한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제23권1호
  • /
  • Pages.1-7
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  • 2015
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
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난소절제 흰쥐에서 엉겅퀴 추출물의 골다공증 보호 효과

Osteoprotective Effect of Extract from Cirsium japonicum var. ussuriense in Ovariectomized Rats

  • 김영옥 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 김진성 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 이상원 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 조익현 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 나세원 (전북대학교 수의과대학)
  • Kim, Young Ock (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Kim, Jin Seong (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Lee, Sang Won (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Jo, Ick Hyun (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Na, Sae Won (College of Veterinary Medicine, Chonbuk National University)
  • 투고 : 2014.11.28
  • 심사 : 2014.01.07
  • 발행 : 2015.02.28
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초록

This study was carried out to investigate the effects of the Cirsium japonicum var. ussuriense (C. japonicum) extract on serum level of hormones from induced osteoporosis by ovariectomized rats. Two month-old rats were ovariectomized (OVX), remained untreated for 8 weeks, and were subsequently administered C. japonicum (200 mg/kg) every day for 8 weeks. We examined the effects of treated C. japonicum on ovariectomy-related changes in Insulin-like Growth Factors (IGF), Insulin-like Growth Factor binding protein-3 (IGBF-3), Estrogen, Calcium, and Phosporus. After 8 weeks, the serum levels of IGF-I, -II, and IGFBP-3 were higher presented as compared to the other two groups (P < 0.05), in the C. japonicum extract treatment on OVX rats. There were differences between OVX and C. japonicum extract treated OVX rats in serum levels of $Ca^{2+}$, but $Ca^{2+}$ levels for the normal group was higher than for the other two groups. The C. japonicum extract increased both serum IGFs and IGFBP-3 levels on induced osteoporotic rat by ovariectomized. Thus, these results revealed that the C. japonicum extract is a possible role for improvement of osteoporosis induced-ovariectomized rats and has a great potential as an alternative tool for the treatment of osteoporosis.

키워드

참고문헌

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피인용 문헌

  1. Flavonoids from Cirsium japonicum var. maackii pappus as inhibitors of aldose reductase and their simultaneous determination 2018, https://doi.org/10.1007/s11696-017-0259-8