Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Kidney Cancer in Lebanon: a Specific Histological Distribution?

  • Khafaja, Sarah (Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Kourie, Hampig Raphael (Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Matar, Dany (Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Sader-Ghorra, Claude (Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University) ;
  • Kattan, Joseph (Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University)
  • Published : 2015.02.04
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Kidney cancer is the third most frequent urologic cancer in Lebanon after prostate and bladder cancer, accounting for 1.5% of all diagnosed cancers. In this paper, we report the histologic characteristics and distribution of kidney cancer, never described in Lebanon or the Middle East. Materials and Methods: Pathology results of operated kidney cancer were collected during a two year period (2010-2011) from two different Lebanese hospitals (Hotel-Dieu de France University Hospital and Saint Joseph Hospital). A total of 124 reports were reviewed and analyzed according to WHO classification of 2009. Results: The 124 patients diagnosed with kidney cancer had a median age of 62.4 [18-86], 75% being men and 25% women. Some 71 % of the lesions were renal cell carcinoma (RCC), 25.8% had a urothelial histology, 1.6% were lymphomas and 1.6% were metastases to the kidney. Patients having RCC had a median age of 60.3 [18-85], 77.3% were men and 22.7% women. Of the RCCs, 59.1% were clear cell carcinoma, 22.7% papillary, 11.4% chromophobic, 3.4% rom the collecting ducts of Bellini and 3.4% were not otherwise classified. Conclusions: Histological distribution of Lebanese kidney cancer seems unusual when compared to the literature. The percentage of urothelial renal pelvis tumors is strikingly high. Moreover, clear cell carcinoma accounts for only 59.1% of RCCS in contrast to the 75% described elsewhere, while papillary carcinoma represents more than 22.7% compared to 10%.

Keywords

References

  1. Belot A, Grosclaude P, Bossard N, et al (2008). Cancer incidence and mortality in France over the period 1980-2005. Rev d'Epidemiologie et de Sante Publique, 56, 159-75. https://doi.org/10.1016/j.respe.2008.03.117
  2. Cancer of the Kidney and Renal Pelvis- SEER Stat Fact Sheets. Bethesda, MD: National Cancer Institute.
  3. Charles T, LindnerV, Matau A, et al (2010). Cancer du rein. EMC-Urol, 3, 1-30. https://doi.org/10.1016/S1762-0953(10)41416-8
  4. Chow W-H, Dong LM, Devesa SS (2010). Epidemiology and risk factors for kidney cancer. Nat Rev Urol, 7, 245-57. https://doi.org/10.1038/nrurol.2010.46
  5. Hashmi AA, Ali R, Hussain ZF et al (2014). Clinicopathologic patterns of adult renal tumors in Pakistan. Asian Pac J Cancer Prev, 15, 2303-7. https://doi.org/10.7314/APJCP.2014.15.5.2303
  6. Korkes F, Silveira TS, Castro MG et al (2006). Carcinoma of the renal pelvis and ureter. IntBraz J Urol, 32, 648-55 .
  7. Lebanese Ministry of Public Health. National Cancer Registry 2008 [Internet].Octobre 25, 2013.
  8. Lopez-Beltran A, Carrasco JC, Cheng L, et al (2009). 2009 update on the classification of renal epithelial tumors in adults. Int J Urol, 16, 432-43. https://doi.org/10.1111/j.1442-2042.2009.02302.x
  9. Lopez-Beltran A, Scarpelli M, Montironi R et al (2006).2004 WHO classification of the renal tumors of the adults. Eur Urol, 49, 798-805. https://doi.org/10.1016/j.eururo.2005.11.035
  10. Motzer RJ, Bander NH, Nanus DM (1996). Renal-cell Carcinoma. N Engl J Med, 335, 865-75. https://doi.org/10.1056/NEJM199609193351207
  11. Ozbek E, Otunctemur A, Sahin S et al (2013). Renal cell carcinoma is more aggressive in Turkish patients with the metabolic syndrome. Asian Pac J Cancer Prev, 14, 7351-4. https://doi.org/10.7314/APJCP.2013.14.12.7351
  12. Singam P, Ho C, Hong GE, et al (2010). Clinical characteristics of renal cancer in Malaysia: a ten year review. Asian Pac J Cancer Prev, 11, 503-6.
  13. Washio M, Mori M, Mikami K, et al (2013). Cigarette smoking and other risk factors for kidney cancer death in a Japanese population: Japan collaborative cohort study for evaluation of cancer risk (JACC study). Asian Pac J Cancer Prev, 14, 6523-8. https://doi.org/10.7314/APJCP.2013.14.11.6523

Cited by

  1. Epidemiology and Trends in Incidence of Kidney Cancer in Iran vol.16, pp.14, 2015, https://doi.org/10.7314/APJCP.2015.16.14.5859