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Efficacy of orally administered ginseng stem and leaf in chickens

인삼 지상부를 첨가한 사료 급여가 닭에서 나타내는 효과

  • Park, Soyeon (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Lee, Kwang-Yeal (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Cho, Youngjae (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Park, Bokyoung (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Kim, Kiju (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Lee, Na-Rae (Cheil Bio Co. Ltd.) ;
  • Kim, Dong-Gun (Cheil Bio Co. Ltd.) ;
  • Kim, Young-Hee (Cheil Bio Co. Ltd.) ;
  • Hahn, Tae-Wook (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University)
  • 박소연 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 이광열 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 조영재 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 박보경 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 김기주 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 이나래 (제일바이오) ;
  • 김동건 (제일바이오) ;
  • 김영희 (제일바이오) ;
  • 한태욱 (강원대학교 수의과대학 및 동물의학종합연구소)
  • Received : 2014.07.29
  • Accepted : 2014.12.12
  • Published : 2015.03.31

Abstract

Ginseng has been widely used in Korea as a natural medicine due to its saponin contents. Although the total amount of ginseng stem and leaf saponins (GSLS) is 4~5 times higher than that of saponin in the root, the root is mainly used. This is due to two reasons: nervous system-stimulant activity of GSLS and pesticide residues in GSLS. In this study, residual agricultural pesticides were removed from GSLS using two types of bacterial treatments. Two GSLS treatment groups of chickens (GSLS-1 and GSLS-2) were established. The chickens were fed 0.4% GSLS-1 or GSLS-2 mixed with crop. We then evaluated the effects of GSLS on bodyweight and several immune parameters. At the end of the experiments, chickens fed GSLS-1 and red ginseng saponin had significantly higher growth rates (16.6% and 8.0%, respectively) compared to the vaccine control group treated with Noblis Salenvac-T. The group fed GSLS-1 also had the highest IgG titer that was significantly different at the end of experiments compared to the other groups. These findings imply that GSLS-1 is a good candidate feed additive for the chicken industry.

Keywords

References

  1. Arya R, Sharma AK. Screening, isolation and characterization of Brevibacillus borstelensis for the bioremediation of carbendazim. J Environ Sci Sustainability 2014, 2, 12-14.
  2. Barenkamp SJ, Munson RS Jr, Granoff DM. Subtyping isolates of Haemophilus influenzae type b by outer-membrane protein profiles. J Infect Dis 1981, 143, 668-676. https://doi.org/10.1093/infdis/143.5.668
  3. Brekhman II. Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol 1969, 9, 419-430. https://doi.org/10.1146/annurev.pa.09.040169.002223
  4. Benishin CG. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochem Int 1992, 21, 1-5. https://doi.org/10.1016/0197-0186(92)90061-U
  5. Choi JE, Li X, Han YH, Lee KT. Changes of saponin contents of leaves, stems and flower-buds of Panax ginseng C. A. Meyer by harvesting days. Korean J Medicinal Crop Sci 2009, 17, 251-256.
  6. de Jong HK, Parry CM, van der Poll T, Wiersinga WJ. Host-pathogen interaction in invasive Salmonellosis. PLoS Pathog 2012, 8, e1002933. https://doi.org/10.1371/journal.ppat.1002933
  7. Han JH, Park SJ, Ahn CN, Wee JJ, Kim KY, Park SH. Nutritional composition, ginsenoside content and fundermental safety evaluation with leaf and stem extract of Panax ginseng. J Korean Soc Food Sci Nutr 2004, 33, 778-784. https://doi.org/10.3746/jkfn.2004.33.5.778
  8. Han JH, Sihn EH, Park SH. A study on the growth rate, nutritional effects and serum lipid contents of rats by feeding with leaf and stem extract of the ginseng radix. J East Asian Soc Diet Life 2004, 14, 407-417.
  9. Hong SH, Yoo NH, Yoo JH, Lee KH, Kim BR, Lee HJ, Kim JM, Seong NS, Pyo MK. Inhibitory effect of elastase and tyrosinase of ginsenoside F1 isolated from Panax ginseng leaves. Korean J Pharmacogn. 2013, 44, 10-15.
  10. Joo I, Kim H, Kim J, Shehzad O, Kim YS, Han Y. Effects of ginsenosides Rd and Rg1 on proliferation of B cells and antibody induction. Yakhakhoe Chi 2013, 57, 1-7.
  11. Jun HK, Kim SH. Studies of the physiological activity of Korean ginseng (part 3). The effects of ginseng saponin on the antimicrobial activity and drug-resistance of antibiotics in bacteria. Korean J Microbiol Biotechnol 1982, 10, 171-175.
  12. Kang S, Min H. Ginseng, the 'immunity boost': the effects of Panax ginseng on immune system. J Ginseng Res 2012, 36, 354-368. https://doi.org/10.5142/jgr.2012.36.4.354
  13. Kim AR, Lee MS. Screening of antimicrobial activity compounds from Korea ginseng fine root. J Life Sci 2011, 21, 1244-1250. https://doi.org/10.5352/JLS.2011.21.9.1244
  14. Kim BK, Hwang IE, Kang SS, Shin SH, Woo SC, Kim YJ, Hwang YH. Effects of dietary Panax ginseng, Dioscorea japonica and oriental medicine refuse on productivity of the Korean native chicken. J Anim Sci Technol 2002, 44, 297-304. https://doi.org/10.5187/JAST.2002.44.3.297
  15. Kim HG, Kim KY, Cha CJ. Screening for ginsengfermenting microorganisms capable of biotransforming ginsenosides. Korean J Microbiol 2007, 43, 142-146.
  16. Kim JS, Moon GS, Kim HO, Lee YS. Antioxidant properties of ginseng (P. ginseng C.A. Meyer) extracts by organic solvent fractionation. J Food Sci Nutr 2007, 12, 267-272.
  17. Kim KH, Choi I, Lee YW, Cho CK, Yoo HS, Lee SB, Choi SH, Kwon KR, Jang JH. Target genes involved in antiproliferative effect of modified ginseng extracts in lung cancer A549 cells. Acta Biochim Biophys Sin (Shanghai) 2014, 46, 441-449. https://doi.org/10.1093/abbs/gmu025
  18. Kim KH, Kim DM, Byun MW, Yun YS, Yook HS. Antioxidant activity of Panax ginseng flower-buds fermented with various microorganisms. J Korean Soc Food Sci Nutr 2013, 42, 663-669. https://doi.org/10.3746/jkfn.2013.42.5.663
  19. Kim SJ, Kim JD, KO SK. The change of ginsenoside composition in ginseng leaf and stem extract by the microwave and vinegar process. Korean J Pharmacogn 2013, 44, 149-153.
  20. Lee DH, Cho HJ, Kang HY, Rhee MH, Park HJ. Total saponin from Korean red ginseng inhibits thromboxane A2 production associated microsomal enzyme activity in platelets. J Ginseng Res 2012, 36, 40-46. https://doi.org/10.5142/jgr.2012.36.1.40
  21. Lee HM, Rhee MH. Current review on the regulation of blood pressure. Korean Ginseng Res Ind 2007, 1, 5-7.
  22. Lee HS, Lee HJ, Cho HJ, Park SS, Kim JM, Suh HJ. Cosmetic potential of enzymatic treated ginseng leaf. J Ginseng Res 2010, 34, 227-236. https://doi.org/10.5142/jgr.2010.34.3.227
  23. Lee KS, Seong BJ, Kim GH, Kim SI, Han SH, Kim HH, Baik ND. Ginsenoside, phenolic acid composition and physiological significances of fermented ginseng leaf. J Korean Soc Food Sci Nutr 2010, 39, 1194-1200. https://doi.org/10.3746/jkfn.2010.39.8.1194
  24. Lee YT, Kim KH, Ko EJ, Lee YN, Kim MC, Kwon YM, Tang Y, Cho MK, Lee YJ, Kang SM. New vaccines against influenza virus. Clin Exp Vaccine Res 2014, 3, 12-28. https://doi.org/10.7774/cevr.2014.3.1.12
  25. Lim SK, Nam HM, Moon DC, Jang GC, Jung GC; Korean Veterinary Antimicrobial Resistance Monitoring group. Antimicrobial resistance of Escherichia coli isolated from healthy animals during 2010-2012. Korean J Vet Res 2014, 54, 131-137. https://doi.org/10.14405/kjvr.2014.54.3.131
  26. Nam KY. Clinical applications and efficacy of Korean ginseng (Panax ginseng C.A.Meyer). J Ginseng Res 2002, 26, 111-131. https://doi.org/10.5142/JGR.2002.26.3.111
  27. Nawaz K, Hussain K, Choudary N, Majeed A, Ilyas U, Ghani A, Lin F, Ali K, Afghan S, Raza G, Lashari MI. Eco-friendly role of biodegradation against agricultural pesticides hazards. Afr J Microbiol Res 2011, 5, 177-183.
  28. Piao HH, Tam VTM, Na HS, Kim HJ, Ryu PY, Kim SY, Rhee JH, Choy HE, Kim SW, Hong Y. Immunological responses induced by asd and wzy/asd mutant strains of Salmonella enterica serovar Typhimurium in BALB/c mice. J Microbiol 2010, 48, 486-495. https://doi.org/10.1007/s12275-010-0023-z
  29. Ryu JH. Effects of ginseng and its constituents on the central nervous system. In: Reviews in Ginseng Research. pp. 91-103, The Korean Society of Ginseng, Seoul, 2007.
  30. Schneid ADS, Rodrigues KL, Chemello D, Tondo EC, Ayub MAZ, Aleixo JAG. Evaluation of an indirect ELISA for the detection of Salmonella in chicken meat. Braz J Microbiol 2006, 37, 350-355. https://doi.org/10.1590/S1517-83822006000300027
  31. Seol JW, Park JH, Chae JS, Kang HS, Ryu KS, Kang CS, Park SY. Effect of tissue culture medium waste after harvest of Korean wild ginseng on growth performance and diseases resistance in broiler chickens. Korean J Vet Res 2010, 50, 85-91.
  32. Song X, Bao S, Wu L, Hu S. Ginseng stem-leaf saponins (GSLS) and mineral oil act synergistically to enhance the immune responses to vaccination against foot-and-mouth disease in mice. Vaccine 2009, 27, 51-55. https://doi.org/10.1016/j.vaccine.2008.10.030
  33. Sun J, Hu S, Song X. Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice. Vaccine 2007, 25, 1114-1120. https://doi.org/10.1016/j.vaccine.2006.09.054
  34. Yoo DG, Kim MC Park MK, Song JM, Quan FS, Park KM, Cho YK, Kang SM. Protective effect of Korean red ginseng extract on the infections by H1N1 and H3N2 influenza viruses in mice. J Med Food 2012, 15, 855-862. https://doi.org/10.1089/jmf.2012.0017
  35. Zhai L, Li Y, Wang W, Wang Y, Hu S. Effect of oral administration of ginseng stem-and-leaf saponins (GSLS) on the immune responses to Newcastle disease vaccine in chickens. Vaccine 2011, 29, 5007-5014. https://doi.org/10.1016/j.vaccine.2011.04.097
  36. Zhang C, Wang Y, Wang M, Su X, Lu Y, Su F, Hu S. Rapeseed oil and ginseng saponins work synergistically to enhance Th1 and Th2 immune responses induced by the footand-mouth disease vaccine. Clin Vaccine Immunol 2014, 21, 1113-1119. https://doi.org/10.1128/CVI.00127-14

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