Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Relation between Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-α Expression in Invasive Ductal Breast Cancer Patients and Correlations with Prognosis

  • Yan, Jian (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Liu, Xiao-Long (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Han, Lu-Zhe (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Xiao, Gang (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Li, Ning-Lei (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Deng, Yi-Nan (Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University) ;
  • Yin, Liang-Chun (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Ling, Li-Juan (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Yu, Xiao-Yuan (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Tan, Can-Liang (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Huang, Xiao-Ping (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University) ;
  • Liu, Li-Xin (Department of General Surgery, The Third Affiliated Hospital of Southern Medical University)
  • Published : 2015.02.25
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Abstract

The aim of the present study was to investigate the expression of the transcription factor Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-${\alpha}$ in the tumor tissue of patients with invasive ductal carcinoma(IDC); in addition, we examined correlations between these markers. Two hundred and sixteen IDC patients, who were not previously been treated with chemo- or radiotherapy, were included in the study. All tumors were grade I-III. Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissue sections. Follow-up data were collected for 3 months to 10 years and analyzed for tumor recurrence, survival time, and prognostic risk factors. We determined Ki-67 expression correlates with the expression of ER, PR, HER-2, EGFR, and TOP-${\alpha}$, as well as lymph node involvement, high tumor grade, lymphovascular invasion, high tumor stage, and high TNM stage in IDC. Positive Ki-67 expression was a risk factor for rapid tumor recurrence and may help tumor progression, leading to poor prognosis in IDC. Ki-67 was directly correlated with EGFR, TOP II-${\alpha}$, lymph node involvement, high tumor grade, lymphovascular invasion, high tumor stage, and high TNM stage in the hormone receptor subtypes of breast cancer. In triple negative breast cancer, Ki-67 correlated with TOP II-${\alpha}$. Expression of Ki-67 correlated with that of ER, PR, HER-2, EGFR, TOP II-${\alpha}$, and p21. In addition, the biomarker Ki-67 has a role as a prognostic factor and indicates a poor prognosis in IDC.

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