한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제32권1호
  • /
  • Pages.56-61
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  • 2015
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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Cyclophosphamide로 유발된 면역억제 마우스에서 생강의 면역 억제 효과

Immunomodulatory Effects of Zingiber officinale in Cyclophosphamide-induced Immunosuppress Mice

  • 구성욱 (경북대학교 수의과대학) ;
  • 임미경 (경운대학교 보건바이오학과) ;
  • 이근우 (경북대학교 수의과대학)
  • Koo, Sung-Wook (College of Veterinary Medicine, Kyungpook National University) ;
  • Lim, Mee-Kyung (School of Healthcare and Biotechnology, Kyungwoon University) ;
  • Lee, Keun-Woo (College of Veterinary Medicine, Kyungpook National University)
  • 심사 : 2014.12.08
  • 발행 : 2015.02.28
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초록

The object of this study was to find out the immunomodulatory effects of Ginger Aqueous extracts, as compared with that of ${\beta}$-glucan well-known an immune modulator, on the cyclophosphamide (CPA) induced immunosuppress mice. To induce immunosuppress, 150 and 110 mg/kg of CPA were dissolved in saline and injected intraperitoneally at 3 or 1 day before start of test article administration, respectively. ${\beta}$-glucan or gingers (125, 250, 500 mg/kg) were dosed, 4 times at 12-hr intervals starting 24hrs after last CPA-treatment. Distilled water was used as a vehicle and each groups were used 10 mice. As results of twice intraperitoneal CPA treatment, decreases in the body weight and gain, weight of thymus, spleen. However these CPA-induced immunosuppress changes were inhibited by treatment of three different dosages of ginger or ${\beta}$-glucan as compared with CPA control. Similar favorable inhibitory activities on weight and histopathological change of spleen and thymus induced CPA treatment were detected between ${\beta}$-glucan and ginger 250 mg/kg treated groups.

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참고문헌

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