938
  9. Sakuraba M, Mae M, Oonuki T, Nitta S. Mediastinal and hilar lymph node of cancer unknown origin: 3 case reports. Nihon Kokyuki Gakkai Zasshi 1999;37:72-7.
  10. Kaneko K, Yamanda T, Hanuda M, Miyazawa M, Hanaoka T, Kondo R, et al. Metastatic squamous cell carcinoma of hilar lymph node with unknown primary site. Nihon Kokyuki Gakkai Zasshi 2000;38:39-44.
  11. Riquet M, Badoual C, le Pimpec BF, Dujon A, Danel C. Metastatic thoracic lymph node carcinoma with unknown primary site. Ann Thorac Surg 2003;75:244-9. https://doi.org/10.1016/S0003-4975(02)04119-X
  12. Tomita M, Matsuzaki Y, Shimizu T, Hara M, Ayabe T, Enomoto Y, et al. Squamous cell carcinoma of the hilar lymph node with unknown primary tumor: a case report. Ann Thorac Cardiovasc Surg 2008;14:242-5.
  13. Hainsworth JD, Greco FA. Treatment of patients with cancer of an unknown primary site. N Engl J Med 1993;329:257-63. https://doi.org/10.1056/NEJM199307223290407
  14. Fizazi K, Greco FA, Pavlidis N, Pentheroudakis G; ESMO Guidelines Working Group. Cancers of unknown primary site: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2011;22 Suppl 6:vi64-8.
  15. Hemminki K, Bevier M, Hemminki A, Sundquist J. Survival in cancer of unknown primary site: population-based analysis by site and histology. Ann Oncol 2012;23:1854-63. https://doi.org/10.1093/annonc/mdr536

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