Genomics & Informatics

Korea Genome Organization (한국유전체학회)
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Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

  • Fu, Yu (Department of Pediatrics, University of Texas Medical Branch) ;
  • Lee, Inhan (miRcore, Ann Arbor) ;
  • Lee, Yong Sun (Department of Biochemistry and Molecular Biology, University of Texas Medical Branch) ;
  • Bao, Xiaoyong (Department of Pediatrics, University of Texas Medical Branch)
  • Received : 2015.11.21
  • Accepted : 2015.12.21
  • Published : 2015.12.31
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Abstract

tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.

Keywords

References

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